Lineage specification in the fly nervous system and evolutionary implications

Cattenoz, Pierre B.; Giangrande, Angela

doi:10.4161/cc.25918

Cited by 4 publications

(2 citation statements)

References 80 publications

(71 reference statements)

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“…Although the molecular mechanisms specific to type II lineage gliogenesis are poorly understood (Awasaki et al, 2008;Viktorin et al, 2011), gliogenesis has been widely studied in Drosophila and vertebrate nervous systems (Jones, 2005;Rowitch and Kriegstein, 2010). It has been shown that Notch signaling could either promote or repress gliogenesis, depending on the specific developmental context (Cattenoz and Giangrande, 2013;Chen et al, 2016;Gaiano and Fishell, 2002;Gho et al, 1999;Morrison et al, 2000;Udolph et al, 2001;Umesono et al, 2002;Van De Bor and Giangrande, 2001).…”

Section: Requirement Of Notch Signaling For the Gliogenic Switchmentioning

confidence: 99%

Lineage-guided Notch-dependent gliogenesis byDrosophilamulti-potent progenitors

et al. 2018

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Macroglial cells in the central nervous system exhibit regional specialization and carry out region-specific functions. Diverse glial cells arise from specific progenitors in specific spatiotemporal patterns. This raises an interesting possibility that glial precursors with distinct developmental fates exist that govern region-specific gliogenesis. Here, we have mapped the glial progeny produced by the type II neuroblasts, which, like vertebrate radial glia cells, yield both neurons and glia via intermediate neural progenitors (INPs). Distinct type II neuroblasts produce different characteristic sets of glia. A single INP can make both astrocyte-like and ensheathing glia, which co-occupy a relatively restrictive subdomain. Blocking apoptosis uncovers further lineage distinctions in the specification, proliferation and survival of glial precursors. Both the switch from neurogenesis to gliogenesis and the subsequent glial expansion depend on Notch signaling. Taken together, lineage origins preconfigure the development of individual glial precursors with involvement of serial Notch actions in promoting gliogenesis.

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Section: Requirement Of Notch Signaling For the Gliogenic Switchmentioning

confidence: 99%

Lineage-guided Notch-dependent gliogenesis byDrosophilamulti-potent progenitors

et al. 2018

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“…Along this direction, we recently unveiled a novel link 16 in the intriguing correlation occurring between the master gene gcm/glide and the RNA pathway. The fly transcription factor Gcm/Glide [17][18][19] constitutes a unique example of cell fate determinant, which dictates the glial vs. neuronal fate choice in multipotent fly neural precursors 20 . Twenty-year long research on this topic has clearly underlined the occurrence of multiple and overlapping inputs of gene expression regulation converging over gcm/glide [21][22][23][24][25][26][27][28] to establish the threshold levels required for balancing the delicate ratio between neuronal and glial counterparts during neural development.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Northern Blot Detection of Small RNA Species in <em>Drosophila Melanogaster</em>

Laneve

Giangrande²

2014

JoVE

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The last decades have witnessed the explosion of scientific interest around gene expression control mechanisms at the RNA level. This branch of molecular biology has been greatly fueled by the discovery of noncoding RNAs as major players in post-transcriptional regulation. Such a revolutionary perspective has been accompanied and triggered by the development of powerful technologies for profiling short RNAs expression, both at the high-throughput level (genome-wide identification) or as single-candidate analysis (steady state accumulation of specific species). Although several state-of-art strategies are currently available for dosing or visualizing such fleeing molecules, Northern Blot assay remains the eligible approach in molecular biology for immediate and accurate evaluation of RNA expression. It represents a first step toward the application of more sophisticated, costly technologies and, in many cases, remains a preferential method to easily gain insights into RNA biology. Here we overview an efficient protocol (Enhanced Northern Blot) for detecting weakly expressed microRNAs (or other small regulatory RNA species) from Drosophila melanogaster whole embryos, manually dissected larval/adult tissues or in vitro cultured cells. A very limited amount of RNA is required and the use of material from flow cytometry-isolated cells can be also envisaged. Video LinkThe video component of this article can be found at

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Functional Specification of a Primitive Bilaterian Brain in Planarians

Inoue

2017

Diversity and Commonality in Animals

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Lineage specification in the fly nervous system and evolutionary implications

Cited by 4 publications

References 80 publications

Lineage-guided Notch-dependent gliogenesis byDrosophilamulti-potent progenitors

Lineage-guided Notch-dependent gliogenesis byDrosophilamulti-potent progenitors

Enhanced Northern Blot Detection of Small RNA Species in <em>Drosophila Melanogaster</em>

Functional Specification of a Primitive Bilaterian Brain in Planarians

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