Lineage diversification and recombination in type-4 human astroviruses

Martella, Vito; Medici, Maria Cristina; Terio, Valentina; Catella, Cristiana; Bozzo, Giancarlo; Tummolo, Fabio; Calderaro, Adriana; Bonura, Floriana; Franco, Marzia Di; Bányai, Krisztiàn; Giammanco, Anna; Grazia, Simona De

doi:10.1016/j.meegid.2013.09.015

Cited by 30 publications

(25 citation statements)

References 28 publications

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“…; Martella et al . ), we proposed the same scheme to classify MLB‐1 into two lineages. Considering the formation of two clusters with a strong bootstrap support in the study of a partial segment of ORF2 and nt diversity higher than 7% among the strains of these two clusters, the segregation of MLB‐1 strains circulating worldwide in two lineages named MLB‐1a and MLB‐1b was proposed here.…”

Section: Discussionmentioning

confidence: 99%

Environmental assessment reveals the presence of MLB-1 human astrovirus in Uruguay

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Environmental assessment reveals the presence of MLB-1 human astrovirus in Uruguay

et al. 2015

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“…Finally, subtypes or lineages have also been identified within each serotype, with a cutoff 93 to 95% nucleotide homology to a reference strain needed to be considered a new subtype (164)(165)(166)(167)(168). In light of this, HAstV-1 has so far been classified into 6 lineages (1a to 1f), HAstV-2 into 4 lineages (2a to 2d), HAstV-3 into 2 lineages (3a and 3b), and HAstV-4 into 3 lineages (4a to 4c) (166,(169)(170)(171)(172)(173)(174).…”

Section: Human Astrovirusesmentioning

confidence: 99%

“…Recombinations between different animal AstVs have also been described (152,155,162,183). Although most recombination breakpoints have been identified upstream of the conserved ORF1b/ORF2 junction region (155,168,172,182), they are also frequent within ORF2 (152,155,172,177), and they may also exist within ORF1a (155,181) and ORF1b (155,177,180).…”

Section: Figmentioning

confidence: 99%

Human Astroviruses

2014

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SUMMARY Human astroviruses (HAtVs) are positive-sense single-stranded RNA viruses that were discovered in 1975. Astroviruses infecting other species, particularly mammalian and avian, were identified and classified into the genera Mamastrovirus and Avastrovirus . Through next-generation sequencing, many new astroviruses infecting different species, including humans, have been described, and the Astroviridae family shows a high diversity and zoonotic potential. Three divergent groups of HAstVs are recognized: the classic ( MAstV 1 ), HAstV-MLB ( MAstV 6 ), and HAstV-VA/HMO ( MAstV 8 and MAstV 9 ) groups. Classic HAstVs contain 8 serotypes and account for 2 to 9% of all acute nonbacterial gastroenteritis in children worldwide. Infections are usually self-limiting but can also spread systemically and cause severe infections in immunocompromised patients. The other groups have also been identified in children with gastroenteritis, but extraintestinal pathologies have been suggested for them as well. Classic HAstVs may be grown in cells, allowing the study of their cell cycle, which is similar to that of caliciviruses. The continuous emergence of new astroviruses with a potential zoonotic transmission highlights the need to gain insights on their biology in order to prevent future health threats. This review focuses on the basic virology, pathogenesis, host response, epidemiology, diagnostic assays, and prevention strategies for HAstVs.

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“…Some recombinants appear to be highly stable and show widespread detection [21], whilst others are detected sporadically as single strains. Numerous human recombinant strains have been reported between HAstV strains, including strains with HAstV-1 (ORF1b) and HAstV-4 (ORF2) parental viruses, HAstV-1 (ORF1b) and HAstV-3 (ORF2) parental viruses, HAstV-3 (ORF1b) and HAstV-2 (ORF2), and VA2 (ORF1b) and MLB1 (ORF2) parental viruses [116,119,120,121]. …”

Section: Recombinationmentioning

confidence: 99%

The Broad Host Range and Genetic Diversity of Mammalian and Avian Astroviruses

Donato

Vijaykrishna

2017

Viruses

140

144

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Astroviruses are a diverse family of viruses that infect a wide range of mammalian and avian hosts. Here we describe the phylogenetic diversity and current classification methodology of astroviruses based on the ORF1b and ORF2 genes, highlighting the propensity of astroviruses to undergo interspecies transmission and genetic recombination which greatly increase diversity and complicate attempts at a unified and comprehensive classification strategy.

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Lineage diversification and recombination in type-4 human astroviruses

Cited by 30 publications

References 28 publications

Environmental assessment reveals the presence of MLB-1 human astrovirus in Uruguay

Environmental assessment reveals the presence of MLB-1 human astrovirus in Uruguay

Human Astroviruses

The Broad Host Range and Genetic Diversity of Mammalian and Avian Astroviruses

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