Limited clinical significance of tissue calprotectin levels in bowel mucosa for the prediction of complicated course of the disease in children with ulcerative colitis

Fabián, Ondřej; Hradský, Ondřej; Lerchova, Tereza; Mikus, F; Zámečnı́k, Josef; Bronský, Jiří

doi:10.1016/j.prp.2019.152689

Cited by 13 publications

(15 citation statements)

References 27 publications

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“…have their own limitations, which makes the nursing care of patients with UC complicated (Tsilidis et al, 2008;Henderson et al, 2015;Mosli et al, 2015;D'Angelo et al, 2017;Fabian et al, 2019). Recently, miRNA in circulation and feces has become a potential non-invasive biomarker for monitoring disease activity of IBD patients, and it is significantly related to endoscopic activity.…”

Section: Mirnas Are Specifically Expressed In Ulcerative Colitis Mirnas As Biomarkers For Diagnosis Monitoring and Prognosis Of Ulcerativmentioning

confidence: 99%

miRNA-Based Potential Biomarkers and New Molecular Insights in Ulcerative Colitis

et al. 2021

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Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, which usually manifests as abdominal pain, diarrhea and hematochezia. The disease often recurs and is difficult to cure. At present, the pathogenesis is not clear, but it is believed that the disease is caused by a complex interaction among immunity, heredity, environment and intestinal microflora disorders. MicroRNA (miRNA) is endogenous single-stranded non-coding RNA of 17–25 nucleotides (nts). They target the 3'Untranslated Region of a target gene and inhibit or degrade the target gene according to the extent of complementary bases. As important gene expression regulators, miRNAs are involved in regulating the expression of most human genes, and play an important role in the pathogenesis of many autoimmune diseases including UC. Studies in recent years have illustrated that abnormal expression of miRNA occurs very early in disease pathogenesis. Moreover, this abnormal expression is highly related to disease activity of UC and colitis-associated cancer, and involves virtually all key UC-related mechanisms, such as immunity and intestinal microbiota dysregulation. Recently, it was discovered that miRNA is highly stable outside the cell in the form of microvesicles, exosomes or apoptotic vesicles, which raises the possibility that miRNA may serve as a novel diagnostic marker for UC. In this review, we summarize the biosynthetic pathway and the function of miRNA, and summarize the usefulness of miRNA for diagnosis, monitoring and prognosis of UC. Then, we described four types of miRNAs involved in regulating the mechanisms of UC occurrence and development: 1) miRNAs are involved in regulating immune cells; 2) affect the intestinal epithelial cells barrier; 3) regulate the homeostasis between gut microbiota and the host; and 4) participate in the formation of tumor in UC. Altogether, we aim to emphasize the close relationship between miRNA and UC as well as to propose that the field has value for developing potential biomarkers as well as therapeutic targets for UC.

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Section: Mirnas Are Specifically Expressed In Ulcerative Colitis Mirnas As Biomarkers For Diagnosis Monitoring and Prognosis Of Ulcerativmentioning

confidence: 99%

miRNA-Based Potential Biomarkers and New Molecular Insights in Ulcerative Colitis

et al. 2021

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“…In addition, some of the studies failed to take confounding factors into consideration and adapt their design and/or analysis accordingly. [12][13][14][15][16][17] The follow-up was considered complete enough and of suitable duration in most of the cases, and the results were deemed to be believable in general.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Twenty-nine composite outcomes were registered from a total of 28 studies [12][13][14][15][17][18][19][20][21][22][23][27][28][29][30][32][33][34][35][36][37][38][39][40][41][42][43][44] and five aggregate outcomes from five studies. 16,[24][25][26]31 The outcomes where heterogeneous in terms of the reporting of predefined variables considered here: the variable Hospitalization was reported in 17 outcomes, 13,15,17,18,20,23,26,30,32,33,35,36,39,41,44 Surgery in 22 outcomes, [13]…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Composite outcomes in observational studies of ulcerative colitis: A systematic review and meta‐analysis

et al. 2021

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Background: Ulcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes.Objective: This systematic review and meta-analysis aims to identify composite and aggregate outcomes of observational studies in UC and to evaluate how the number and type of variables included and the length of follow-up affect the frequency of patients that achieve these outcomes.Methods: A systematic literature search was carried out using MEDLINE [via PubMed], Scopus, and Web of Science online databases. Observational studies that included UC patients and reported composite or aggregate outcomes were identified. A set of variables considered to be representative of progressive or disabling UC was defined, the proportion of patients attaining the outcomes was determined and a random-effects meta-analysis was performed by dividing the identified studies into subgroups according to different criteria of interest.Results: A total of 10,264 records were identified in the systematic search, of which 33 were retained for qualitative analysis and 20 were included in the meta-analysis.The mean frequency for composite outcomes was 0.363 [95% confidence interval (CI) 0.323-0.403]. The frequency of composite outcome for the subgroup of studies that included the variable "Biologics" was significantly higher than for those in which this variable was not reported [0.410; 95% CI 0.364-0.457 versus 0.298; 95% CI 0.232-0.364; p = 0.006]. Composite outcomes were also more frequent as the follow-up duration increased. Conclusion:The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported. Moreover, longer

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“…Validated histologic indices, such as the Nancy Index and the Robarts Histopathology Index, are useful in assessing disease severity, but are often only available several days following colonoscopy with biopsy; thus their utility in guiding clinical manage- [83]. Intramucosal calprotectin, which can be identified using immunohistochemical staining, has found to be an independent predictor of disease severity [84], though it has not been found to be strongly associated as fecal calprotectin [85]. Again, delays in obtaining pathologic specimen results limit clinical usefulness of histologic findings in predicting outcomes in patients with ASUC.…”

Section: Predictors Of Poor Outcomesmentioning

confidence: 99%

Management of Hospitalized Patient with Ulcerative Colitis Refractory to Corticosteroids

Rabinowitz

Gold

Maser

2021

Management of Inpatient Inflammatory Bowel Disease

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Limited clinical significance of tissue calprotectin levels in bowel mucosa for the prediction of complicated course of the disease in children with ulcerative colitis

Cited by 13 publications

References 27 publications

miRNA-Based Potential Biomarkers and New Molecular Insights in Ulcerative Colitis

miRNA-Based Potential Biomarkers and New Molecular Insights in Ulcerative Colitis

Composite outcomes in observational studies of ulcerative colitis: A systematic review and meta‐analysis

Management of Hospitalized Patient with Ulcerative Colitis Refractory to Corticosteroids

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