Light‐Fuelled Self‐Assembly of Cyclic Peptides into Supramolecular Tubules

Cissé, Nicolas; Kudernác, Tibor

doi:10.1002/syst.202000012

“…Recently, spiropyran (SP) and its derivatives have emerged as attractive building blocks for constructing artificial dynamic self‐assembled structures and materials [33–36] . In particular, merocyanine‐based photoacids have been used as light‐responsive regulators for generating dynamic assemblies from intrinsically non‐photoresponsive components [37–41] .…”

Section: Figurementioning

confidence: 99%

Light‐Responsive Dynamic DNA‐Origami‐Based Plasmonic Assemblies

Ryssy

¹

,

Natarajan

²

,

Wang

³

et al. 2021

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DNA nanotechnology offers a versatile toolbox for precise spatial and temporal manipulation of matter on the nanoscale. However, rendering DNA‐based systems responsive to light has remained challenging. Herein, we describe the remote manipulation of native (non‐photoresponsive) chiral plasmonic molecules (CPMs) using light. Our strategy is based on the use of a photoresponsive medium comprising a merocyanine‐based photoacid. Upon exposure to visible light, the medium decreases its pH, inducing the formation of DNA triplex links, leading to a spatial reconfiguration of the CPMs. The process can be reversed simply by turning the light off and it can be repeated for multiple cycles. The degree of the overall chirality change in an ensemble of CPMs depends on the CPM fraction undergoing reconfiguration, which, remarkably, depends on and can be tuned by the intensity of incident light. Such a dynamic, remotely controlled system could aid in further advancing DNA‐based devices and nanomaterials.

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“…[15,32] Recently, spiropyran (SP) and its derivatives have emerged as attractive building blocks for constructing artificial dynamic self-assembled structures and materials. [33][34][35][36] In particular, merocyanine-based photoacids have been used as light-responsive regulators for generating dynamic assemblies from intrinsically non-photoresponsive components. [37][38][39][40][41] Despite the numerous advantages of spiropyran and its derivatives as light-responsive molecular switches, their use in the context of DNA nanotechnology has thus far not been demonstrated.…”

mentioning

confidence: 99%

Light‐Responsive Dynamic DNA‐Origami‐Based Plasmonic Assemblies

Ryssy

¹

,

Natarajan

²

,

Wang

³

et al. 2021

View full text Add to dashboard Cite

DNA nanotechnology offers a versatile toolbox for precise spatial and temporal manipulation of matter on the nanoscale. However, rendering DNA‐based systems responsive to light has remained challenging. Herein, we describe the remote manipulation of native (non‐photoresponsive) chiral plasmonic molecules (CPMs) using light. Our strategy is based on the use of a photoresponsive medium comprising a merocyanine‐based photoacid. Upon exposure to visible light, the medium decreases its pH, inducing the formation of DNA triplex links, leading to a spatial reconfiguration of the CPMs. The process can be reversed simply by turning the light off and it can be repeated for multiple cycles. The degree of the overall chirality change in an ensemble of CPMs depends on the CPM fraction undergoing reconfiguration, which, remarkably, depends on and can be tuned by the intensity of incident light. Such a dynamic, remotely controlled system could aid in further advancing DNA‐based devices and nanomaterials.

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“… 45 − 47 While an initial attempt has been carried out on the light-fuelled self-assembly of cyclic peptides into SCPNs, more studies focusing on the transient assembly of cyclic peptides are anticipated in the next years. 48 …”

Section: Discussionmentioning

confidence: 99%

Molecular Self-Assembly and Supramolecular Chemistry of Cyclic Peptides

Song

¹

,

Cheng

²

,

Kariuki

³

et al. 2021

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This Review focuses on the establishment and development of self-assemblies governed by the supramolecular interactions between cyclic peptides. The Review first describes the type of cyclic peptides able to assemble into tubular structures to form supramolecular cyclic peptide nanotubes. A range of cyclic peptides have been identified to have such properties, including α-peptides, β-peptides, α,γ-peptides, and peptides based on δ- and ε-amino acids. The Review covers the design and functionalization of these cyclic peptides and expands to a recent advance in the design and application of these materials through their conjugation to polymer chains to generate cyclic peptide–polymer conjugates nanostructures. The Review, then, concentrates on the challenges in characterizing these systems and presents an overview of the various analytical and characterization techniques used to date. This overview concludes with a critical survey of the various applications of the nanomaterials obtained from supramolecular cyclic peptide nanotubes, with a focus on biological and medical applications, ranging from ion channels and membrane insertion to antibacterial materials, anticancer drug delivery, gene delivery, and antiviral applications.

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Light‐Fuelled Self‐Assembly of Cyclic Peptides into Supramolecular Tubules

Cited by 21 publications

References 23 publications

Light‐Responsive Dynamic DNA‐Origami‐Based Plasmonic Assemblies

Light‐Responsive Dynamic DNA‐Origami‐Based Plasmonic Assemblies

Light‐Responsive Dynamic DNA‐Origami‐Based Plasmonic Assemblies

Molecular Self-Assembly and Supramolecular Chemistry of Cyclic Peptides

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