LINC00467: an oncogenic long noncoding RNA

Abstract

Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans. Recently, there is more and more interest in exploring the relationship between lncRNAs and tumors. Many latest evidences revealed that LINC00467, an oncogenic lncRNA, is highly expressed in lung cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, breast cancer, glioblastoma, head and neck squamous cell carcinoma, osteosarcoma, and other malignant tumors. Besides, LINC00467 expression was linked with proliferation, migration, invasion and apoptosis via the regulation of target genes and multiple potential pathways. We reviewed the existing data on the expression, downstream targets, molecular mechanisms, functions, relevant signaling pathways, and clinical implications of LINC00467 in various cancers. LINC00467 may serve as a novel biomarker or therapeutic target for the diagnosis and prognosis of various human tumors.

lncRNA Biomarkers of Glioblastoma Multiforme

“…LINC00467 (long intergenic non-protein coding RNA 467) is an oncogenic GBM lncRNA, and its expression correlates with the grade of glioma [72]. This lncRNA has been shown to be pro-inflammatory in association with some other malignancies such as gastric cancer, with its increase reported in lung cancer, breast cancer, colorectal cancer, hepatocellular carcinoma, osteosarcoma, head squamous cell carcinoma, and others [280]. LINC00467 is part of several signalling pathways including Akt, STAT, and EGFR, and its deregulation may contribute to pro-inflammatory mechanisms [281,282].…”