Limbic white matter microstructure plasticity reflects recovery from depression

Subcallosal Cingulate Connectivity in Anorexia Nervosa Patients Differs From Healthy Controls: A Multi-tensor Tractography Study

“…in major depressive disorder e for which SCC DBS has been shown effective e revealed that lower forniceal FA values are associated with failure to achieve remission [70,71]. Although some studies show unaltered forniceal white matter in depression [72], future forniceal subregional analysis may help explain these discrepancies [73]. Although the mechanisms through which DBS exerts its impact are complex and incompletely understood [74], growing evidence supports a greater influence on diffuse white matter tracts, compared to gray matter, suggesting that methods focused on improving tract visualization, such as tractography, will be of great importance in DBS target planning in future [75].…”

Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults

“…Therefore, the myelin specific measure of MWF represents a significant step forward for the interpretability of white matter neuroimaging studies. A further explanation for those discrepancies is that age impacts on white matter microstructure (Lebel et al 2010) and neuroplasticity of the PHC (Bracht et al 2015b). Thus, it is possible that in our young sample changes predominantly occur in myelination which only has a subtle effect on FA (Song et al 2002), while findings in diffusion properties in elderly populations may be the result of different neuroplastic processes (e.g.…”

“…1, 2) were reconstructed according to previously described algorithms (Bracht et al 2015b; Metzler-Baddeley et al 2013; Jones et al 2013a). For reconstruction of the fornix, a coronal region of interest (ROI) was placed around the columns of the fornix four slices posterior to the anterior commissure (Bracht et al 2015b). For reconstruction of bilateral PHC one horizontal ROI was placed at the height of the most ventral point of the splenium, and a second ROI was placed four slices above.…”

“…Thus there may be an association between PA, structural remodelling of hippocampal pathways and clinical recovery. This assumption is supported by a longitudinal study in major depressive disorder (MDD) identifying age-dependent white matter microstructural changes to occur in the left PHC during the time-span from depression to remission in a sample that also significantly increased their AL (Bracht et al 2015b). In this study we exclusively focus on the pathways connecting to the hippocampus because these pathways may not only be associated with PA but PA may also impact on structural alterations in neuropsychiatric disorders such as schizophrenia, depression or dementia thereby potentially reversing structural alterations and leading to clinical improvements.…”

Neuroimaging as a biomarker in symptom validity and performance validity testing

“…Considerable attention has been directed to how white matter integrity and connectivity are factors in affective disorder (Bracht et al 2014;Nave and Ehrenreich 2014;Ota et al 2014) as well as in disorders where apathy may occur (Kamat et al 2014). Imposing injury either as an emotional trauma that occurs in PTSD or physical trauma related to acceleration/deceleration, blunt force or blast, white matter is vulnerable to injury, ranging from not apparent or minimal (Ilvesmaki et al 2014) to distinctly demonstrable microstructural abnormalities Waljas et al 2014).…”