2016
DOI: 10.1007/s00246-016-1521-5
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Limited Ventricular Preload is the Main Reason for Reduced Stress Reserve After Atrial Baffle Repair

Abstract: The atrial baffle repair (ABR) significantly improved the fate of patients with transposition of the great arteries (TGA). However, these patients show impaired exercise tolerance and some present severe decline of systemic ventricular function. Intrinsic myocardial weakness, low heart rate response to exercise and diastolic filling impairment are discussed to be causative. Forty-nine long-term survivors with TGA (median age 23.7 year) after ABR were catheterized with measured oxygen consumption in four condit… Show more

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Cited by 10 publications
(5 citation statements)
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“…Recent investigations have shown a preserved inotropic state 5 . In addition, impaired ventricular filling following inflow correction has been documented 6,7 .…”
Section: Discussionmentioning
confidence: 99%
“…Recent investigations have shown a preserved inotropic state 5 . In addition, impaired ventricular filling following inflow correction has been documented 6,7 .…”
Section: Discussionmentioning
confidence: 99%
“…This could be a major limitation of the parameter, especially in patients with TGA after atrial switch procedure, in whom significant filling abnormalities through surgical baffles may exist. 23,24 Assessment of the SAVVR is also a crucial component of the echocardiographic evaluation of patients with sRV, as it has been shown to interplay with sRV dysfunction. 10 In TGA patients, SAVVR is attributed to annular dilatation and sRV dysfunction; therefore, replacement of the SAVV is usually not required.…”
Section: Namentioning
confidence: 99%
“…Another disadvantage is that the method is not valid with irregular rates, such as atrial fibrillation and elevated atrial pressure. This could be a major limitation of the parameter, especially in patients with TGA after atrial switch procedure, in whom significant filling abnormalities through surgical baffles may exist 23,24 …”
Section: Echocardiographymentioning
confidence: 99%
“…often stiff and non-contractile) will abnormally impact inflow characteristics. Thus, although important, standard inflow diastolic parameters generally remain non-applicable [ 25 , 26 ].…”
Section: Specific Considerations When Interpreting the Congenital Ech...mentioning
confidence: 99%