Linking Artificial Light at Night with Human Health via a Multi-Component Framework: A Systematic Evidence Map

Liu, Yang; Yu, Changda; Wang, Keli; Kwan, Mei‐Po; Tse, Lap Ah

doi:10.3390/environments10030039

Cited by 7 publications

(16 citation statements)

References 180 publications

(215 reference statements)

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“…Hormone secretions, including melatonin, follow the circadian rhythm and play a significant role in modulating immune system activity . ALAN has been shown to inhibit melatonin secretion, leading to impaired immune function.…”

Section: Discussionmentioning

confidence: 99%

“…Circadian rhythms are central to the health effects of ALAN . In vertebrates, phagocytosis of the photoreceptor’s outer segments is synchronized by circadian rhythms .…”

Section: Discussionmentioning

confidence: 99%

“…Circadian rhythms are central to the health effects of ALAN. 24 In vertebrates, phagocytosis of the photoreceptor’s outer segments is synchronized by circadian rhythms. 53 Impairment in the timely clearance of a phagocytosed photoreceptor’s outer segments can lead to cumulative oxidative damage in the RPE.…”

Section: Discussionmentioning

confidence: 99%

“…The potential detrimental health impacts of light pollution have expanded beyond sleep disorders to include obesity, cardiovascular diseases, cancers, and mental disorders . The primary mechanism through which these effects occur is believed to be the disruption of circadian rhythms and subsequent impaired hormone secretion, particularly those associated with sleep disturbances …”

Section: Introductionmentioning

confidence: 99%

“… 22 , 23 The primary mechanism through which these effects occur is believed to be the disruption of circadian rhythms and subsequent impaired hormone secretion, particularly those associated with sleep disturbances. 24 …”

Section: Introductionmentioning

confidence: 99%

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Nighttime Outdoor Artificial Light and Risk of Age-Related Macular Degeneration

Kim,

Shin

et al. 2024

JAMA Netw Open

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ImportanceLight pollution’s impact on human health is increasingly recognized, but its link to exudative age-related macular degeneration (EAMD) remains unclear.ObjectiveTo investigate the association between exposure to outdoor artificial light at night (OALAN) and the risk of incident EAMD.Design, Setting, and ParticipantsIn this nationwide population-based case-control study, all individuals 50 years or older with newly diagnosed EAMD between January 1, 2010, and December 31, 2011, were identified with reference to the Korean National Health Insurance Service registration program database for rare and intractable diseases. Birth year– and sex-matched controls (with no EAMD diagnosis until 2020) were selected at a 1:30 ratio. Data were acquired from May 1 to December 31, 2021, and analyzed from June 1 to November 30, 2022.ExposuresMean levels of OALAN at participants’ residential addresses during 2008 and 2009 were estimated using time-varying satellite data for a composite view of persistent nighttime illumination at an approximate scale of 1 km2.Main Outcomes and MeasuresThe hazard ratios (HRs) and 95% CIs of the association between residential OALAN and risk of incident EAMD were determined based on maximum likelihood estimation after adjusting for sociodemographic characteristics, comorbidities, and area-level risk factors (ie, nighttime traffic noise and particulate matter of aerodynamic diameter ≤10 μm in each participant’s administrative district of residence).ResultsA total of 126 418 participants were included in the analysis (mean [SD] age, 66.0 [7.9] years; 78 244 men [61.9%]). Of these, 4078 were patients with newly diagnosed EAMD and 122 340 were EAMD-free matched controls. In fully adjusted models, an IQR (55.8 nW/cm2/sr) increase in OALAN level was associated with an HR of 1.67 (95% CI, 1.56-1.78) for incident EAMD. The exposure-response curve demonstrated a nonlinear, concave upward slope becoming more pronounced at higher levels of light exposure (ie, at approximately 110 nW/cm2/sr). In a subgroup analysis, an IQR increase in OALAN was associated with increased risk of incident EAMD in urban areas (HR, 1.46 [95% CI, 1.33-1.61]) but not in rural areas (HR, 1.01 [95% CI, 0.84-1.22]).Conclusions and RelevanceIn this nationwide population-based case-control study, higher levels of residential OALAN were associated with an increased risk of incident EAMD. Future studies with more detailed information on exposure, individual adaptive behaviors, and potential mediators are warranted.

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Section: Discussionmentioning

confidence: 99%

“…Circadian rhythms are central to the health effects of ALAN . In vertebrates, phagocytosis of the photoreceptor’s outer segments is synchronized by circadian rhythms .…”

Section: Discussionmentioning

confidence: 99%