2023
DOI: 10.3389/fphys.2023.1095260
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Linking cortex and contraction—Integrating models along the corticomuscular pathway

Abstract: Computational models of the neuromusculoskeletal system provide a deterministic approach to investigate input-output relationships in the human motor system. Neuromusculoskeletal models are typically used to estimate muscle activations and forces that are consistent with observed motion under healthy and pathological conditions. However, many movement pathologies originate in the brain, including stroke, cerebral palsy, and Parkinson’s disease, while most neuromusculoskeletal models deal exclusively with the p… Show more

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Cited by 5 publications
(3 citation statements)
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References 279 publications
(465 reference statements)
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“…Input structures such as premotor cortex and basal ganglia to drive cortical activity will also be necessary ( Logiaco, Abbott, & Escola, 2021 ). To further investigate the functionality of the cortex using this model, it could be placed within a larger scale framework of motor generation to connect input, motor cortical activity and resulting muscle force generation ( Haggie et al, 2023b ).…”
Section: Discussionmentioning
confidence: 99%
“…Input structures such as premotor cortex and basal ganglia to drive cortical activity will also be necessary ( Logiaco, Abbott, & Escola, 2021 ). To further investigate the functionality of the cortex using this model, it could be placed within a larger scale framework of motor generation to connect input, motor cortical activity and resulting muscle force generation ( Haggie et al, 2023b ).…”
Section: Discussionmentioning
confidence: 99%
“…The FitzHugh-Nagumo model was also assessed for having only two equations; however, its representation is less faithful than that of the Hodgkin-Huxley model [42]. Moreover, many recent studies were based on the formalism of the Hodgkin-Huxley model, while many others employ an even simpler formulation based on a transfer function, as indicated in [43]. As shown in [37], the stimulus is responsible for changing the rates k 1 and k 2 .…”
Section: Action Potential Modelmentioning
confidence: 99%
“…Surface electromyography (EMG) signals have been widely used for assessing different aspects of neuromuscular function [ 1 4 ], as well as for diagnosing neurological disorders [ 5 , 6 ]. Large-scale neuromusculoskeletal computational models also use surface EMG signals for predicting neuromuscular responses, which may not be directly assessed through experiments with human subjects [ 7 11 ]. Specifically, surface EMG signals are simulated as an output to computational neural models, which reproduce motor control mechanisms of experimental conditions [ 8 , 12 15 ].…”
Section: Introductionmentioning
confidence: 99%