Light therapy by blue LED improves wound healing in an excision model in rats

Adamskaya, Natalia; Dungel, Peter; Mittermayr, Rainer; Hartinger, Joachim; Feichtinger, Georg A.; Wassermann, Klemens; Redl, Heinz; Griensven, Martijn van

doi:10.1016/j.injury.2010.03.023

Cited by 143 publications

(123 citation statements)

References 34 publications

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“…Since laser wavelength can affect depth of tissue penetrance, perhaps the combined use of both short and long wavelengths could provide a synergistic effect on mucositis outcomes. -The newly available blue LED has potential for the management of OM, and research is warranted based on the known effects of this light therapy in wound healing [43].…”

Section: Discussionmentioning

confidence: 99%

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Migliorati

Hewson

Lalla

et al. 2012

Support Care Cancer

215

105

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Background The aim of this study was to review the available literature and define clinical practice guidelines for the use of laser and other light therapies for the prevention and treatment of oral mucositis. the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible. Results A new recommendation was made for low-level laser (wavelength at 650 nm, power of 40 mW, and each square centimeter treated with the required time to a tissue energy dose of 2 J/cm 2 (2 s/point)) for the prevention of oral mucositis in adult patients receiving hematopoietic stem cell transplantation conditioned with high-dose chemotherapy, with or without total body irradiation. A new suggestion was made for low-level laser (wavelength around 632.8 nm) for the prevention of oral mucositis in patients undergoing radiotherapy, without concomitant chemotherapy, for head and neck cancer. No guideline was possible in other populations and for other light sources due to insufficient evidence. Conclusions The increasing evidence in favor of low-level laser therapy allowed for the development of two new guidelines supporting this modality in the populations listed above. Evidence for other populations was also generally encouraging over a range of wavelengths and intensities. However, additional well-designed research is needed to evaluate the efficacy of laser and other light therapies in various cancer treatment settings. Methods

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Section: Discussionmentioning

confidence: 99%

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Migliorati

Hewson

Lalla

et al. 2012

Support Care Cancer

215

105

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“…Badacze z Austrii stwierdzili, że fale o długości 470 nm ze źródła LED korzystnie wpływają na proces gojenia ran, m.in. poprzez poprawę ukrwienia związaną ze zwiększonym uwalnianiem tlenku azotu z kompleksów nitrozylu z hemoglobiną [24]. Duże nasilenie procesów angiogenezy, poprawę perfuzji tkankowej i przyspieszenie gojenia zaobserwowano również u gryzoni w modelu ran niedokrwiennych, gdzie zastosowano naświetla-nie diodami LED niebieskimi o długości fali 470 nm (50 mW/cm 2 ) oraz diodami LED czerwonymi o dłu-gości 629 nm (50 mW/cm 2 ) przez 10 minut w ciągu 5 kolejnych dni [25].…”

Section: Diody Elektroluminescencyjne Ledunclassified

Light-emitting diodes in dermatology: stimulation of wound healing

Fryc¹

2016

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StreSzczenieTerapia światłem o małej mocy, określana skrótem LLLT (ang. low-level light therapy), niekiedy nazywana również fototerapią, jest skuteczną strategią stosowaną w gojeniu ran oraz w celu redukcji dolegliwości bólowych, zapalenia i obrzęku tkanek. W fototerapii coraz powszechniej używa się nowego rodzaju źródła światła, którym jest dioda elektroluminescencyjna (LED). Efekty biologiczne związane z działaniem promieniowania emitowanego przez diody LED są w głównej mierze uzależnione od długości fali i dawki. W pracy przedstawiono przegląd wyników badań dotyczących stymulacji gojenia ran z użyciem terapii światłem LED o małej mocy oraz podkreślono wagę doboru optymalnych parametrów LLLT do tego celu. Omówiono także mechanizmy działania LLLT na poziomie komórkowym i tkankowym. AbStrActLow-level light therapy (LLLT), which is sometimes included in phototherapy, is an effective therapeutic strategy to improve wound healing and reduce pain, inflammation and swelling. Nowadays, new sources of light, such as light-emitting diodes (LEDs) with a broad range of wavelengths, are widely available. The biological effects promoted by LEDs are dependent on irradiation parameters, mainly wavelength and dose. This review article focuses on recent clinical trials using light-emitting diode low-level light therapy (LED-LLLT) for enhancing wound healing. In this article, we also cover the mechanisms of action of LLLT on cells and tissues and highlight the importance of defining optimum LLLT parameters for stimulation of wound healing.

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“…Besides, LED is also used in dermatology [9]. In animal experiments, blue LED light can accelerate wound healing of mice [10]. Wu et al proposed stimulating Neiguan point (PC6) with low level laser was used to adjust the ANS of the night shift workers [11].…”

Section: Background/ Objectives and Goalsmentioning

confidence: 99%

The Embedded System Integrated ECG Monitoring and Low Energy Led Light Stimulation

Shan¹,

Wu²,

Chen³

et al. 2016

ujph

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Background: Nowadays people usually have higher work pressure and faster life rhythm. In the long-term stress environment, easily lead to autonomic nervous system (ANS) disorders and lead to physiological or psychological problems. To resolve the problem, we propose an embedded system which integrates ANS monitoring and low energy light stimulation. When the ANS was detected abnormal, a recommended low energy infrared light was activated to stimulate the subject to balance ANS. Materials and Methods: The experiment instruments included electrocardiogram (ECG) module, LED array and the embedded system. ECG module received ECG signal, and then transferred analog signal to digital data. The microprocessor calculated time-domain and frequency-domain data of heart rate variability (HRV), and analyzed the time-domain data, and power spectral density data. The autonomic nervous system (ANS) of the user can be monitored by this device we developed. When the calculated values are out of the criteria, the system will alert the user to turn on infrared light to stimulate and balance ANS. LED wavelength is 850 nm, the default output power is 10 mW, and the default repetition rate is 10 Hz. Result: Wu et al. proposed that using low level laser to stimulate on Neiguan point (PC6) was used to adjust the ANS of the night shift workers. And in other studies, Laser array and LED array were used to stimulate the palm of the subjects with open eyes in different clinical trial, the alpha powers were both increased significantly. So the combination of ANS monitoring and light therapy was useful and feasible. Besides ECG monitoring, LED irradiation and HRV calculation, the data of the embedded system can be transmitted by UART to the remote PC for storage, display and analysis. Furthermore, the embedded system can receive the setting value from PC. For example, adjusting the irradiated dosage, LED operation rate and duty cycle to find out the influence factor of the ANS. Conclusion: an embedded system with ECG monitoring and LED infrared stimulation was realized, it combined physiological state monitoring and light stimulation, it make the ANS feedback and real time adjustment possible.

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Light therapy by blue LED improves wound healing in an excision model in rats

Cited by 143 publications

References 34 publications

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Light-emitting diodes in dermatology: stimulation of wound healing

The Embedded System Integrated ECG Monitoring and Low Energy Led Light Stimulation

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