Linggui Zhugan Decoction activates the SIRT1-AMPK-PGC1α signaling pathway to improve mitochondrial and oxidative damage in rats with chronic heart failure caused by myocardial infarction

Yu, Siyi; Qian, Hang; Tian, Dawei; Yang, M.; Li, Dongfeng; Xu, Hao; Chen, Jishun; Yang, Jiamin; Hao, Xincai; Liu, Zhixin; Zhong, Jixin; Yang, Handong; Chen, Xinlong; Min, Xinwen

doi:10.3389/fphar.2023.1074837

Cited by 17 publications

(3 citation statements)

References 51 publications

(54 reference statements)

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“…Chen et al ( 98 ) established a CHF model of cardiac hypertrophy induced by AAS and found that Qishenyiqi dropping pills (QSYQ) can significantly inhibit the progression of cardiac hypertrophy to HF induced by AAS in rats; its mechanism is related to the improvement of energy metabolism, oxidative stress, apoptosis, and other pathways. Lingguizhugan decoction can affect the SIRT1-AMPK-PGC-1α pathway, restore mitochondrial membrane potential, reduce ROS and malondialdehyde (MDA) levels, alleviate mitochondria and oxidative stress damage, promote mitochondrial biogenesis, increase the ejection fraction, and improve cardiac function in rats with HF ( 99 ). At the same time, it also antagonizes oxidative stress damage through the Nrf2/Keap1/HO-1 pathway ( 100 ).…”

Section: The Mechanism Of Tcm In Treating Refractory Heart Failurementioning

confidence: 99%

Clinical evidence and potential mechanisms of traditional Chinese medicine for refractory heart failure: a literature review and perspectives

Guo,

Yang,

Feng

et al. 2024

Front. Cardiovasc. Med.

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Refractory heart failure (RHF), or end-stage heart failure, has a poor prognosis and high case fatality rate, making it one of the therapeutic difficulties in the cardiovascular field. Despite the continuous abundance of methods and means for treating RHF in modern medicine, it still cannot meet the clinical needs of patients with RHF. How to further reduce the mortality rate and readmission rate of patients with RHF and improve their quality of life is still a difficult point in current research. In China, traditional Chinese medicine (TCM) has been widely used and has accumulated rich experience in the treatment of RHF due to its unique efficacy and safety advantages. Based on this, we comprehensively summarized and analyzed the clinical evidence and mechanism of action of TCM in the treatment of RHF and proposed urgent scientific issues and future research strategies for the treatment of RHF with TCM, to provide reference for the treatment of RHF.

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Section: The Mechanism Of Tcm In Treating Refractory Heart Failurementioning

confidence: 99%

Clinical evidence and potential mechanisms of traditional Chinese medicine for refractory heart failure: a literature review and perspectives

Guo,

Yang,

Feng

et al. 2024

Front. Cardiovasc. Med.

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“…Their findings demonstrated that lncRNA SNHG8 not only emerged as a risk factor for MI but also exhibited substantial diagnostic potential. Furthermore, extensive transcriptomic studies have revealed a significant correlation between the abnormal expression of inflammation-related genes, such as VEGFA ( 102 ), TNF ( 103 ), IL6 ( 103 , 104 ), IL6R ( 104 ), PTGS2 ( 105 ), immune response-related genes including CDKN2B ( 106 ), CDKN1C ( 107 ), TLR2 ( 108 ), TLR4 ( 108 ), apoptosis and proliferation-related genes like F3 ( 109 ), BTG2 ( 110 ), TXNIP ( 111 ), SAMSN1 ( 112 ), lipid metabolism-related genes such as PPARGC1A ( 113 ), ACSL1 ( 114 ), ABCG1 ( 115 ), SULT2B1 ( 116 ), and extracellular matrix (ECM) and collagen-related genes, such as MMP2 ( 117 ), MMP9 ( 117 ), LTBP4 ( 118 ), TNXB ( 118 ), and the occurrence and development of MI. These findings offer crucial insights into a deeper comprehension of the mechanisms underlying MI and hold promise for the development of more precise approaches for preventing and treating heart disease in the future.…”

Section: Single-omics Approachesmentioning

confidence: 99%

From multi-omics approaches to personalized medicine in myocardial infarction

Zhan,

Tang,

et al. 2023

Front. Cardiovasc. Med.

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Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe complications such as arrhythmia, cardiac rupture, heart failure, and sudden death. Despite being a research hotspot, the etiological mechanism of MI remains unclear. The emergence and widespread use of omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and other omics, have provided new opportunities for exploring the molecular mechanism of MI and identifying a large number of disease biomarkers. However, a single-omics approach has limitations in understanding the complex biological pathways of diseases. The multi-omics approach can reveal the interaction network among molecules at various levels and overcome the limitations of the single-omics approaches. This review focuses on the omics studies of MI, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and other omics. The exploration extended into the domain of multi-omics integrative analysis, accompanied by a compilation of diverse online resources, databases, and tools conducive to these investigations. Additionally, we discussed the role and prospects of multi-omics approaches in personalized medicine, highlighting the potential for improving diagnosis, treatment, and prognosis of MI.

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“…17,18 Numerous pharmacological studies have shown that Chinese medicines have the advantages of good safety and precise efficacy in the prevention and treatment of HF, and the AMPK signalling pathway is one of the key pathways through which the active ingredients of Chinese medicines and Chinese medicinal extracts can play a role in improving the outcomes in HF. [19][20][21] This article will review the existing pharmacological and experimental research results of TCM intervention in AMPK signalling pathway to improve HF in recent years.…”

Section: Introductionmentioning

confidence: 99%

AMPK Signalling Pathway: A Potential Strategy for the Treatment of Heart Failure with Chinese Medicine

Liu,

Guo,

Zhou

et al. 2023

JIR

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Heart failure (HF) is a complex clinical syndrome that represents the advanced stage of cardiovascular disease, characterized by systolic and diastolic dysfunction of the heart. Despite continuous updates in HF treatment drugs, the morbidity and mortality rates remain high, necessitating ongoing exploration for new therapeutic targets. Adenosine monophosphate-activated protein kinase (AMPK) is the serine/ threonine protein kinase which responds to adenosine monophosphate (AMP) levels.Activation of AMPK shifts cellular metabolic patterns from synthesis to catabolism, enhancing energy metabolism in pathological conditions such as inflammation, ischemia, obesity, and aging. Numerous studies have identified AMPK as a vital target for HF treatment, with herbal monomers/extracts and compounds affecting key signaling factors including rapamycin targeting protein (mTOR), silencing regulator protein 1 (SIRT1), nuclear transcription factor E2-related factor 2 (Nrf2), and nuclear transcription factor-κB (NF-κB) through regulation of the AMPK signaling pathway.This modulation can achieve the effects of improving metabolism, autophagy, reducing oxidative stress and inflammatory response in the treatment of heart failure, with the advantages of multi-targeting, comprehensive action and low toxicity.The modulation of the AMPK pathway by Traditional Chinese Medicine (TCM) has emerged as a crucial research direction for the prevention and treatment of HF, but a systematic summary and generalization in this field is lacking. This article provides an overview of the composition, regulation, and mechanism of the AMPK signaling pathway's influence on HF, as well as a summary of current research on the regulation of the AMPK pathway by TCM for HF prevention and treatment. The aim is to serve as a reference for the diagnosis and treatment of HF using TCM and the development of new drugs.

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Linggui Zhugan Decoction activates the SIRT1-AMPK-PGC1α signaling pathway to improve mitochondrial and oxidative damage in rats with chronic heart failure caused by myocardial infarction

Cited by 17 publications

References 51 publications

Clinical evidence and potential mechanisms of traditional Chinese medicine for refractory heart failure: a literature review and perspectives

Clinical evidence and potential mechanisms of traditional Chinese medicine for refractory heart failure: a literature review and perspectives

From multi-omics approaches to personalized medicine in myocardial infarction

AMPK Signalling Pathway: A Potential Strategy for the Treatment of Heart Failure with Chinese Medicine

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