LINEARIZING CONTROL OF YEAST AND BACTERIA FED-BATCH CULTURES - A Comparison of Adaptive and Robust Strategies

Abstract

Linearizing control is a popular approach to control bioprocesses, which has received considerable attention is the past several years. This control approach is however quite sensitive to modeling uncertainties, thus requiring some on-line parametric adaptation so as to ensure performance. In this study, this usual adaptive strategy is compared in terms of implementation and performance to a robust strategy, where the controller has a fixed parametrization which is determined using a LMI framework so as to ensure robust stability and performance. Fed-batch cultures of yeast and bacteria are considered as application examples.