Light and electron microscopic studies of normal and heterogeneously regenerated ganglionic synapses of the dog

Taxi, J; Babmindra, V. P.

doi:10.1007/bf01245838

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…Regenerating axons of both types initially formed synapses of rather small dimensions (see also Ceccarelli et al 1971), with a scarcity of agranular synaptic vesicles 235 ELSPETH M. McLACHLAN associated with the presynaptic membrane thickening, as occurs at other newly formed synapses both during development (Bodian, 1966;Kelly & Zacks, 1968) and in tissue culture (Bunge, Bunge & Peterson, 1967;James & Tresman, 1969); at later times the synapses appeared similar to those in control ganglia, even following cross-reinnervation (see also Taxi & Babmindra, 1972). It seems unlikely therefore that the form of the terminal apparatus of a neurone is significantly altered by its environment, although the extent of membrane approximation at synapses formed in a foreign effector may not regain the dimensions of the original terminal.…”

Section: Discussionmentioning

confidence: 99%

The formation of synapses in mammalian sympathetic ganglia reinnervated with preganglionic or somatic nerves

McLachlan¹

1974

The Journal of Physiology

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SUMMARY -1. A study has been made of the formation of synapses in the superior cervical ganglion of the guinea-pig, during reinnervation either with axons of the cervical sympathetic trunk, or with somatic axons of the nerve to the sternohyoid muscle.2. No significant changes in either the geometry or electrical parameters of sympathetic motorneurones were detected following denervation for periods of 3-6 weeks, or after reinnervation with either preganglionic or somatic axons.3. The post-ganglionic action potential reappeared about 4 weeks after preganglionic trunk section (eighteen of eighteen ganglia); its amplitude increased progressively and was almost normal by more than 10 weeks after nerve section. A very small response was detected from thirteen of eighteen ganglia after periods longer than 8 weeks after cross-reinnervation with somatic axons. 4. Regenerated preganglionic or somatic nerve terminals were demonstrated around the ganglion cells using ZIO impregnation and electronmicroscopy; the structure of these terminals was unchanged following regeneration into the ganglia, although many more synapses were formed by preganglionic terminals than by somatic terminals.5. The facilitation of evoked synaptic potentials which occurs during repetitive stimulation of preganglionic axons was retained following their regeneration, whereas most synapses formed on ganglion cells by regenerating somatic axons showed facilitation of transmitter release during trains of stimuli, rather than the normal depression.6. These observations suggest that the structure and electrical properties of adult mammalian autonomic motorneurones are not under neural control, but that these neurones do show some selectivity in the type of nerve which they will permit to form synapses on them.

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Section: Discussionmentioning

confidence: 99%

The formation of synapses in mammalian sympathetic ganglia reinnervated with preganglionic or somatic nerves

McLachlan¹

1974

The Journal of Physiology

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“…Often we observed a row of postsynaptic 'Taxi bodies' of electron-opaque dots co-aligned with the synaptic junction in the postsynaptic dendrites ( Fig. 7f, right ;Taxi 1961;Taxi and Babmindra 1972) whose molecular identity remains to be determined. Collaterals of the main axon travelled within stratum oriens or at the border with alveus and the cortical white matter for a distance of 2.8 mm from the soma (40 sections of 70 μm thickness) in the caudo-lateral direction before reaching subiculum where these branched extensively.…”

Section: Input-output Synaptic Organisation Of Trilaminar Cell D37rmentioning

confidence: 93%

“…In some cases, the synaptic specialisation of trilaminar cell boutons included a row of electron opaque, discrete, spherical bodies in the postsynaptic neuronal profiles aligned with but not attached to the postsynaptic densities. Such rows of synaptic bodies were first observed in the frog ganglion (Taxi 1961), hence named Taxi bodies, and were later described also in the central nervous system mostly in association with type I presumably glutamatergic synapses (Akert et al 1967;Milhaud and Pappas 1966;Taxi and Babmindra 1972). It is very unusual to find this subsynaptic apparatus in GABAergic synapses, and their presence in trilaminar cell boutons suggests a specialised signalling mechanism with at least some of their postsynaptic neurons.…”

Section: Output Synaptic Organisation Of Trilaminar Cellsmentioning

confidence: 95%

Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum

et al. 2020

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In the hippocampal CA1 area, the GABAergic trilaminar cells have their axon distributed locally in three layers and also innervate the subiculum. Trilaminar cells have a high level of somato-dendritic muscarinic M2 acetylcholine receptor, lack somatostatin expression and their presynaptic inputs are enriched in mGluR8a. But the origin of their inputs and their behaviour-dependent activity remain to be characterised. Here we demonstrate that (1) GABAergic neurons with the molecular features of trilaminar cells are present in CA1 and CA3 in both rats and mice. (2) Trilaminar cells receive mGluR8a-enriched GABAergic inputs, e.g. from the medial septum, which are probably susceptible to hetero-synaptic modulation of neurotransmitter release by group III mGluRs. (3) An electron microscopic analysis identifies trilaminar cell output synapses with specialised postsynaptic densities and a strong bias towards interneurons as targets, including parvalbumin-expressing cells in the CA1 area. (4) Recordings in freely moving rats revealed the network state-dependent segregation of trilaminar cell activity, with reduced firing during movement, but substantial increase in activity with prolonged burst firing (> 200 Hz) during slow wave sleep. We predict that the behaviour-dependent temporal dynamics of trilaminar cell firing are regulated by their specialised inhibitory inputs. Trilaminar cells might support glutamatergic principal cells by disinhibition and mediate the binding of neuronal assemblies between the hippocampus and the subiculum via the transient inhibition of local interneurons.

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Changes in synaptic vesicles of axon terminals of the cat motor cortex after stimulation

Maloshevskii¹,

Lenkov²,

Bragina³

1976

Neurophysiology

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Light and electron microscopic studies of normal and heterogeneously regenerated ganglionic synapses of the dog

Cited by 7 publications

References 19 publications

The formation of synapses in mammalian sympathetic ganglia reinnervated with preganglionic or somatic nerves

The formation of synapses in mammalian sympathetic ganglia reinnervated with preganglionic or somatic nerves

Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum

Changes in synaptic vesicles of axon terminals of the cat motor cortex after stimulation

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