Linking microbial diversity and population dynamics to the removal efficiency of pharmaceutically active compounds (PhACs) in an anaerobic/anoxic/aerobic (A2O) system

Gallardo-Altamirano, M.J.; Maza-Márquez, Paula; Montemurro, Nicola; Rodelas, B.; Osorio, Francisco; Pozo, Clementina

doi:10.1016/j.chemosphere.2019.06.017

Cited by 31 publications

(12 citation statements)

References 81 publications

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“…This may be one of the reasons why the order of SREs was different in individual treatment processes. For instance, Gallardo-Altamirano et al (2019) compared removal efficiencies of 19 pharmaceuticals under two experimental phases (different MLSS concentration and F/M ratio), reporting that the removal efficiencies of some pharmaceuticals such as clarithromycin, gemfibrozil, and atenolol increased twofold at high MLSS concentration and low F/M ratio [58]. The degree of microbial diversity and pharmaceutical removal are influenced by operational parameters, such as SRT, redox condition, and carbon supply [57,59].…”

Section: Removal Of Pharmaceuticals By Biological Treatment Processesmentioning

confidence: 99%

Distribution and Removal of Pharmaceuticals in Liquid and Solid Phases in the Unit Processes of Sewage Treatment Plants

Park

Kim

Hong³

et al. 2020

IJERPH

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In this study, we analyzed 27 pharmaceuticals in liquid and solid phase samples collected from the unit processes of four different sewage treatment plants (STPs) to evaluate their distribution and behavior of the pharmaceuticals. The examination of the relative distributions of various categories of pharmaceuticals in the influent showed that non-steroidal anti-inflammatory drugs (NSAIDs) were the most dominant. While the relative distribution of antibiotics in the influent was not high (i.e., 3%–5%), it increased to 14%–30% in the effluent. In the four STPs, the mass load of the target pharmaceuticals was reduced by 88%–95% mainly in the biological treatment process, whereas the ratio of pharmaceuticals in waste sludge to those in the influent (w/w) was only 2%. In all the STPs, the removal efficiencies for the stimulant caffeine, NSAIDs (acetaminophen, naproxen, and acetylsalicylic acid), and the antibiotic cefradine were high; they were removed mainly by biological processes. Certain compounds, such as the NSAID ketoprofen, contrast agent iopromide, lipid regulator gemfibrozil, and antibiotic sulfamethoxazole, showed varying removal efficiencies depending on the contribution of biodegradation and sludge sorption. In addition, a quantitative meta-analysis was performed to compare the pharmaceutical removal efficiencies of the biological treatment processes in the four STPs, which were a membrane bioreactor (MBR) process, sequencing batch reactor (SBR) process, anaerobic–anoxic–oxic (A2O) process, and moving-bed biofilm reactor (MBBR) process. Among the biological processes, the removal efficiency was in the order of MBR > SBR > A2O > MBBR. Among the tertiary treatment processes investigated, powdered activated carbon showed the highest removal efficiency of 18%–63% for gemfibrozil, ibuprofen, ketoprofen, atenolol, cimetidine, and trimethoprim.

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Section: Removal Of Pharmaceuticals By Biological Treatment Processesmentioning

confidence: 99%

Distribution and Removal of Pharmaceuticals in Liquid and Solid Phases in the Unit Processes of Sewage Treatment Plants

Park

Kim

Hong³

et al. 2020

IJERPH

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“…Gallardo‐Altamirano et al (2019) studied that nineteen pharmaceutically active compounds (PhACs) affected on microbial diversity in activated sludge of anaerobic–anoxic–aerobic (A2O) system. The results indicated that food‐to‐microorganisms ratio (F/M) and mixed liquor suspended solids (MLSS) were significant indexes for PhACs removal and the migration of activated sludge community was strongly associated with the removal efficiency of PhACs.…”

Section: Process Microbiology Of Activated Sludgementioning

confidence: 99%

Activated sludge and other aerobic suspended culture processes

Ouyang

et al. 2020

Water Environment Research

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This paper provides an overview of activated sludge related to suspended growth processes for the year 2019. The review encompasses process modeling of activated sludge, microbiology of activated sludge, process kinetics and mechanism, nitrogen and phosphorus control, design, and operation in the activated sludge field. The fate and effect of xenobiotics in activated sludge, including trace organic contaminant and heavy metal xenobiotics, which had influence on the growth of suspended sludge, are covered in this review. Compared to past reviews, many topics show increase in activity in 2019. These include, biokinetics process of aerobic granular sludge formation, pyrolysis kinetic mechanism of granular sludge. These topics are referred to formation and disintegration of granular sludge. Other sections include activated sludge settling model, toxicity resistant microbial community, nitritation-anammox processes for nitrogen removal, and respirometry used in the operation of real wastewater treatment plant are especially highlighted in this review.

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“…For example, Trametes versicolor was shown to remove a plethora of micropollutants, inducing naproxen, carbamazepine, and ibuprofen (14,17). By comparison, the corresponding capacity of ascomycetes remains underexplored, despite their dominance in WWTPs (18)(19)(20). Mainly, Aspergillus(21) and Penicillium oxalicum (22) have been demonstrated to remove micropollutants.…”

Section: Introductionmentioning

confidence: 99%

Cladosporiumspecies detoxify multiple water micropollutants of emerging concern using diverse strategies

Leth,

Tang,

Sørensen

et al. 2023

Preprint

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The accumulation of micropollutants of emerging concern in aqueous systems raises safety concerns regarding biological systems and human health. Mycoremediation is a promising and green strategy to mitigate the micropollutant challenge. Hitherto, focus has mainly been on white-rot Basidiomycota and micropollutant transformation by ascomycetes remains underexplored. Here, we assayed 53 Ascomycota isolates from 10 genera for the removal of 22 micropollutants. Notably, 9 out of 22 micropollutants were removed from fungal culture supernatant at efficacies >45%. Temporal analysis of the nine top- performing strains, highlighted remarkable potency ofCladosporiumisolates in removal of multiple micropollutants. Importantly,Cladosporiumconsiderably reduced the toxicity of a micropollutant cocktail based on growth assays. Metabolomics analyses identified oxidation for 5-methyl-1H-benzotriazole and citalopram, whereas methylation and carboxylation were observed for 5-chlorobenzotriazole. No transformation products were detected for ciprofloxacin, sulfamethoxazole, and sertraline, hinting their extensive degradation. These findings suggest micropollutant transformation via diverse catalytic routes byCladosporium. Genome sequencing and proteomic analyses of the top-performing isolates were consistent with the observed transformations and tentatively identified the molecular apparatus, conferring micropollutant transformation. This unprecedented study brings novel insight into the micropollutant transformation and detoxification capabilities of the prevalentCladosporiumspecies, thereby revealing a considerable and hitherto underappreciated potential of this genus and potentially other ascomycetes in micropollutant transformation.ImportanceAt present, conventional wastewater treatment plants (WWTPs) are not designed for removing micropollutants, which are released into aqueous systems. This raises concerns due to the poor insight into micropollutant long-term interplay with biological systems. Innovating biotechnological solutions to tackle micropollutant require addressing the paucity of knowledge on microbial groups and molecular pathways, which mediate micropollutant transformation. Our study highlights the considerable potential of theCladosporiumgenus that remains underexplored in the arena of micropollutant transformation. We report the first genomes sequences for threeCladosporiumspecies:C. allicinum, C. inversicolor,andC. fusiforme, which sets the stage for further analyses of micropollutant transformation, but also offers an important resource on this ecologically significant, albeit under-studied genus and related Ascomycota.

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Linking microbial diversity and population dynamics to the removal efficiency of pharmaceutically active compounds (PhACs) in an anaerobic/anoxic/aerobic (A2O) system

Cited by 31 publications

References 81 publications

Distribution and Removal of Pharmaceuticals in Liquid and Solid Phases in the Unit Processes of Sewage Treatment Plants

Distribution and Removal of Pharmaceuticals in Liquid and Solid Phases in the Unit Processes of Sewage Treatment Plants

Activated sludge and other aerobic suspended culture processes

Cladosporiumspecies detoxify multiple water micropollutants of emerging concern using diverse strategies

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