Linear free energy relationship analysis of microemulsion electrokinetic chromatographic determination of lipophilicity

Abraham, Michael H.; Treiner, Claude; Rosés, Martı́; Ràfols, Clara; Ishihama, Yasushi

doi:10.1016/s0021-9673(96)00518-3

Cited by 97 publications

(69 citation statements)

References 18 publications

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“…The MEEKC migration time, or retention factor, of a neutral solute can be directly related to the solubility (hydrophobicity) of the solute. MEEKC has been used [3][4][5] to assess compound solubility with good cross-correlation to other techniques used to measure solubility.…”

Section: Introductionmentioning

confidence: 99%

Background and operating parameters in microemulsion electrokinetic chromatography

2003

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Microemulsion electrokinetic chromatography (MEEKC) is an electrodriven separation technique. Separations are generally achieved using microemulsions consisting of surfactant-coated nanometer-sized oil droplets suspended in aqueous buffer. A cosurfactant such as a short-chain alcohol is generally used to stabilize the microemulsion. This review summarizes the various microemulsion types and compositions that have been used in MEEKC. The effects of key-operating variables such as surfactant type and concentration, cosurfactant type and concentration, buffer pH and type, oil type and concentration, use of organic solvent and cyclodextrin additions, and temperature are described. Specific examples of water-in-oil microemulsions and chirally selective separations are also covered.

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Section: Introductionmentioning

confidence: 99%

Background and operating parameters in microemulsion electrokinetic chromatography

2003

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“…This model, proposed by Abraham et al [63][64][65][66], provides information on the relative strengths of various chemical interactions between a PSP and solutes. The model is expressed by the following equation:…”

Section: Lsermentioning

confidence: 99%

Retention behavior and selectivity of a latex nanoparticle pseudostationary phase for electrokinetic chromatography

et al. 2011

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The retention characteristics and separation selectivity of a novel latex nanoparticle (NP) pseudostationary phase (PSP) for electrokinetic chromatography have been characterized. The anionic NPs have very low or no affinity for cationic solutes, but show significant interactions and retention based on hydrophobic interactions. Retention factors of alkyl-phenyl ketones increase linearly with the concentration of the NPs and have zero or near zero y-intercepts as expected for electrokinetic chromatography with non-micellar PSPs. The retention factors of these solutes and representative pharmaceuticals decrease logarithmically with increases in the concentration of ACN in the background electrolyte, as expected for reversed-phase retention. Linear solvation energy relationship analysis indicates that the NPs are less cohesive than would be expected for polymeric PSPs with similar structure but that the overall separation selectivity can be expected to be similar to polymer PSPs with similar backbone chemistry. The results indicate that the hydrophobic core of the NPs is non-cohesive and is highly accessible to solutes, whereas the ionic head groups are not as accessible and do not contribute substantially to retention or selectivity.

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“…MEEKC has found wide use [10,[22][23][24][33][34][35][36][37][38][39][40] for the determination of the lipophilicity of chemical substances. This is due to the many advantages of MEEKC compared to HPLC and to the shake flask method.…”

Section: Partition Coefficientsmentioning

confidence: 99%

Recent applications of microemulsion electrokinetic chromatography

Hansen

2003

Electrophoresis

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Microemulsions are used in a similar way as micellar solutions are used for separations in capillary electrophoresis. Within the last approximately six years, a number of papers have appeared in the literature in which the separation characteristics of microemulsion electrokinetic chromatography (MEEKC) have been investigated. The total number of papers dealing with MEEKC is now close to 100. One of the major fields of application for MEEKC has been the characterization of the lipophilicity of chemical substances but the technique has also been applied for the analysis of substances within the fields of natural products, pharmaceuticals, vitamins, peptides, proteins, and nucleic acid bases as well as nucleosides. An overview of the applications is given together with the microemulsions used for each application.

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Linear free energy relationship analysis of microemulsion electrokinetic chromatographic determination of lipophilicity

Cited by 97 publications

References 18 publications

Background and operating parameters in microemulsion electrokinetic chromatography

Background and operating parameters in microemulsion electrokinetic chromatography

Retention behavior and selectivity of a latex nanoparticle pseudostationary phase for electrokinetic chromatography

Recent applications of microemulsion electrokinetic chromatography

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