2024
DOI: 10.3748/wjg.v30.i46.4947
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Limitations and suggestions for type 2 diabetes mellitus and pancreatic neuroendocrine tumors based on meta-analysis

Wei Huang,
Yi-Qi Huang,
Guo-Li Yang

Abstract: We read with great interest the systematic review and meta-analysis by Cigrovski Berkovic et al published recently, which evaluated the association between type 2 diabetes mellitus (T2DM) and pancreatic neuroendocrine tumors (pNETs). The study identified T2DM as a risk factor for the development of pNETs and linked it to poor tumor-free survival. However, due to the limited number of studies and high heterogeneity, the role of metformin in the diagnosis and prognosis of pNETs remained inconclusive. We believ… Show more

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