Linear accelerator radiosurgery in treatment of central neurocytomas

Martín, J.M.; Katati, Majed J.; López, Escarlata; Bullejos, J.A.; Arregui, G.; Busquier, Heriberto; Mínguez, Adolfo; Olivares, Gonzalo Quintero; Hernández, V.; Arjona, V.

doi:10.1007/s00701-003-0076-4

Cited by 32 publications

(21 citation statements)

References 25 publications

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“…Some authors (Kobayashi et al, 2001, Kim et al, 2007 propose GKRS as primary treatment without histological diagnosis when a deep-seated or critically located brain tumor showing the imaging characteristics of an unusual LGPNTs is identified. On the contrary, other collegues state that obtaining a histological diagnosis remains the main aim for rational treatment planning (Matsunaga et al, 2010;Martin et al, 2003;Yen et al, 2007;Tyler-Kabara et al, 2001;Kano et al, 2009d;Lekovic et al, 2007;Reyns et al, 2007;Dershmukh et al, 2004). In our series,all tumors were histologically verified before GKRS.…”

Section: Overall Seriesmentioning

confidence: 99%

“…Its features match those of oligodendroglioma or ependymoma, leading to frequent misdiagnosis when further investigations are not performed. Immunohistochemistry is very useful for the diagnosis of neurocytoma, which shows a dot-like positivity for synaptophysin, negativity for glial fibrillary acidic protein and constant expression of neuron-specific enolase (Martin et al, 2003). Typical neurocytomas are characterized by a MIB-1 labeling index ≤3% and the absence of histologic atypia (Rades & Schild, 2006).…”

Section: Central Neurocytoma (Cn)mentioning

confidence: 99%

“…But, tumors in more than half of patients with CN cannot be completely resected. Furthermore, recurrences, even after complete resection, and tumor progression after subtotal resection have been reported up to 33% of cases (Matsunaga et al, 2010, Kim et al, 2007, Yen et al, 2007, Martin et al, 2003, Cobery et al, 2001). Finally, malignant transformation is known to occur in a few cases, resulting in tumor progression, intracerebral hemorrhage, or craniospinal dissemination (Matsunaga et al, 2010).…”

Section: Central Neurocytoma (Cn)mentioning

confidence: 99%

“…The results showed effective local tumor control. However, because of the benign clinical course of CN, the young mean age of the affected patients and the well-known long-term adverse effects of conventional RT, such as cognitive dysfunction and secondary tumor formation, routine use of conventional RT for residual or recurrent CN has been critized by several authors (Kim et al, 2007, Yen et al, 2007, Martin et al, 2003. The advantage of a focused radiation is that a high dose with a steep fall off in radiation can be delivered precisely in one single treatment session.…”

Section: Central Neurocytoma (Cn)mentioning

confidence: 99%

“…Only in one patient, a radiosurgery-related clinical worsening occurred: she was treated with a 6 MV LINAC system for a 8.09 cc left lateral ventricle CN. Radiation necrosis and brain edema were developed and ventriculo-peritoneal shunt was needed (Martin et al, 2003). The overall survival reported by the different authors varies between 67% and 100%, but none of the patients died due to the tumor progression.…”

Section: Central Neurocytoma (Cn)mentioning

confidence: 99%

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Gamma Knife Radiosurgery in the Management of Unusual Grade I/II Primitive Neuroepithelial Tumours of the Brain

Nicolato¹,

Longhi²,

Foroni³

et al. 2011

Gamma Knife Radiosurgery

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Section: Overall Seriesmentioning

confidence: 99%

Section: Central Neurocytoma (Cn)mentioning

confidence: 99%

Section: Central Neurocytoma (Cn)mentioning

confidence: 99%

Section: Central Neurocytoma (Cn)mentioning

confidence: 99%

Section: Central Neurocytoma (Cn)mentioning

confidence: 99%

See 3 more Smart Citations

Gamma Knife Radiosurgery in the Management of Unusual Grade I/II Primitive Neuroepithelial Tumours of the Brain

Nicolato¹,

Longhi²,

Foroni³

et al. 2011

Gamma Knife Radiosurgery

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Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas

Rades

Schild

2006

Cancer

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BACKGROUNDTwo groups of central neurocytomas have been identified: typical and atypical neurocytomas. The more benign typical neurocytomas have a better prognosis. Complete resection of typical neurocytomas results in significantly better outcome than incomplete resection. The current study investigated whether the outcome after incomplete resection can be improved by postoperative stereotactic radiosurgery (SRS) or by conventional radiotherapy.METHODSThe data of all neurocytoma patients reported since 1997, when the first neurocytoma patient treated with SRS was described, were reviewed. Patients who underwent complete resection or those with atypical neurocytoma were excluded from the analysis. Three different therapies were compared for overall survival (OS) and local control (LC): incomplete resection alone (ITR), ITR followed by conventional radiotherapy (ITR+cRT), and ITR followed by stereotactic radiosurgery (ITR+SRS).RESULTSData were complete in 121 patients (59 ITR, 41 ITR+cRT, and 21 ITR+SRS). The 5‐year‐LC after ITR was 51%. LC was significantly better after ITR+cRT (87%, P = 0.001) and after ITR+SRS (100%, P = 0.004). The difference between ITR+cRT and ITR+SRS was not significant (P = 0.45). The 5‐year‐OS was 93% after ITR, 100% after ITR+cRT, and 100% after ITR+SRS. The differences between the various groups were not significant. The P‐values were 0.13 for ITR versus ITR+cRT, 0.29 for ITR versus ITR+SRS, and 1.0 for ITR+cRT versus ITR+SRS.CONCLUSIONSAfter ITR of typical neurocytomas, LC is significantly improved by both conventional radiotherapy and SRS. The results of both radiation treatments were similar. SRS is a reasonable alternative to conventional radiotherapy in selected patients. Cancer 2006. © 2006 American Cancer Society.

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Gamma knife radiosurgery for central neurocytoma

Kim

Paek

Jeong

et al. 2007

Cancer

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BACKGROUND.Little is known about long‐term results of gamma knife (GK) stereotactic radiosurgery (SRS) as a primary or a secondary postoperative therapy for central neurocytomas (CNs). The authors retrospectively reviewed long‐term outcomes of 13 patients with CN treated with GK SRS.METHODS.Thirteen patients were treated with GK SRS as a primary (6 patients) or a secondary postoperative therapy (7 patients). Follow‐up clinical status and brain magnetic resonance imaging (MRI) were thoroughly analyzed. The functional status of patients was assessed with the Karnofsky Performance Scale during follow‐up.RESULTS.The median follow‐up period for clinical status and imaging studies was 61 months (range, 6 months to 96 months). Tumors decreased in 5 patients who received GK SRS as a primary treatment. However, the tumor recurred in 2 patients treated with a secondary GK SRS after surgery from the residual tumor bed that was not covered by the GK SRS. Parenchymal changes and secondary malignancies were not found in follow‐up MRIs of all 13 patients. The Karnofsky Performance Scale score of all patients, except for 1 patient who suffered from an unrelated anteriorly communicating arterial aneurysmal rupture, did not change after GK SRS.CONCLUSIONS.GK SRS may be useful as a primary or a secondary postoperative therapy for the treatment of CN. However, more attention should be paid to residual or recurrent CN during treatment, and regular long‐term follow‐up MRI should be mandatory to validate the procedure. Cancer 2007 © 2007 American Cancer Society.

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Linear accelerator radiosurgery in treatment of central neurocytomas

Abstract: In cases of small residual tumours or recurrences radiosurgery allows open surgery to be avoided and is a safe and potentially effective approach.

Cited by 32 publications

References 25 publications

Gamma Knife Radiosurgery in the Management of Unusual Grade I/II Primitive Neuroepithelial Tumours of the Brain

Gamma Knife Radiosurgery in the Management of Unusual Grade I/II Primitive Neuroepithelial Tumours of the Brain

Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas

Gamma knife radiosurgery for central neurocytoma

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