Limonoids and triterpenoid acids from the bark of Entandrophragma delevoyi

Phytochemistry and pharmacology of the genus Entandrophragma over the 50 years from 1967 to 2018: a ‘golden’ overview

“…A proposed biosynthetic scheme for formation of 99 and 100 might start with tirucallol as precursor to keep the same configuration and progress through a series of oxidation stages including Bayer-Villiger oxidation, some hydrolysis, reduction, and aldolisation including the formation of compound (94) as an intermediate product in the process. [31] Additional [119] 3 Epoxyazadiradione (nimbinin) [119] 6 [18] 7 [18] 8 [18] 9…”

“…Acyclic triterpenes also described as the squalene group triterpenes are particularly characteristical of the species E. cylindricum from their bark from which they have been reported so far and characterized as sapelenins AÀJ (116)(117)(118)(119)(120)(121)(122)(123)(124)(125) and ekeberin D2 (126) ( Figure 13). [4,[48][49][50] In general, their structures were elucidated using spectroscopic and spectrometric analyses as well as comparison of their data with those reported in literature.…”

“…Entandrolide E. angolense [126] 91 3,4-secotirucalla-4 (28),7,24-triene-3,21dioic acid R = COOH E. delevoyi [119] 92…”

“…Delevoyin A R = Me E. delevoyi [119] 93 3,4-secotirucalla-23-oxo-4(28),7,24-triene-3,21dioic acid (21-methyl ester)…”

“…Squalene-type triterpenoids from Entandrophragma(116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126).…”