2019
DOI: 10.1016/j.yjmcc.2019.06.004
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Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity

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Cited by 9 publications
(16 citation statements)
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“…For these reasons we support the concept of BAV as a syndrome 11,12,23 , with a complex pathophysiology, characterized by the deregulation of TLR4 and Notch-1 pathways, that are known to be crucial for the physiological homeostasis and function of aortic valve endothelial (AVEC) and interstitial (AVIC) cells, as well as the aorta wall cells. Consequently, we propose that the altered function and expression of these two pathways, observed in BAV disease, result in a reduced functionality of AVEC, AVIC and aortic wall cells, with an increased susceptibility to senescence and chronic inflammation finally leading to a functional impairment 8,9,16,3335 .…”
Section: Discussionsupporting
confidence: 72%
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“…For these reasons we support the concept of BAV as a syndrome 11,12,23 , with a complex pathophysiology, characterized by the deregulation of TLR4 and Notch-1 pathways, that are known to be crucial for the physiological homeostasis and function of aortic valve endothelial (AVEC) and interstitial (AVIC) cells, as well as the aorta wall cells. Consequently, we propose that the altered function and expression of these two pathways, observed in BAV disease, result in a reduced functionality of AVEC, AVIC and aortic wall cells, with an increased susceptibility to senescence and chronic inflammation finally leading to a functional impairment 8,9,16,3335 .…”
Section: Discussionsupporting
confidence: 72%
“…In this context, investigations that clarify the effects of environmental triggers, such as diet, allergens, air pollution, drugs in the pathophysiology of BAV and AAA complication through activation of TLR-4 pathway, including the intriguing link between the intestinal microbiota and BAV mediated by the TLR4-pathway 43 , might also be helpful. Since everyone is the result of the sophisticated interplay between environmental factors and its genome, trascriptome, proteome, metabolome, microbiome, epigenome, exposome, we here suggest that it is necessary to perform a more complex combination of investigations based on these aspects for obtaining interesting data in the study of BAV and AAA complication 1,11,12 .…”
Section: Discussionmentioning
confidence: 98%
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