1994
DOI: 10.1099/0022-1317-75-6-1353
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Linear antigenic and immunogenic regions of the respiratory syncytial virus P protein

Abstract: Three linear antigenic regions on the P protein from human respiratory syncytial virus (RSV) subgroup A (strain A2) were represented by peptides that reacted with monoclonal antibodies and with sera from humans with recent or previous RSV infection. The determinants were localized within three hydrophilic regions of the P protein: Prog~ to AspH0, Ser16~ to LySls 0 and Glu221 to Phe241. The role of individual amino acids in the epitopes defined by monoclonal antibodies was determined. Two monoclonal antibodies … Show more

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Cited by 4 publications
(6 citation statements)
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“…Recently we reported similar studies of the RSVP protein (Leonov et al, 1994). In the present study, we identified three immunodominant linear antigenic regions by use of synthetic overlapping peptides representing the RSV N protein.…”
Section: Introductionmentioning
confidence: 66%
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“…Recently we reported similar studies of the RSVP protein (Leonov et al, 1994). In the present study, we identified three immunodominant linear antigenic regions by use of synthetic overlapping peptides representing the RSV N protein.…”
Section: Introductionmentioning
confidence: 66%
“…ELISA with purified RSV antigen and peptides was performed as previously described (Akerlind-Stopner et al, 1990;Leonov et al, 1994). The results were expressed either as A492 (mean of three determinations) or, for substituted peptide analogues, as the percentage of peptides binding.…”
Section: Methodsmentioning
confidence: 99%
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