Link between COVID-19 vaccines and myocardial infarction

Zafar, Umema; Zafar, Hamna; Ahmed, Mian Saad; Khattak, Madiha

doi:10.12998/wjcc.v10.i28.10109

Cited by 13 publications

(10 citation statements)

References 42 publications

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“…Some studies have observed distinctive characteristics among cases, such as older patients more frequently experiencing onset after the first dose of viral vector vaccines. This, as stated by Zafar et al, 27 suggests that the immune response may play a smaller role in vaccine-induced MI than in myocarditis. Instead, it is more plausible to include a demand-supply mismatch in the explanation, especially among elderly patients or those with comorbidities who are more susceptible to the stress of vaccination.…”

Section: Myocardial Infarction (Mi) and Vaccinesmentioning

confidence: 69%

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Benefits and Harms of COVID-19 Vaccines in Cardiovascular Disease: A Comprehensive Review

Chen

2023

J Lipid Atheroscler

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Patients with a history of cardiovascular disease (CVD) who contract coronavirus disease 2019 (COVID-19) tend to have a worse prognosis and more severe cardiovascular side effects. COVID-19 vaccines, which are intended to prevent COVID-19, may also potentially reduce the severity and complications (including cardiovascular sequelae) of COVID-19, especially in patients with a history of CVD. However, there have also been reports of cardiovascular side effects from COVID-19 vaccines of various brands and types. The purpose of this study is to review the benefits and harms of COVID-19 vaccines in relation to CVD. In this thorough review of the most current evidence on the benefits and harms of COVID-19 vaccines, we present information about the characteristics of cardiovascular complications. Most of the evidence focuses on myocarditis or pericarditis, which are most strongly associated with mRNA vaccines and predominantly occur in young males within days of receiving the second dose. Meanwhile, post-vaccination myocardial infarction is more common in older males, and the first dose of adenoviral vector vaccines appears to play a greater role in this complication. This information may guide us in formulating alternative options and implementing targeted surveillance. Gaining more knowledge about the potential benefits and harms of COVID-19 vaccines will improve our ability to make informed decisions and judgments about the balance of these factors.

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Section: Myocardial Infarction (Mi) and Vaccinesmentioning

confidence: 69%

“…Instead, it is more plausible to include a demand-supply mismatch in the explanation, especially among elderly patients or those with comorbidities who are more susceptible to the stress of vaccination. 27 However, further studies are still needed to understand this issue comprehensively.…”

Section: Myocardial Infarction (Mi) and Vaccinesmentioning

confidence: 99%

Benefits and Harms of COVID-19 Vaccines in Cardiovascular Disease: A Comprehensive Review

Chen

2023

J Lipid Atheroscler

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“…It has been observed that MI following the administration of COVID-19 vaccination occurred most frequently in males with a mean age of 63.45 years [ 69 ]. Moreover, AstraZeneca vaccinations were associated with a higher incidence of coronary artery disease, particularly STEMI, primarily observed after the initial vaccine dose [ 71 ]. In contrast, a study comparing rates of acute MI after COVID-19 infection and among vaccinated populations demonstrated much higher acute MI rates in the unvaccinated compared to those not vaccinated with COVID-19 vaccine.…”

Section: Reviewmentioning

confidence: 99%

Multifaceted Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on ST-Elevation Myocardial Infarction (STEMI): A Literature Review of Incidence, Treatment Modalities, and Outcomes

Choi,

Maity,

Qureshi

et al. 2024

Cureus

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The global repercussions of coronavirus disease 2019 (COVID-19) include substantial worldwide mortality and have brought to light existing gaps in healthcare systems. Particularly, diseases requiring time-sensitive treatment, such as ST-elevation myocardial infarction (STEMI), have faced significant challenges due to the impact and revelations of the COVID-19 pandemic on healthcare infrastructure. This review addresses the impact of the pandemic on STEMI, exploring incidence, treatment modalities, and clinical outcomes. Through a critical examination of existing literature, the intricate relationship between the pandemic and cardiovascular health, specifically STEMI, is elucidated. The COVID-19 pandemic has had a significant impact on the management of STEMI, with changes in hospitalization rates, treatment strategies, and the presentation of the disease posing significant challenges. The contradictory results of COVID-19 and post-vaccine myocardial infarction, as well as gender differences in reported cases, highlight the need for further research to clarify these relationships.

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“…Generally, AE after vaccination are neither frequent nor serious ( 9 ). However, rare AE such as acute myocardial infarction (AMI) are potentially life-threatening ( 22 , 23 ). Herein, we present a case of an 83-year-old male who suffered allergic reactions developing to AMI ten minutes after the first inactivated COVID-19 vaccination in China.…”

Section: Introductionmentioning

confidence: 99%

Acute myocardial infarction after inactivated COVID-19 vaccination: a case report and literature review

Wang

Zhang

et al. 2023

Front. Cardiovasc. Med.

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A number of vaccines have been developed and deployed globally to restrain the spreading of the coronavirus disease 2019 (COVID-19). The adverse effect following vaccination is an important consideration. Acute myocardial infarction (AMI) is a kind of rare adverse event after COVID-19 vaccination. Herein, we present a case of an 83-year-old male who suffered cold sweat ten minutes after the first inactivated COVID-19 vaccination and AMI one day later. The emergency coronary angiography showed coronary thrombosis and underlying stenosis in his coronary artery. Type II Kounis syndrome might be a potential mechanism, which is manifested as coronary thrombosis secondary to allergic reactions in patients with underlying asymptomatic coronary heart disease. We also summarize the reported AMI cases post COVID-19 vaccination, as well as overview and discuss the proposed mechanisms of AMI after COVID-19 vaccination, thus providing insights for clinicians to be aware of the possibility of AMI following COVID-19 vaccination and potential underlying mechanisms.

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Link between COVID-19 vaccines and myocardial infarction

Cited by 13 publications

References 42 publications

Benefits and Harms of COVID-19 Vaccines in Cardiovascular Disease: A Comprehensive Review

Benefits and Harms of COVID-19 Vaccines in Cardiovascular Disease: A Comprehensive Review

Multifaceted Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on ST-Elevation Myocardial Infarction (STEMI): A Literature Review of Incidence, Treatment Modalities, and Outcomes

Acute myocardial infarction after inactivated COVID-19 vaccination: a case report and literature review

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