LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation

Wang, Yan; Dong, Tianfu; Wang, Peishun; Li, Shuqin; Wu, Geng; Zhou, Jun; Wang, Zhiqi

doi:10.1016/j.cellsig.2020.109808

Cited by 24 publications

(20 citation statements)

References 34 publications

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“…Through literatures retrieval, most of these genes were in connection with tumor invasion and metastasis. [32][33][34] For example, CDKL2 was reported to suppress cell growth and invasion and may predict a better prognosis, which was in accordance with our results as it negatively correlated with Radscore. 34 Despite lack of relevant study in NPC, our results indicated the feasibility of radiomics signatures in the prediction of gene expression, which is helpful to identify potential molecules and therapeutic intervention targets for tumors via noninvasive radiogenomics.…”

Section: Genomic Status and Radiomics Signaturesupporting

confidence: 92%

Magnetic resonance imaging‐based radiogenomics analysis for predicting prognosis and gene expression profile in advanced nasopharyngeal carcinoma

Gao

Mao

et al. 2021

Head & Neck

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Background: To establish a radiomics nomogram for survival prediction and determine if genomic data were related to radiomics signature in advanced nasopharyngeal carcinoma (NPC).Methods: Radiomics features were extracted from contrast-enhanced T1-weighted images (CE-T1WI) in 316 patients. A progression-free survival (PFS) nomogram was developed and validated by the combination of the radiomics signature and clinicopathologic factors. Whole transcriptomics sequencing was performed in pretreatment tumor samples; correlation of gene expression and radiomics signature was further investigated.Results: A 24-feature-combined radiomics signature was highly correlated with PFS; its integration with clinical predictors showed good prediction performance in the training and the validation cohort (C-index: 0.80 and 0.73). A significant correlation was observed between certain gene expression and Radscore, especially the mRNA expression of CDKL2, PLIN5, and SPAG1. Conclusion:As a noninvasive method, the MRI-based radiomics signature might enable the pretreatment prediction of prognosis and gene expressions profile in advanced NPC.

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Section: Genomic Status and Radiomics Signaturesupporting

confidence: 92%

Magnetic resonance imaging‐based radiogenomics analysis for predicting prognosis and gene expression profile in advanced nasopharyngeal carcinoma

Gao

Mao

et al. 2021

Head & Neck

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“…LINC00922 (ID: ENSG00000261742.5, long intergenic non-protein coding RNA 922) is a newly identified lncRNA. Studies have shown that LINC00922 has an important regulatory role in tumor invasion and migration (12,13). Previous studies mainly focused on detecting the expression of LINC00922 in ovarian cancer tissues and cells and studying the effect mechanism of LINC00922 on ovarian cancer (14).…”

Section: Pathological Diagnosis Has Shown That the Occurrence Of The Disease May Be Caused By Abnormal Immune Balancementioning

confidence: 99%

Increased LINC00922 in preeclampsia regulates the proliferation, invasion, and migration of placental trophoblast cells

Gao¹,

Yang²,

Xia³

2021

Ann Transl Med

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“…Cell motility and invasive behavior of gastric cancer cells is the critical mechanism underlying cancer metastasis [ 37 ]. Previous studies indicate that LINC00922 participates in metastasis regulation of breast cancer [ 23 ] and colorectal cancer [ 35 ]. In this study, we designed short hairpin RNA to interfere with the expression of LINC00922 in GC cells and performed scratch and transwell assays.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, LINC00922 promotes EMT by binding miR-361-3p in ovarian cancer [ 22 ]. In addition, LINC00922 can also activate the Wnt signaling pathway by promoting methylation of promoter NKD2, which in turn promotes invasion, migration, and EMT of breast cancer [ 23 ]. The above results suggested LINC00922 can be involved in regulating the EMT process as miRNA sponges or methylation regulators.…”

Section: Introductionmentioning

confidence: 99%

Upregulated LINC00922 Promotes Epithelial-Mesenchymal Transition and Indicates a Dismal Prognosis in Gastric Cancer

Chen

Mao

et al. 2022

Journal of Oncology

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Background. LINC00922 has been found to promote epithelial-mesenchymal transition (EMT) in a variety of tumors. But its functions in gastric cancer (GC) remain unclear. We attempt to investigate the correlation between LINC00922 and GC via bioinformatics analysis, in vitro and in vivo experiments. Methods. TCGA and GTEx databases were utilized to obtain the RNAseq and clinical data of GC, and then, identified the correlation of LINC00922 with patients’ clinicopathological characteristics and prognosis. GSEA and GO/KEGG enrichment analyses were performed to explore the potential functions or signaling pathways that LINC00922 participated in GC. Infiltration levels of immune cells were employed by ssGSEA algorithm, and then Wilcoxon rank sum test was applied to analyze their correlations with LINC00922. Scratch and transwell assays were conducted to detect the invasion and migration abilities of GC cells. Western blot was performed to explore the expression level of EMT-related proteins. Furthermore, we constructed the xenograft tumor model and metastatic tumor model in nude mice to explore the effect of LINC00922 downregulating on metastasis of GC cells in vivo. Results. Compared with normal tissues, LINC00922 was highly expressed in GC tissues and positively correlated with poor prognosis. The correlation existed between LINC00922 and immune infiltration in GC. Downregulation of LINC00922 inhibited the EMT process of GC cells. In addition, both in vitro and in vivo experiments showed that LINC00922 affects the invasion and migration abilities of GC. Conclusions. LINC00922 promotes the migration, invasion, and EMT in GC and has the potential to be used as a prognostic biomarker and therapeutic target for GC.

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LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation

Cited by 24 publications

References 34 publications

Magnetic resonance imaging‐based radiogenomics analysis for predicting prognosis and gene expression profile in advanced nasopharyngeal carcinoma

Magnetic resonance imaging‐based radiogenomics analysis for predicting prognosis and gene expression profile in advanced nasopharyngeal carcinoma

Increased LINC00922 in preeclampsia regulates the proliferation, invasion, and migration of placental trophoblast cells

Upregulated LINC00922 Promotes Epithelial-Mesenchymal Transition and Indicates a Dismal Prognosis in Gastric Cancer

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