Linear Lesions Provide Protection from Atrial Fibrillation Induction with Rapid Atrial Pacing

Abstract

In this animal model of AF, LL are not only capable of terminating chronic AF, but also lead to self-termination of AF once the rapid pacing is stopped. Self-termination of AF after induction with rapid pacing was not observed in this AF model in the absence of LL. In the dogs with 6 months of AF, the presence of AF led to increased atrial susceptibility to AF induction by rapid pacing, even with LL and after 6 months of recovery. Incomplete LL allows induction of atrial tachycardia and AF.

Left Atrial Ablation Versus Biatrial Ablation for Persistent and Permanent Atrial Fibrillation

“…Recently, Sanders et al Calò et al June 20, 2006June 20, :2504 Left and Right Atrial Ablation in Atrial Fibrillation (37) observed that in patients with paroxysmal AF dominant sources of activity are often localized to the PVs, and, in contrast in patients with permanent AF, these dominant frequency sites are more often localized to the atria, including right atrial sites (37). Combined left and right atrial linear ablation has been shown to eliminate chronic AF in animal models (11)(12)(13)(14)(15) and, specifically, two experimental studies demonstrated that biatrial ablation is more effective than right and left atrial ablation alone to cure chronic AF (14,15). In humans, the Maze procedure, characterized by lesions in both atria, was effective in maintaining sinus rhythm in 99% of patients with chronic AF (38).…”

The Role of Platelet-Derived Growth Factor-B/Platelet-Derived Growth Factor Receptor-β Signaling in Chronic Atrial Fibrillation

“…Persistent spontaneous AF was defined as AF lasting more than 30 min after the cessation of atrial pacing [20]. As soon as persistent spontaneous AF was detected, the duration of AF was calculated.…”

Past, Present and Future Catheter Technologies and Energy Sources for Atrial Fibrillation Ablation

“…Having multiple ablation electrodes on a single shaft allows for minimal catheter manipulation in creating long linear lesions and, therefore, may reduce both thromboembolic risk and radiation exposure. Once the catheter is in place, it remains in position for the duration of the power application to all of the electrodes (Avitall et al 2002). …”