Linear IgA dermatosis with IgA and IgG autoantibodies to the 180 kDa bullous pemphigoid antigen (BP180): evidence for a distinct subtype

Abstract

These data provide evidence for the presence of a subtype of LAD with dual IgA and IgG autoimmune response to BP180.

Recombinant Human IgA1 and IgA2 Autoantibodies to Type VII Collagen Induce Subepidermal Blistering Ex Vivo

“…However, this study did not show that MIP8a has no side effects on DES by IgG autoantibodies, because FcaRI has both inhibitory and activatory functions (52). These might affect DES by IgG autoantibodies that are often also present in LABD (36)(37)(38).…”

“…Using unpurified sera from LABD patients in an ex vivo model, the inhibition of FcaRI by the MIP8a mAb was shown to abolish leukocyte-dependent dermal-epidermal separation (DES) (35). However, non-IgA Abs in the patient sera may have interfered with this assay, because the autoantibodies in LABD are not restricted to the IgA isotype (36)(37)(38). In addition, because IgA is generally regarded as having only a weak ability to activate the complement system, these Abs may lack an important mechanism for the recruitment of neutrophil granulocytes to the site of autoantibody binding (28).…”

A necessidade da imunofluorescência direta no diagnóstico da dermatose bolhosa por IgA

“…Quanto aos títulos de IgA circulante, constatam-se, aproximadamente, 60% a 70% de IFD positivas (4) . Em até 25% dos casos, pode-se demonstrar também a presença de anticorpo IgG, juntamente com IgA, na ZMB nas DbIgA, fornecendo evidências de um subtipo de DbIgA com resposta autoimune dual de IgA e IgG contra o BP180 (8,14) . Do ponto de vista clínico, não há diferenças entre os tipos apenas com marcação para IgA daqueles com expressão de IgA e IgG; este último contribui menos frequentemente para o tipo infantil em relação ao adulto (5) .…”

Dermatose por IgA e IgG linear: relato de caso com boa resposta terapêutica à dapsona e ao micofenolato mofetil

“…The rea son for such simi la rity has been attri bu ted to the fact that IgA is an anti body with very hete ro ge neous tar get anti gens, against seve ral BM com po nents. A pos si ble mecha nism of inter mo le cu lar expan sion of epi to pes could be res pon si ble for the autoim mu nity exten sion of BP180 anti gen to the BP230 anti gen. 3,[5][6][7][8]11 In con trast, IgG seems to have a much more res tric ted res pon se. 3 In this study is pre sen ted a LAGD case com plica ted by mala ria, but with good res pon se to the treatment with dap so ne and myco phe no la te mofe til.…”

“…5 Subsequent reports cor ro bo ra te the findings of this group. 3,[6][7][8] The pre sen ce of simul ta neous linear depo si tion of IgA and IgG was fun da men tal for the con cep tion of a new cli ni cal-patho lo gi cal entity, IgA and IgG linear der ma to sis (LAGD). 9,10 However, the mag ni tu de and cli ni cal rele van ce of this clas si fi ca tion remain con trover sial, as there seems to be no dif fe ren ces in the derma to lo gi cal pre sen ta tion and the ra peu tic spec trum of both disea ses.…”