Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion

Zhanbo, Feng; Lu, Yapeng; Wu, Xiaomei; Zhao, Peng; Li, Jiejia; Peng, Bin; Qian, Zhong Ming; Zhu, Li

doi:10.1016/j.jep.2012.09.014

Cited by 74 publications

(41 citation statements)

References 31 publications

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“…2A, the escape latency to find the hidden platform in the sham group decreased gradually, while the 2VO rats spent more time in the training trials (P<0.01, compared with the model group). These observations are consistent with the results of behavioral tests reported elsewhere (16). The rats in the BHD-M, BHD-H dosage of BHD and positive control (GB) groups demonstrated improved cognitive abilities compared with the 2VO rats from days 7 and 14 of the tests (P<0.05 or P<0.01, compared with the model group), whereas low-dose BHD did not induce any significant improvements.…”

Section: Bhd Improves Spatial Learning and Memory Of Rats With 2vo Insupporting

confidence: 91%

Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

et al. 2014

Molecular Medicine Reports

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Abstract. Cerebral hypoperfusion is a common feature of vascular dementia and has recently been recognized to contribute to the progression of cognitive decline. The present study aimed to investigate the effects of Bushen Huoxue decoction (BHD), a two-herb Chinese Medicine, on cognitive impairment in a rat model of cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries (2VO). The results demonstrated that BHD significantly attenuated learning and spatial memory deficits in the Morris water maze test in a dose-dependent manner. Transmission electron microscopy observation revealed that the reduction of synapse density in hippocampal CA1 and cortex parietal isolated from rats with 2VO was partially restored by BHD treatment. In addition, the expression levels of a number of antioxidants, including superoxide dismutase, catalase (CAT), glutathine and glutathione peroxidase-1 (GPx-1) increased, whereas malondialdehyde decreased in the hippocampi of rats with 2VO following BHD treatment. Polymerase chain reaction and western blot analysis further confirmed that the GPx-1 and CAT expression increased in the BHD treatment group. In conclusion the results suggested that BHD has therapeutic potential to treat vascular dementia, which may be associated with synapse density and anti-oxidant activities in the hippocampus.

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Section: Bhd Improves Spatial Learning and Memory Of Rats With 2vo Insupporting

confidence: 91%

Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

et al. 2014

Molecular Medicine Reports

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“…Roots of this plant yield essential oils which bring high prices due to multiple utility in modern medicine including aromatherapy [13]. The species is reported to have a great pharmaceutical importance and shown to have therapeutical and anti-inflammatory effects due to their active components like butylidene phthalide and ligustilide [14][15][16][17][18]. Previous work has done on essential oil of A. glauca from Himalayan regions (Kashmir, Himachal Pradesh and Kumaun Himalaya), which has shown great qualitative and quantitative variations in their oil compositions [19][20][21][22][23].…”

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confidence: 99%

Essential Oil Constituents of Angelica glauca Edgew. Roots: An Endangered Species from Uttarakhand Himalaya (India)

Purohit

Andola

Haider

et al. 2015

Natl. Acad. Sci. Lett.

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The roots of Angelica glauca Edgew., a high value critically endangered plant, were collected from two alpine Himalayan locations of Uttarakhand (India). The essential oils were obtained by hydro-distillation, analyzed by gas chromatography (GC) and gas chromatographymass spectrometry (GC-MS) in order to determine the variation of concentration in their constituents. A total of 26 compounds were identified in both the oils, representing 97.7-98.2 % of total oil compositions. The major components of A. glauca oils were characterised as (Z)-ligustilide (40.6-53.0 %), (Z)-butylidene phthalide (20.7-32.8 %), (E)-butylidene phthalide (2.5-5.9 %) and (E)-ligustilide (2.1-2.3 %). Due to the higher relative area quantum of monomeric lactones (phthalides and ligustilides) in A. glauca populations (69.3-90.6 %) growing in Uttarakhand, there is a need to develop propagation protocol for mass multiplication and in situ and ex situ conservation.

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“…As found in our previous studies, ferulic acid (3), senkyunolide I (4), senkyunolide H (5), senkyunolide A (6), coniferyl ferulate (7), Z-ligustilide (8), sedanolide (9), 3-butylidenephthalide (10), riligustilide (11) and levistolide A (12) were the main components in Chuanxiong [1,2] and their contributions to pharmacological activities of Chuanxiong have been verified by our own and other research teams' studies [3][4][5][6][7][8][9][10][11][12][13][14]. Moreover, our pharmacokinetic study of Chuanxiong extract also revealed these compounds, especially 6 and 8, as the main in vivo available ingredients of Chuanxiong [15,16].…”

Section: Introductionmentioning

confidence: 74%

Extraction of the Main Ingredients from Chuanxiong by CO<sub>2</sub> Supercritical Fluid Extraction

Yan¹,

Li²,

Lin³

2012

AJAC

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As one of the most frequently used medicinal herbs in China, Chuanxiong Rhizoma (Chuanxiong) is notable for its beneficial effects in alleviation of cardio-and cerebro-vascular disorders. Results from previous phytochemical, pharmacological and pharmacokinetic studies supported the contributions of 10 main components, namely ferulic acid (3), senkyunolide I (4), senkyunolide H (5), senkyunolide A (6), coniferylferulate (7), Z-ligustilide (8), sedanolide (9), 3-butylidenephthalide (10), riligustilide (11) and levistolide A (12), for therapeutic outcomes of the herb. To prepare a Chuanxiong extract, which is selectively enriched with these main components, the supercritical fluid extraction (SCFE) technique using CO 2 was chosen in the present study due to its superiority in extraction of lipophilic components, especially thermo-labile components from natural products. Eight Chuanxiong samples were extracted under different SCFE conditions. Contents of 3-12 in SCFE extracts and remained in herbal residues were determined using HPLC-UV and compared with those in 95% ethanol extracts of the respective herbal samples. The results showed that contents of 3-12 were generally enriched by SCFE with higher recoveries achieved for lipophilic constituents, including the three most abundant constituents 6, 7 and 8. Moreover, extraction yield of the less lipophilic 3, 4 and 5 was improved by adding ethanol as entrainer. Higher flow rate of CO 2 (10 -13 L/h vs 9 -12 L/h) enhanced the overall extraction, while lower temperature (32˚C vs 40˚C) reduced degradation of thermo-labile compounds, in particular 7, 8 and 10. Our established SCFE condition yielded high extraction recoveries for both total (75.6%) and three major chemical ingredients (6: 83.5%, 7: 77%, 8: 78.3%) from Chuanxiong with an adequate overall reproducibility, demonstrating a successful application of SCFE in selective enrichment of certain ingredients and efficient extraction of thermo-labile components from medicinal herbs using specifically designed SCFE conditions.

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Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion

Cited by 74 publications

References 31 publications

Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

Essential Oil Constituents of Angelica glauca Edgew. Roots: An Endangered Species from Uttarakhand Himalaya (India)

Extraction of the Main Ingredients from Chuanxiong by CO<sub>2</sub> Supercritical Fluid Extraction

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Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion

Cited by 74 publications

References 31 publications

Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

Essential Oil Constituents of Angelica glauca Edgew. Roots: An Endangered Species from Uttarakhand Himalaya (India)

Extraction of the Main Ingredients from Chuanxiong by CO&lt;sub&gt;2&lt;/sub&gt; Supercritical Fluid Extraction

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Extraction of the Main Ingredients from Chuanxiong by CO<sub>2</sub> Supercritical Fluid Extraction