Theme unsuitability is noted to have inhibited the accuracy of groundwater potential zones (GWPZs) mapping approach, especially in a semi-arid environment where surface water supply is inadequate. This work, therefore presents a geoscience approach for mapping high-precision GWPZs peculiar to the semi-arid area, using Buffalo catchment, Eastern Cape, South Africa, as a case study. Maps of surficial-lithology, lineament-density, drainage-density, rainfall-distribution, normalized-difference-vegetation-index, topographic-wetness-index, land use/land cover, and land-surface-temperature were produced. These were overlaid based on analytical hierarchical process weightage prioritization at a constituency ratio of 0.087. The model categorizes GWPZs into the good (187 km2), moderate (338 km2), fair (406 km2), poor (185 km2), and very poor (121 km2) zones. The model validation using borehole yield through on the coefficient of determination (R2 = 0.901) and correlation (R = 0.949) indicates a significant replication of ground situation (p value < 0.001). The analysis corroboration shows that the groundwater is mainly hosted by a fractured aquifer where the GWPZs is either good (9.3 l/s) or moderate (5.5 l/s). The overall result indicates that the model approach is reliable and can be adopted for a reliable characterization of GWPZs in any semi-arid/arid environment.