LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells

Yang, Yong; Ren, Mingxin; Chen, Song; Li, Dan; Soomro, Shahid Hussain; Xiong, Yajie; Zhang, Hongfeng; Fu, Hui

doi:10.18632/oncotarget.20340

Cited by 41 publications

(43 citation statements)

References 60 publications

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“…LINC00707 overexpression promotes cell proliferation and migration in lung adenocarcinoma by regulating Cdc42 . LINC00461, a member of lncRNAs, is located at an intergenic region of the human chromosome 5 between two protein‐coding genes MEF2C and TMEM161B, respectively . LINC00461 has been reported to be one of the significantly up‐regulated lncRNAs in glioblastomas and metastatic prostate cancers .…”

Section: Discussionmentioning

confidence: 99%

Silencing of LINC00461 enhances radiosensitivity of lung adenocarcinoma cells by down‐regulating HOXA10 via microRNA‐195

Hou

Wang

Zhang

et al. 2020

J Cellular Molecular Medi

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Lung adenocarcinoma is recognized as one of the most recurrent tumours in adults. Long non‐coding RNAs (lncRNAs) are non–protein‐coding transcripts and have been demonstrated to regulate biological functions during tumorigenesis. Our study aims to investigate the underlying molecular mechanisms of LINC00461/microRNA‐195 (miR‐195)/HOXA10 responsible for its involvement in lung adenocarcinoma. We firstly selected differentially expressed lncRNAs and genes by the Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO). The functional role of LINC00461 in lung adenocarcinoma was then determined using ectopic expression, knockdown and reporter assay experiments. Besides, we detected the expression profiles of LINC00461, miR‐195, HOXA10 and apoptosis‐ and invasion‐related genes. Cell proliferation, migration and invasion were evaluated. In vivo tumour formation ability was analysed. Overexpressed LINC00461 and HOXA10 but down‐regulated miR‐195 were observed in primary and metastatic lung adenocarcinoma. LINC00461 negatively regulated miR‐195, while miR‐195 negatively regulated HOXA10. Forced LINC00461 expression decreased expression of miR‐195 and Bax, increased expression of HOXA10, MMP‐2, MMP‐9 and Bcl‐2, promoted cell proliferation, migration and invasion as well as tumour formation, and enhanced radiosensitivity of lung adenocarcinoma cells. However, these effects were reversed by lentivirus‐mediated miR‐195–forced expression, thereby suggesting that miR‐195 could antagonize the harmful effect of LINC00461 on lung adenocarcinoma cells. Collectively, the present study provides evidence supporting the inhibitory effect of LINC00461 silencing on lung adenocarcinoma, which suppresses lung adenocarcinoma cell migration, invasion and radiosensitivity via HOXA10 by binding to miR‐195, which provides a promising basis for the targeted intervention treatment for human lung adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Silencing of LINC00461 enhances radiosensitivity of lung adenocarcinoma cells by down‐regulating HOXA10 via microRNA‐195

Hou

Wang

Zhang

et al. 2020

J Cellular Molecular Medi

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“…[8][9][10] LINC00461 is a novel cancer-related lncRNA, transcribed from a gene located at an intergenic region of human chromosome 5. 11 However, the role of LINC00461 in BC is still unclear. 11 However, the role of LINC00461 in BC is still unclear.…”

Section: Introductionmentioning

confidence: 99%

LINC00461 promotes cell migration and invasion in breast cancer through miR‐30a‐5p/integrin β3 axis

Dong

Qian

Chen

et al. 2019

J of Cellular Biochemistry

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Mounting evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated and implicated in the occurrence and development of a wide range of human malignancies. LINC00461, a novel cancer‐related lncRNA, has been reported to be highly expressed and serve as oncogene in glioma; however, its biological role in breast cancer (BC) remains obscure. This study aimed to explore the role of LINC00461 in BC and elucidate the potential molecular mechanisms involved. In the current study, LINC00461 was found to be significantly upregulated in both BC tissues and cell lines. Besides, we found that high LINC00461 expression was associated with TNM stage and differentiation. Furthermore, functional studies demonstrated that LINC00461 expedited BC cell migration and invasion. Notably, LINC00461 was observed to enhance the expression of vimentin and zinc‐finger E‐box binding homeobox factor 1, suppress the expression of E‐cadherin, and promote the activation of extracellular signal‐regulated kinase and AKT signaling pathways. Mechanical investigations revealed that LINC00461 positively modulated integrin β3 (ITGB3) expression as miR‐30a‐5p sponge in BC cells. Taken together, LINC00461 exerts an oncogenic role in BC through miR‐30a‐5p/ITGB3 axis. Our data indicate that LINC00461 may be used to be a novel candidate therapeutic target and a valuable diagnostic biomarker for BC.

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“…Mounting studies have suggested the significant role of lncRNAs in the development of cancers, including NSCLC [14][15][16]. Herein, we selected LINC00461 for investigation because it has been demonstrated as an oncogene in multiple cancers, such as breast cancer, myeloma, and glioma [17][18][19]. In the present study, we firstly found that LINC00461 was up-regulated in NSCLC, and indicated poor prognosis.…”

Section: Discussionmentioning

confidence: 65%

“…The effect of lncRNAs on NSCLC has also been uncovered by mounting researches [14][15][16]. Long intergenic non-protein coding RNA 461 (LINC00461) demonstrated oncogenic performance in breast cancer, myeloma, and glioma [17][18][19], promoting cell growth, migration, and invasion, but it is not researched in NSCLC.…”

Section: Introductionmentioning

confidence: 99%

LINC00461/miR-4478/E2F1 feedback loop promotes non-small cell lung cancer cell proliferation and migration

2020

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Non-small cell lung cancer (NSCLC) is a prevalent subtype of lung cancer, whose mortality is high. Long non-coding RNAs (lncRNAs) have caught rising attentions because of their intricate roles in regulating cancerization and cancer progression. Long intergenic non-protein coding RNA 461 (LINC00461) has recently shown oncogenic potential in several cancers, but the function of LINC00461 in NSCLC remains to be investigated. Our study planned to unveil the regulatory role of LINC00461 in NSCLC. It was validated that LINC00461 was highly expressed in NSCLC tissues and cell lines and exhibited prognostic significance. Furthermore, LINC00461 expression in advanced stage was much higher than in early stage. Loss-of-function experiments suggested that LINC00461 knockdown impaired cell proliferation, migration, and epithelial-to-mesenchymal transition (EMT). Subcellular fractionation revealed the predominant location of LINC00461 in cytoplasm. Mechanistically, LINC00461 up-regulated E2F transcription factor 1 (E2F1) expression through sponging miR-4478. Besides, E2F1 bound to the promoter of LINC00461 to induce its transcription. Finally, rescue experiments verified that LINC00461 aggravated proliferation, migration, and EMT through targeting miR-4478/E2F1 axis. In consequence, the present study illustrated that LINC00461/miR-4478/E2F1 feedback loop promoted NSCLC cell proliferation and migration, providing a new prognostic marker for NSCLC.

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LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells

Cited by 41 publications

References 60 publications

Silencing of LINC00461 enhances radiosensitivity of lung adenocarcinoma cells by down‐regulating HOXA10 via microRNA‐195

Silencing of LINC00461 enhances radiosensitivity of lung adenocarcinoma cells by down‐regulating HOXA10 via microRNA‐195

LINC00461 promotes cell migration and invasion in breast cancer through miR‐30a‐5p/integrin β3 axis

LINC00461/miR-4478/E2F1 feedback loop promotes non-small cell lung cancer cell proliferation and migration

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