Lignin-derived lignophenols attenuate oxidative and inflammatory damage to the kidney in streptozotocin-induced diabetic rats

Abstract

This study investigated the effects of lignin-derived lignophenols (LPs) on the oxidative stress and infiltration of macrophages in the kidney of streptozotocin (STZ)-induced diabetic rats. The diabetic rats were divided into four groups with 0%, 0.11%, 0.33% and 1.0% LP diets. The vehicle-injected controls were given a commercial diet. At 5 weeks, superoxide (O(2)(-)) production, macrophage kinetics, the degree of fibrosis in glomeruli and mRNA expression for monocyte chemoattractant protein-1 (MCP-1) were examined. The NADPH-stimulated O(2)(-) levels in the kidney of the diabetic rats treated with 1.0% LP were significantly lower than those in untreated diabetic rats. The number of macrophages, levels of MCP-1 mRNA expression and degree of glomerular fibrosis increased in untreated LP and these levels were significantly lower in 1.0%LP-treated rats. The results suggested that LPs suppress the excess oxidative stress, the infiltration and activation of macrophages and the glomerular expansion in STZ-induced diabetic kidneys.

Lignin-Derived Biomaterials for Drug Release and Tissue Engineering

“…The decrease of oxidative and inflammatory damage to the kidney in streptozotocin-induced diabetic rats due to lignin-derived lignophenols was reported by Sato et al [51]. Similar to these results, low molecular weight lignins were tested regarding their potential as anti-emphysema agents in vitro [52].…”

Lignin-Derived Biomaterials for Drug Release and Tissue Engineering

“…Lignin nanoparticles incorporated in polylactic acid (PLA) revealed an innovative capacity to inhibit the bacterial growth along the time [ 49 ]. The decrease of oxidative and inflammatory damage to the kidney in streptozotocin-induced diabetic rats due to lignin-derived lignophenols was reported by Sato et al [ 51 ]. Similar to these results, low molecular weight lignins were tested regarding their potential as anti-emphysema agents in vitro [ 52 ].…”

A Review: Depolymerization of Lignin to Generate High-Value Bio-Products: Opportunities, Challenges, and Prospects

“…In terms of diabetes control, it's reported that LPs from beech tree (Fagus crenata Blume) played an active role in attenuating oxidative stress and inflammatory damage, activating macrophages as well as promoting glomerular expansion in the kidneys of streptozotocin (STZ)-induced diabetic rats (Sato et al, 2009). LPs-containing diets were proved to be very helpful for lowering plasma triglyceride levels in rats fed a high-fat diet by potentially suppressing the expression of sterol regulatory element-binding protein (SREBP) and acetyl-CoA carboxylase (ACC) (Sato et al, 2012).…”