Linkage and QTL mapping for Sus scrofa chromosome 1

Abstract

Summary Linkage maps of Sus scrofa chromosome 1 (SSC1) have been produced using 10 markers in three different F2 families based on crosses of Meishan (M), Pietrain (P) and Wild Boar (W). The maps were similar for the different families and show higher paternal recombination, especially in the interval SW2130–SW803. Quantitative trait loci (QTLs) affecting body conformation, carcass composition, fat deposition and numbers of teats were identified in all three families. Major QTLs were mapped in chromosomal intervals centred at approximately 60, 120 and 170 cM. The QTLs explain up to 8.4% of phenotypic variance in the F2 generation. Pietrain QTL alleles were superior in comparison with Wild Boar and Meishan alleles for most of the trait values. Meishan alleles were associated with highest fat deposition. Additive gene effects were generally larger than dominance effects. QTL profiles on SSC1 differed between families, with the W × P family being most distinct.

Factor analysis applied to genome prediction for high-dimensional phenotypes in pigs

“…Chromosome 1 also presented a higher importance for the ETUL, ETL, and ETO traits, similar to results found by Beeckmann et al (2003), Rohrer and Keele (1998), and Azevedo et al (2013b).…”

Polymorphism of the porcine CGA gene and its association with growth and carcass traits

“…This suggested that only SNP C-925T, which locates in the promoter region, may be the candidate causative SNP or in linkage at a high r 2 with the causative SNP which is responsible for these traits' variations. Our results confirmed the existence of QTLs adjacent to the CGA region for carcass composition, growth rate and backfat thickness which have been reported previously (Malek et al, 2001;Beeckmann et al, 2003;Liu et al, 2007). Variations in the promoter region of CGA gene, but not the other gene components might be the candidates for these QTLs and further investigation is worthwhile.…”

“…A QTL for ham external fat weight on SSC1 in the European wild boar and Pietrain resource family has been reported by Beeckmann et al (2003), and the CGA SNP A+15599G could be in linkage with the causative SNP for this QTL. Interestingly, haplotype block 1 also showed significant association with ham external fat weight, but combining the haplotype block 1 and SNP A+15599G decreased the association possibility.…”

“…Considering the extensive effects of the glycoprotein hormones, especially TSH, their common CGA gene shows to be a promising candidate gene for economic important traits. However, comparing with the large number of Quantitative trait loci (QTL) that have been mapped on SSC 1, there are only a limited number of QTL adjacent to the CGA gene, and they have only been reported in some studies (Malek et al, 2001;Beeckmann et al, 2003;Evans et al, 2003;Liu et al, 2007) and were undetectable in others (Rohrer & Keele, 1998;Bidanel et al, 2001;De Koning et al, 2001;Beeckmann et al, 2003;Rohrer et al, 2006;Liu et al, 2007;Edwards et al, 2008).…”

Cloning of Perilipin 2 Gene and Investigating its Expression Level in Porcine Longissimus Muscle

“…PLIN2 plays a role in protecting the neutral lipid stores from the activity of cytosolic lipases [24], and therefore in regulating lipid storage, in particular in non-adipose tissues. In fact, in adipose tissue PLIN2 is gradually replaced by PLIN1 during adipocyte maturation, whereas in other tissues, as skeletal muscle, PLIN2 remains the main lipid droplet associated protein [15]. Swiss-Model is classical online modeling software, and widely used for modeling unknown protein sequence by homology.…”