Lignans and triterpenoids from Vitex negundo var. heterophylla and their biological evaluation

Hu, Ping; Li, Dahong; Hu, Xu; Li, Sheng-Ge; Sai, Chunmei; Sun, Xiaocong; Su, Tong; Bai, Jiao; Wang, Zihou; Li, Zhan‐Lin; Hua, Hui‐Ming

doi:10.1016/j.fitote.2016.04.020

Cited by 24 publications

(14 citation statements)

References 18 publications

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“…Negundonorin A ( 192 ) isolated from V. negundo seeds showed strong cytotoxicity against breast cancer (ZR‐75‐30) cells with IC 50 value of 0.56 ± 0.19 μg/ml, while negunfurol ( 430 ) isolated from the same plant exhibited potent cytotoxicity against HL‐60 cells with IC 50 of 0.94 ± 0.26 μg/ml (Zheng, Pu, et al, 2012). The compound (6‐hydroxy‐4‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐hydroxymethyl‐7‐methoxy‐3,4‐dihydro‐2‐naphthaldehyde) (371) was isolated from V. negundo seeds and exhibited cytotoxic activity against HepG2 comparable to positive control (Hu et al, 2016). A clerodane‐type diterpene named acuminolide ( 140 ) isolated from V. cofassus Reinw.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

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Traditional uses, phytochemistry, and pharmacology of genus Vitex (Lamiaceae)

Das

Salgueiro

Choudhury³

et al. 2021

Phytotherapy Research

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Vitex, the genus of the family Lamiaceae, comprises of about 230 species mostly distributed in the warm regions of Europe and temperate regions of Asia. Several Vitex species have been used as folk medicine in different countries for the treatment of various kinds of diseases and ailments. The main aim of this review is to collect and analyze the scientific information available about the Vitex species regarding their chemical constituents and pharmacological activities. The phytochemical investigation of various Vitex species has resulted in the isolation of about 556 chemical constituents belong to various chemical category viz. iridoids, diterpenoids, triterpenoids, flavonoids, lignans, sesquiterpenoids, monoterpenoids, ecdysteroids, and others. The crude extracts of different Vitex species as well as pure phytochemicals exhibited a wide spectrum of in-vitro and in-vivo pharmacological activities. In the present review, the scientific literature data on the ethnopharmacological, phytochemical, and pharmacological investigations on the genus Vitex are summarized. More attention should be given in future research to evaluate the pharmacological potential with detailed mechanism of actions for the pure compounds, extracts of plants from this genus.Moreover, their clinical study is needed to justify their use in modern medicine and to further exploring this genus for new drug discovery.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

“…V. negundo seeds and exhibited cytotoxic activity against HepG2 comparable to positive control (Hu et al, 2016). A clerodane-type diterpene named acuminolide (140) isolated from V. cofassus Reinw.…”

Section: Anticancer Activitymentioning

confidence: 99%

Traditional uses, phytochemistry, and pharmacology of genus Vitex (Lamiaceae)

Das

Salgueiro

Choudhury³

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

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“…Lignans are a group of polyphenolic compounds present in plants. It has been shown that lignans have anti-cancer, antiinflammation, anti-oxidation and neuroprotection activities Adfa [116]; Hu [117]; Li [118]; Teponno [119]. Ultrasound-assisted extraction has been successfully used in the extraction of lignans such as honokiol and magnolol from Magnoliae officinalis Zhang [120].…”

Section: Extraction Of Lignansmentioning

confidence: 99%

Applications and Prospects of Ultrasound-Assisted Extraction in Chinese Herbal Medicine

Zhou

2019

OAJBS

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“…heterophylla (Huludao, Liaoning, China). Vitexnegheteroins E ( 387 ) and H ( 388 ) displayed activities against LPS-induced NO production with IC 50 values of 17.27 and 17.23 μM (positive control SMT, 1.83 μM) (Hu et al, 2016b ). The stems of Nauclea officinalis (Hainan, China) contained two novel indole alkaloids, namely nauclealises A and B. Nauclealise A ( 389 ) showed activity against the LPS-induced NO production in RAW 264.7 macrophages with an IC 50 value of 0.82 μM, more active than aminoguanidine (1.80 μM) (Chen et al, 2016a ).…”

Section: Terrestrial Plantsmentioning

confidence: 99%