Limited joint mobility in diabetes

Aljahlan, Mohammad; Lee, Kwok-Choy; Toth, Ellen L.

doi:10.3810/pgm.1999.02.536

Cited by 35 publications

(21 citation statements)

References 17 publications

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“…8 However, the properties and design of some reusable pens, such as maximum dose, body color differentiation, injection force, and dose knob dial extension, may represent limitations to some patients. For example, because manual dexterity disorders are common in people with diabetes and may limit finger or hand strength and the ability to inject insulin without assistance, 9 the issue of injection force is of particular concern. A pen with a reduced injection force would have several potential advantages.…”

Section: Introductionmentioning

confidence: 99%

Performance of a New Reusable Insulin Pen

Penfornis

2011

Diabetes Technology & Therapeutics

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Background: The aim of this multinational (Canada, France, Germany, United Kingdom, and United States), task and interview-based study was to compare the ease of use and performance of the ClikSTAR Ò (sanofi-aventis, Paris, France) insulin pen with other commonly used reusable pens based on participant and interviewer assessments. Methods: People with diabetes (n ¼ 654) were asked to demonstrate four pens consecutively-ClikSTAR, Lilly Luxura Ò (Eli Lilly, Indianapolis, IN), and NovoPen Ò 3 and 4 (Novo Nordisk, Bagsvaerd, Denmark)-according to the respective instruction manuals. The endpoint was assessed by a rating from the participants and the interviewer. While the participants focused on the pen's ease of use, the interviewer considered the participants' difficulty in preparing and delivering a 40-unit dose and their requirement for help. Results: Twenty percent of U.S. participants and 24% of participants from the other countries had type 1 diabetes. Approximately 50% of participants in each group had prior insulin pen experience. A higher proportion of participants, including those with dexterity or visual impairments, reported ClikSTAR as easier to use than other pens (P < 0.05). Participants using ClikSTAR did not experience any difficulty in completing the tasks. The proportion of participants not requiring help in completing the tasks with ClikSTAR was rated as numerically higher than, or similar to, that observed with Lilly Luxura or NovoPen 3 or 4 (75%, 74%, 62%, and 65%, respectively). According to participants, ClikSTAR and NovoPen 4 emerged as the most highly rated pens. Conclusions: In comparison with other pens, ClikSTAR was significantly easier to use, which, when taken together with overall performance, meets the need of people with diabetes.

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Section: Introductionmentioning

confidence: 99%

Performance of a New Reusable Insulin Pen

Penfornis

2011

Diabetes Technology & Therapeutics

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“…A contracture imposes limitations on the patient and carries a heavy medical and financial burden for society. 4,10,12,13,19,20,24,30,31,[40][41][42]57 New research approaches are needed to combat joint contractures. We found no literature on a possible genetic susceptibility to joint contractures in adults.…”

Section: Discussionmentioning

confidence: 99%

Genetic Influences on Joint Contractures Secondary to Immobilization

Laneuville¹,

Zhou²,

Uhthoff³

et al. 2007

Clinical Orthopaedics &Amp; Related Research

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The primary research question of this study queries whether, beyond environmental conditions, genetic factors affect the development of joint contractures. We hypothesized that intrinsic genetic factors influence the severity of joint contractures developing secondary to joint immobilization. Forty rats from four inbred rat strains had one leg immobilized in knee flexion for 4 weeks. The contracture was measured mechanically as the lack of range of motion to a standardized torque. Using the contralateral leg as a control, the average severity of the contracture could be calculated and compared between strains. All immobilized legs presented knee contractures after 4 weeks of immobilization. Two strains (Dark Agouti and Fisher 344) showed a larger mean knee contracture than those of the two other rat strains (Augustus Copenhagen Irish and Brown Norway). Environmental factors, such as immobility, are usually identified as a cause of a joint contracture. These results demonstrate that, in addition to mechanical factors in the environment of a joint, intrinsic genetic factors participate in the process leading to joint contracture. This demonstration has important consequences for directing future research and may lead to interventions to help patients at risk of developing joint contractures.

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“…Ces AGE provoquent un enraidissement des fibres de collagène proche d'une caramélisation (« brownisation ») [1,2], responsable d'une perte progressive des propriétés physicochimiques du collagène, notamment sa transparence pour le cristallin cataracte ou son élasticité pour les parois artérielles -microangiopathie -ou les structures articulaires et périarticu-laires -syndrome d'enraidissement articulaire (SEA) [3,[4][5][6]. Ce dépôt est d'autant plus intense que l'hyperglycémie est ancienne et prolongée ; elle n'est pas réversible, même après équilibration du diabète.…”

Section: Syndromes D'enraidissement Articulaireunclassified

Complications musculosquelettiques du diabète

Fautrel¹

2011

Revue du Rhumatisme Monographies

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Limited joint mobility in diabetes

Cited by 35 publications

References 17 publications

Performance of a New Reusable Insulin Pen

Performance of a New Reusable Insulin Pen

Genetic Influences on Joint Contractures Secondary to Immobilization

Complications musculosquelettiques du diabète

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