Linear shock wave therapy in the treatment of erectile dysfunction

Pelayo-Nieto, M.; Linden-Castro, E.; Alías-Melgar, Alejandro; Grovas, D. Espinosa-Pérez; Rosa, F. Carreño-de la; Bertrand-Noriega, F.; Cortez-Betancourt, R.

doi:10.1016/j.acuroe.2015.06.009

Cited by 20 publications

(13 citation statements)

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“…Similarly, Bechara et al (7) reported that 3 out of 4 patients in severe ED group were irresponsive to LI-ESWT. In addition, the form of LI-ESWT protocol and treatment duration are controversial in many studies (8,17,18,19). However it has been reported that treatment lasting longer than six weeks did not have a positive effect on the results (23).…”

Section: Discussionmentioning

confidence: 99%

“…Pelayo-Nieto et al (8) applied LI-ESWT with 5000 shockwaves to 15 patients with mild-moderate ED once a week for four weeks and detected an increase of 5.46 (14.23-19.69) points in IIEF scores (p<0.013) and 33% recovery in patients with a EHS below 2 (p<0.01) in the evaluation they made at the end of the first month of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that only 20% of patients in this study (n=4) were in severe ED group and 3 out of 8 patients not responding to treatment (37.5%) were in severe ED group. 10.6 (7)(8)(9)(10)(11)(12)(13)(14) 9.35 (6-13) 0.1 3 rd month IIEF-EF score (median) 11.1 (7)(8)(9)(10)(11)(12)(13)(14) 10.8 ( Chung and Cartmill (18) reported that IIEF score increased ≥5 points in 60% of patients in the evaluation made six weeks later on 30 patients who received LI-ESWT (3000 shockwaves, 6 weeks, once in two weeks).…”

Section: Discussionmentioning

confidence: 99%

“…LI-ESWT (RENOVA, Direx Medical Systems, Israel) was applied once a week for four weeks in four different anatomic areas: the right and left corpus cavernosum and the right and left penile crura. The treatment was performed as follows: 5000 waves of 0.09 mJ/ mm 2 , 300 intensity waves/min (5 Hz), 40 mm deep, in four areas (cavernosum right, left waves on each side 900, and left and right crus waves 1600 on each side); each session lasting 20 min with a one-week interval between each session (7,8). 5 mg tadalafil treatment was orally started once a day in both groups and the treatment was continued for three months.…”

Section: Methodsmentioning

confidence: 99%

“…There are studies showing that low-intensity linear shockwave treatment (LI-ESWT) is effective and successful in patients with ED due to vascular disorders, especially in those with arteriogenic ED (6,7,8). It is claimed that LI-ESWT causes neovascularization by stimulating angiogenesis and increases endothelial cell proliferation (7,9).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Low Density Linear Shockwave Treatment in Severe Arteriogenic Erectile Dysfunction Patients

Sönmez¹,

Kara²

2017

jus

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Objective: The aim of this study was to evaluate the efficacy of low-intensity linear shockwave treatment (LI-ESWT) in patients with severe arteriogenic erectile dysfunction (ED) by comparing LI-ESWT combined with daily use of phosphodiesterase type 5 inhibitors (PDE5i) with the daily use of PDE5i alone. Materials and Methods: A total of 23 patients were included in the study. The patients were separated into two groups: LI-ESWT + tadalafil 5 mg (n=10) group and tadalafil 5 mg only group (n=13). LI-ESWT was applied once a week for four weeks. Oral tadalafil 5 mg once a day was started and continued for three months in both groups. The patients were evaluated with the International Erectile Function Index Questionnaire Erectile Function Domain (IIEF-EF), Erection Hardness Score (EHS) and Sexual Encounter Profile (SEP) 2 and 3 before treatment and the 1 and 3 months after treatment. Results: No statistically significant difference was detected among IIEF-EF scores measured before and 1 and 3 months after treatment (p=0. 091, p=0.198). At the end of the third month, IIEF score increased 4 points in LI-ESWT + tadalafil 5 mg group and 3.2 points in tadalafil 5 mg only group. No statistically significant difference was detected in EHS, and the rate of positive responses to SEP2 and SEP3 questions at the 1 st and 3 rd months between the groups. Conclusion: LI-ESWT is easily applicable without any significant side effects and it has positive effects on the outcomes, however, it is not an effective treatment method in patients with severe arteriogenic ED. Keywords: Low-intensity linear shockwave treatment, phospodiesterase type 5 inhibitors, erectile dysfunction Amaç: Bu çalışmanın amacı, şiddetli arteriyojenik erektil disfonksiyona (ED) sahip hastalarda, fosfodiesteraz tip 5 (PDESİ) inhibitörünün (Tadalafil 5 mg) günlük kullanımı ile kombine edilen düşük dansiteli lineer şok dalga tedavisini (LI-ESWT), sadece PDESİ'nin günlük kullanımı ile kıyaslayarak LI-ESWT'nin etkinliğini değerlendirmektir. Gereç ve Yöntem: Toplam 23 hasta çalışmaya dahil edildi. Bu hastalar LI-ESWT + tadalafil 5 mg tedavisi (n=10) uygulanan, sadece tadalafil 5 mg tedavisi uygulanan (n=13) hastalar şeklinde iki gruba ayrıldı. LI-ESWT, 4 hafta boyunca haftada bir kez uygulandı. Her iki gruptaki hastalara da There are studies showing that low-intensity linear shockwave treatment (LI-ESWT) was effective and successful in erectile dysfunction (ED) due to vascular disorders, especially in arteriogenic ED. It has been claimed that LI-ESWT caused neovascularization by stimulating angiogenesis and increased endothelial cell proliferation. The efficacy of LI-ESWT + phosphodiesterase type 5 inhibitors (PDE5i) was compared with PDE5i treatment only in patients with severe ED who were diagnosed with penile arteriogenic ED based on penile Doppler ultrasonography.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of Low Density Linear Shockwave Treatment in Severe Arteriogenic Erectile Dysfunction Patients

Sönmez¹,

Kara²

2017

jus

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A systematic review of the long-term efficacy of low-intensity shockwave therapy for vasculogenic erectile dysfunction

et al. 2019

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Purpose To look at the evidence base for LISWT as a treatment modality for vasculogenic erectile dysfunction, focusing on the long-term outcomes at over 6 months following treatment. Methods A systematic literature search was conducted utilising MEDLINE and Scopus databases from 2010 to September 2018 by two independent reviewers. Outcome measures extracted for long-term efficacy included International Index of Erectile Function scores and Erection Hardness Scores. Subgroup analysis for LISWT effectiveness included age, PDE5i responsiveness, presence of vascular co-morbidities and smoking status. Results The search identified eleven studies, representing a total of 799 patients. Nine studies found a significant improvement in erectile function after LISWT at 6-month follow-up (median IIEF-EF improvement in 5.3 at 6 months). However, of five studies assessing erectile function at 12 months; two identified a plateauing of results, with three a deterioration (IIEF-EF score changes of − 2 to 0.1 from 6 months). Erectile function did, however, remain above baseline results in all of these studies. Subgroup analysis revealed increasing age to reduce the response to LISWT treatment. Whilst ED severity, PDE5i responsiveness and co-morbidities potentially influence effectiveness, results are still inconsistent. Conclusions LISWT may be a safe and acceptable potential ED treatment with demonstrated benefits at 6 months. There is some question regarding efficacy deterioration beyond this, but there is still a demonstrated benefit seen even at 12 months post treatment. However, quality of evidence remains low with larger multiinstitutional studies required, standardising confounders such as shockwave administration and oral medication use. Electronic supplementary material The online version of this article (10.1007/s11255-019-02127-z) contains supplementary material, which is available to authorized users.

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Acupuncture for erectile dysfunction: Insights and future research directions

Simões,

Rodrigues

2023

Revista Internacional de Acupuntura

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Linear shock wave therapy in the treatment of erectile dysfunction

Cited by 20 publications

References 10 publications

Efficacy of Low Density Linear Shockwave Treatment in Severe Arteriogenic Erectile Dysfunction Patients

Efficacy of Low Density Linear Shockwave Treatment in Severe Arteriogenic Erectile Dysfunction Patients

A systematic review of the long-term efficacy of low-intensity shockwave therapy for vasculogenic erectile dysfunction

Acupuncture for erectile dysfunction: Insights and future research directions

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