Linear streaking after bleomycin administration

Vignini, M.; Miori, L.; Brusamolino, Ercole; Pelfini, C.

doi:10.1111/j.1365-2230.1989.tb00950.x

Cited by 11 publications

(8 citation statements)

References 1 publication

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“…To date a number of cases with bleomycin‐induced flagellate erythema have been reported 10–28 . Additionally, an unusual case of reticular and linear hyperpigmentation has been reported 29 .…”

Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

“…It is considered that the reaction is dose‐dependent and usually occurs in total doses > 100 U and often > 200 U. In contrast, it can occur after small doses as low as 14–15 U 16–18,21,28 . The duration between administration of bleomycin and the onset of the clinical symptoms varies from 12–24 h 11,16,17,19 to 6 months 27 .…”

Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

“…In contrast, it can occur after small doses as low as 14–15 U 16–18,21,28 . The duration between administration of bleomycin and the onset of the clinical symptoms varies from 12–24 h 11,16,17,19 to 6 months 27 . Some patients complain of generalized pruritus immediately after the bleomycin administration, which eventually develops to the typical flagellate erythema.…”

Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

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Flagellate erythema

Yamamoto¹,

Nishioka²

2005

Int J Dermatology

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Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

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Flagellate erythema

Yamamoto¹,

Nishioka²

2005

Int J Dermatology

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“…The linear or streaked pigmentation usually develops after a cumulative dose between 100-300 U of bleomycin (6,17), whereas considering our cases the cumulative doses were 38 U and 30 U. There are only 17 adult cases of FH following treatment with low-dose bleomycin (Table 1) (2,4,6,8,9,14,15,(17)(18)(19)(20)(21)(22)(25)(26)(27). It is observed that the majority of patients developing FH within 7 days of administration of bleomycin were young adults, even the dose of bleomycin was between 5-30 U.…”

Section: Discussionmentioning

confidence: 99%

Flagellate Hyperpigmentation Following Treatment with Low-Dose Bleomycine: Report of two cases

Cokmert¹,

Demir²,

Akyol³

2015

Acta Oncol Tur.

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ÖZETBleomisin'in mukokutanöz yan etkileri, 100 U'den daha yüksek kümülatif dozları alan hastalarda yaygındır. Flagella benzeri hiperpigmentasyon bleomisin kullanımının neden olduğu, vakaların yaklaşık % 8-20'sinde görülen ilginç bir cilt reaksiyonudur. Mekanizması bilinmemektedir. Tanı karakteristik klinik görünüme dayanmaktadır. Hiperpigmente cilt lezyonlarının histolojik incelemesi, bazal keratinositlerde artmış melanin içeriğini ortaya koymaktadır. Hafif vakalar antihistaminiklere ve/veya sistemik steroide yanıt verir fakat birçok vakada ilacın kesilmesi gerekebilir. Biz rölatif olarak daha düşük (kümülatif dozlar 30 ve 38 U) dozlarla bleomisin kaynaklı flagella benzeri hiperpigmentasyonu olan 2 vaka sunuyoruz. Bleomisin kullanan hastalarda hiç de nadir olmayan bu komplikasyonu klinisyenler akılda bulundurmalıdırlar. Anahtar Kelimeler: Hiperpigmentasyon, Bileomisin, Cilt ABSTRACT Mucocutaneus side effects of bleomycin therapy are common in patients receiving cumulative doses greater than 100 U (100 mg). Flagellate hyperpigmentation is an interesting cutaneus reaction caused by bleomycin use, and is seen in about 8-20% of cases. The mechanism is unknown. Diagnosis is based on its characteristic clinical appearance. Histological examination of hyperpigmented skin lesions has demonstrated increased melanin content in basal keratinocytes. It has been suggested that mild cases may respond to antihistamines and ⁄ or systemic steroids, but in many cases discontinuation of the drug may be necessary. We present two patients (cumulative doses of 30 and 38 U) that developed bleomycin-induced flagellate hyperpigmentation with relatively low doses. Because the condition is not uncommon in patients who are using this drug, the clinician should be mindful of this complication.

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“…The reaction is considered to be dose dependent and normally occurs at total doses > 100 U and very frequently at doses > 200 U. By contrast, it can also occur after small doses as low as 14–15 U 39,46–48,51 . The duration between administration of bleomycin and the onset of the clinical symptoms varies from 12–24 h 41,46,47,49 to 6 months 57 .…”

Section: ‘Flagellate’ Erythemamentioning

confidence: 99%

Bleomycin and the skin

Yamamoto

2006

British Journal of Dermatology

122

111

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Bleomycin is frequently used as a chemotherapeutic agent to treat various kinds of malignancy. However, the cytotoxic effects of bleomycin cause a number of adverse responses, in particular in the lung and the skin. Bleomycin is used by dermatologists as a treatment for various skin cancers, recalcitrant warts, keloid and hypertrophic scars. This article discusses the use of bleomycin for various skin disorders, as well as the risk factors and cutaneous side-effects resulting from its use.

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Linear streaking after bleomycin administration

Cited by 11 publications

References 1 publication

Flagellate erythema

Flagellate erythema

Flagellate Hyperpigmentation Following Treatment with Low-Dose Bleomycine: Report of two cases

Bleomycin and the skin

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