2012
DOI: 10.1002/adma.201200650
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Light‐Triggered Theranostics Based on Photosensitizer‐Conjugated Carbon Dots for Simultaneous Enhanced‐Fluorescence Imaging and Photodynamic Therapy

Abstract: Novel theranostics based on photosensitizer‐conjugated carbon dots is reported. The prepared C‐dots–Ce6 has good stability and high water dispersibility and solubility, non‐cytotoxicity, good biocompatibility, enhanced photosensitizer fluorescence detection and remarkable photodynamic efficacy upon irradiation. The C‐dots–Ce6 conjugate is a good candidate with excellent imaging and tumor‐homing ability for NIR fluorescence imaging monitored PDT treatment.

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Cited by 667 publications
(417 citation statements)
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“…Luminescent carbon dots (CDs) have recently emerged as light‐emitting nanomaterials with a high PLQY, high photostability, excellent biocompatibility, and low toxicity, which can be easily produced by both top‐down and bottom‐up chemical synthesis methods with low cost;5 all this endow them distinct benefits for bioimaging6 and lighting applications 7. Compared with rare‐earth phosphors, CDs have much shorter luminescence lifetimes of just a few nanoseconds, which make them potential candidate as color converter for high modulation bandwidth in VLC.…”
mentioning
confidence: 99%
“…Luminescent carbon dots (CDs) have recently emerged as light‐emitting nanomaterials with a high PLQY, high photostability, excellent biocompatibility, and low toxicity, which can be easily produced by both top‐down and bottom‐up chemical synthesis methods with low cost;5 all this endow them distinct benefits for bioimaging6 and lighting applications 7. Compared with rare‐earth phosphors, CDs have much shorter luminescence lifetimes of just a few nanoseconds, which make them potential candidate as color converter for high modulation bandwidth in VLC.…”
mentioning
confidence: 99%
“…In our previous work, with the aim of finding early gastric cancer, we screen out some new biomarkers associated with early gastric cancer and develop novel ultrasensitive detection methods [8][9]. We also designed and fabricated some multifunctional nanoprobes for targeted imaging and simultaneous therapy of subcutaneous and in situ gastric cancer tissues with 5 mm in diameter [10][11][12][13][14][15][16][17][18][19][20][21][22]. Among those multifunctional nanoprobes, RGDconjugated gold nanorods could target tumor tissues and kill tumor cells via photothermal therapy [14], exhibiting potential clinical application prospects.…”
Section: Introductionmentioning
confidence: 99%
“…In addition to the architecture itself, the colloids whose solute particle size ranges from 10 9 m to 10 6 m obtained from the carbon nanomaterial demonstrate excellent functions as well 5 . C-Dots mainly act as nonmetal quantum dots, and demonstrate promising potential in the development of bioimaging 6 and other clinic applications 7 owing to its excellent biocompatibility 8 . Fullerene is a sphere shaped carbon nanomaterial.…”
Section: Introductionmentioning
confidence: 99%