Light-responsive nanoparticles based on new polycarbonate polymers as innovative drug delivery systems for photosensitizers in PDT

Anderski, Juliane; Mahlert, Laura; Sun, Jingjiang; Birnbaum, Wolfgang; Mulac, Dennis; Schreiber, Sebastian J.; Herrmann, Fabian; Kuckling, Dirk; Langer, Klaus

doi:10.1016/j.ijpharm.2018.12.040

Cited by 47 publications

(30 citation statements)

References 23 publications

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“…In a subsequent work by Langer and co‐workers, the PEGylated light‐responsive nanoparticles were biocompatible and employed as drug carrier for the photosensitizer mTHPC in photodynamic therapy ( Figure a). After illumination with 365 nm UV light for 5 min (174 J cm −2 ), in vitro drug release studies showed that nanoparticles containing 50 wt% LrPC (mTHPC‐(LrPC50%‐PEG)‐PLGA‐NP) underwent a burst release of 43.2 ± 8.2% mTHPC, which is two times faster than the nonilluminated nanoparticles (15.0 ± 2.2%) (Figure b).…”

Section: Uv/vis Light Controlled Drug Delivery Systemsmentioning

confidence: 99%

Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives

Zhao

Wang

et al. 2019

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Engineering of smart photoactivated nanomaterials for targeted drug delivery systems (DDS) has recently attracted considerable research interest as light enables precise and accurate controlled release of drug molecules in specific diseased cells and/or tissues in a highly spatial and temporal manner. In general, the development of appropriate light‐triggered DDS relies on processes of photolysis, photoisomerization, photo‐cross‐linking/un‐cross‐linking, and photoreduction, which are normally sensitive to ultraviolet (UV) or visible (Vis) light irradiation. Considering the issues of poor tissue penetration and high phototoxicity of these high‐energy photons of UV/Vis light, recently nanocarriers have been developed based on light‐response to low‐energy photon irradiation, in particular for the light wavelengths located in the near infrared (NIR) range. NIR light‐triggered drug release systems are normally achieved by using two‐photon absorption and photon upconversion processes. Herein, recent advances of light‐responsive nanoplatforms for controlled drug release are reviewed, covering the mechanism of light responsive small molecules and polymers, UV and Vis light responsive nanocarriers, and NIR light responsive nanocarriers. NIR‐light triggered drug delivery by two‐photon excitation and upconversion luminescence strategies is also included. In addition, the challenges and future perspectives for the development of light triggered DDS are highlighted.

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Section: Uv/vis Light Controlled Drug Delivery Systemsmentioning

confidence: 99%

Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives

Zhao

Wang

et al. 2019

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234

137

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“…In an original approach, light-responsive self-immolative polymers [70,71] (Figure 5a) based on a polycarbonate backbone have been proposed. Here a photolabile o-nitrobenzyl group can be removed through a redox photoisomerization process, leading to the release of a functional amine group inducing intramolecular cyclization.…”

Section: Physical Solubilization Of the Photosensitizermentioning

confidence: 99%

Rational design of block copolymer self-assemblies in photodynamic therapy

Demazeau¹,

Gibot²,

Mingotaud³

et al. 2020

Beilstein J. Nanotechnol.

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Photodynamic therapy is a technique already used in ophthalmology or oncology. It is based on the local production of reactive oxygen species through an energy transfer from an excited photosensitizer to oxygen present in the biological tissue. This review first presents an update, mainly covering the last five years, regarding the block copolymers used as nanovectors for the delivery of the photosensitizer. In particular, we describe the chemical nature and structure of the block copolymers showing a very large range of existing systems, spanning from natural polymers such as proteins or polysaccharides to synthetic ones such as polyesters or polyacrylates. A second part focuses on important parameters for their design and the improvement of their efficiency. Finally, particular attention has been paid to the question of nanocarrier internalization and interaction with membranes (both biomimetic and cellular), and the importance of intracellular targeting has been addressed.

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“…Such a goal can be achieved developing self-regulated drug delivery systems, most of them being based on intelligent or stimulisensitive polymers [4][5][6]. These polymers undergo a phase transition when minor changes of the environmental parameters including pH [7], temperature [8], ionic strength [9], light [10], and electric or magnetic field [11,12] occur. Among these, temperature-sensitive polymers are the most used materials for biomedical applications because they exploit the change of the human body temperature to modify their properties [13,14].…”

Section: Introductionmentioning

confidence: 99%

Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism

Fundueanu¹,

Constantin²,

Bucatariu³

et al. 2020

Express Polym. Lett.

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Poly(N-isopropylacrylamide-coN -vinylpyrrolidone) (poly(NIPAAm-co-NVP)) with a co-monomer molar ratio in copolymer of 91.5/8.5 (NIPAAm/NVP) was synthesized as an interesting thermosensitive material possessing a sharp phase transition at 36°C under simulated physiological conditions. The effect of the co-monomer molar ratio as well as of the ionic strength and nature of ions on the lower critical solution temperature (LCST) was investigated. Cross-linked poly(NIPAAm-co-NVP) thermoresponsive microspheres were synthesized by the suspension polymerization technique respecting the same NIPAAm/NVP molar ratio as for linear polymer. The microspheres were loaded with the model drug diclofenac (DF) by the solvent evaporation method; differential scanning calorimetry (DSC) demonstrates a dispersion of drug crystals within the polymeric matrix. The DF release rate is deeply influenced by the drug loading degree. Only microspheres with low DF loading are able to release the bioactive compound through a pulsatile mechanism.

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Light-responsive nanoparticles based on new polycarbonate polymers as innovative drug delivery systems for photosensitizers in PDT

Cited by 47 publications

References 23 publications

Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives

Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives

Rational design of block copolymer self-assemblies in photodynamic therapy

Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism

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