Lighting up hydrogen peroxide in living cells by a novel quinoxalinamine based fluorescent probe

Recent Progress in Organic Small-Molecule Fluorescent Probe Detection of Hydrogen Peroxide

“…Zhang et al designed an off–on fluorescent probe (example 2) based on ICT for sensing H 2 O 2 . 4 A novel fused quinoxaline was used as the fluorescent group, and the boronate moiety was the reaction site. As a typical ‘‘push–pull” electron-conjugated structure, probe 2 possessed good fluorescence properties such as higher fluorescence quantum yields.…”

“…Zhang et al designed an off–on fluorescent probe (example 2) based on ICT for sensing H 2 O 2 . A novel fused quinoxaline was used as the fluorescent group, and the boronate moiety was the reaction site.…”

Mechanochemical synthesis of an AIE-TICT-ESIPT active orange-emissive chemodosimeter for selective detection of hydrogen peroxide in aqueous media and living cells, and solid-phase quantitation using a smartphone

“…As a result, a wide range of small-molecule fluorophores have been utilized for the detection of peroxides. [22][23][24][25][26][27][28][29][30][31][32][33][34] However, several of them are not sensitive or selective enough towards hydrogen peroxide, and they often require the use of toxic reagents or organic solvents for their multi-step synthesis.…”

Regulating the activity of boronate moiety to construct fluorescent probes for the detection of ONOO−in vitroandin vivo

“…, ONOO − , H 2 O 2 )-recognizing portion, with some developed fluorescent probes listed in Schemes S1–S3 (ESI†), the substituent effect has not been studied in the reported publications. 32–67 Resorufin dye possesses several advantages, including bright red emission, excellent stability, high fluorescence quantum yield, and good photostability. 68,69 Several boronate-containing resorufin probes have been reported to be able to detect tyrosinase, benzoyl peroxide (BPO), or hydrogen peroxide (H 2 O 2 ); however, the response rates were slow (10 min to 10 h, Table S1, ESI†).…”