Lily bulbs’ polyphenols extract ameliorates oxidative stress and lipid accumulation in vitro and in vivo

Abstract

BACKGROUND Polyphenols have the potential to reduce the risk of many metabolic disorders. Lily bulbs are rich in polyphenols; however, their effects on lipid metabolism remain unclear. This study aimed to explore the effects of lily bulbs’ polyphenols (LBPs) on oxidative stress and lipid metabolism. RESULTS A total of 14 polyphenolic compounds in LBPs were identified by high‐performance liquid chromatography equipped with diode‐array detection mass spectrometry. Total phenolic compound in LBPs was 53.76 ± 1.12 g kg−1 dry weight. In cellular experiments, LBPs attenuated the disruption of mitochondrial membrane potential, impeded reactive oxygen species production, alleviated oxidative stress, and reduced lipid accumulation in oleic acid induced HepG2 cells. In in vivo studies, LBPs significantly inhibited body weight gain, reduced lipid levels in serum and liver, and improved oxidative damage in a dose‐dependent manner in mice fed a high‐fat diet. Moreover, LBPs ameliorated hepatic steatosis and suppressed the expression of hepatic‐lipogenesis‐related genes (SREBP‐1c, FAS, ACC1, and SCD‐1) and promoted lipolysis genes (SRB1 and HL) and lipid oxidation genes (PPARα and CPT‐1) in mice fed a high‐fat diet. CONCLUSION It was concluded that LBPs are a potential complementary therapeutic alternative in the development of functional foods to curb obesity and obesity‐related diseases, such as metabolic syndrome. © 2021 Society of Chemical Industry

Study on the mechanism of Baihe Dihuang decoction in treating menopausal syndrome based on network pharmacology

“…Lily Bulbs have an excellent antioxidant capacity. [15,16] According to Kan et al [17] , Lily Bulbs Rehmannia inhibits adipocyte differentiation and adipogenesis. [18] It also plays an antioxidative role in improving the bone structure of osteoporosis rats by improving muscle atrophy.…”

Molecular cloning and structural characterization of PPARα gene from turbot ( Scophthalmus maximus ) and functional exploration of lipid metabolism in response to thermal stress

“…Previous studies have shown that selective PPARα agonists and overexpression of PPARα can partially inhibit FASN mRNA in HB2 cells (Iizuka et al, 2013), which is consistent with our research results. The latest research shows that when the expression of PPARα is upregulated, the expression of SCD is downregulated, which may also imply the negative regulatory effect of PPARα on FASN and SCD (Gong et al, 2021; Kan et al, 2021; Zhang et al, 2019).…”

“…Fat synthesis is an important pathway in the process of lipid FASN is focussed mainly on some diseases in mammals and humans (Menendez, 2007;Menendez et al, 2009). SCD is a key rate- that when the expression of PPARα is upregulated, the expression of SCD is downregulated, which may also imply the negative regulatory effect of PPARα on FASN and SCD (Gong et al, 2021;Kan et al, 2021;Zhang et al, 2019).…”

Research progress on the regulation of oxidative stress by phenolics: the role of gut microbiota and Nrf2 signaling pathway

“…38 A study found that phenolics from lily bulbs significantly reduced weight gain and oxidative damage in mice on a high-fat diet in a manner dependent on the dose. 39 Chronic diseases have been shown to be linked to oxidative stress, and plant phenolics can act as antioxidants to combat these diseases. 40 Ferulic acid is a natural phytochemical with various biological activities, including anticarcinogenic, antidiabetic, hepatoprotective, cardioprotective, and neuroprotective properties.…”

“…43 In cellular experiments, phenolics in the lily bulb could block ROS production, alleviate oxidative stress, and reduce lipid accumulation in HepG2 cells. 39 Studies have shown that regularly consuming phenolics-rich beverages could also effectively control oxidative stress. Red wine phenolics have been found to ameliorate excess superoxide production induced by a high-fat diet in the pancreas, liver, and blood vessels.…”