Lipase Maturation Factor 1 (Lmf1) Is Induced by Endoplasmic Reticulum Stress Through Activating Transcription Factor 6α (Atf6α) Signaling

Mao, Hui Z.; Ehrhardt, Nicole; Bedoya, Candy; Gomez, Javier A.; DeZwaan-McCabe, Diane; Mungrue, Imran N.; Kaufman, Randal J.; Rutkowski, D. Thomas; Péterfy, Miklós

doi:10.1074/jbc.m114.588764

Cited by 13 publications

(4 citation statements)

References 51 publications

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“…Endoplasmic reticulum is the main storage site of Ca 2+ , and any disruption in its accumulation can also promote ER stress. Studies of the relationship between calcium homeostasis and UPR activation using molecules that modify Ca 2+ storage, such as thapsigargin and tunicamycin, reveal that interference with the cation homeostasis induces the UPR response . Calcium concentrations are controlled by three transmembrane channels: Sarco (endo)plasmic reticulum Ca(2+)‐ATPase (SERCA) pumps, responsible for the influx of Ca 2+ from cytosol, ryanodine receptors (RyR), important in skeletal muscle cells, and inositol‐1,4,5‐triphosphate receptor (IP 3 R), both in charge of the cation efflux.…”

Section: The Endoplasmic Reticulum Stressmentioning

confidence: 99%

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

Fernández

Ordóñez

Reíter

et al. 2015

Journal of Pineal Research

434

301

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Endoplasmic reticulum (ER) is a dynamic organelle that participates in a number of cellular functions by controlling lipid metabolism, calcium stores, and proteostasis. Under stressful situations, the ER environment is compromised, and protein maturation is impaired; this causes misfolded proteins to accumulate and a characteristic stress response named unfolded protein response (UPR). UPR protects cells from stress and contributes to cellular homeostasis re-establishment; however, during prolonged ER stress, UPR activation promotes cell death. ER stressors can modulate autophagy which in turn, depending of the situation, induces cell survival or death. Interactions of different autophagy-and apoptosis-related proteins and also common signaling pathways have been found, suggesting an interplay between these cellular processes, although their dynamic features are still unknown. A number of pathologies including metabolic, neurodegenerative and cardiovascular diseases, cancer, inflammation, and viral infections are associated with ER stress, leading to a growing interest in targeting components of the UPR as a therapeutic strategy. Melatonin has a variety of antioxidant, anti-inflammatory, and antitumor effects. As such, it modulates apoptosis and autophagy in cancer cells, neurodegeneration and the development of liver diseases as well as other pathologies. Here, we review the effects of melatonin on the main ER stress mechanisms, focusing on its ability to regulate the autophagic and apoptotic processes. As the number of studies that have analyzed ER stress modulation by this indole remains limited, further research is necessary for a better understanding of the crosstalk between ER stress, autophagy, and apoptosis and to clearly delineate the mechanisms by which melatonin modulates these responses.

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Section: The Endoplasmic Reticulum Stressmentioning

confidence: 99%

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

Fernández

Ordóñez

Reíter

et al. 2015

Journal of Pineal Research

434

301

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“…Specifically, Fam173a encodes a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase ( Małecki et al, 2019 ), and NADH dehydrogenase (ubiquinone) 1 beta subcomplex 10 ( Ndufb10 ) is an accessory subunit of respiratory complex I important for complex assembly ( Friederich et al, 2017 ). Lmf1 (lipase maturation factor 1) is important for regulating plasma lipid levels and responds to redox stress on the endoplasmic reticulum (ER) ( Mao et al, 2014 ). It functions as a molecular chaperone enabling proper folding and activity of ER membrane proteins.…”

Section: Resultsmentioning

confidence: 99%

Positively selected genes in the hoary bat (Lasiurus cinereus) lineage: prominence of thymus expression, immune and metabolic function, and regions of ancient synteny

Cornman¹,

Cryan²

2022

PeerJ

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Background Bats of the genus Lasiurus occur throughout the Americas and have diversified into at least 20 species among three subgenera. The hoary bat (Lasiurus cinereus) is highly migratory and ranges farther across North America than any other wild mammal. Despite the ecological importance of this species as a major insect predator, and the particular susceptibility of lasiurine bats to wind turbine strikes, our understanding of hoary bat ecology, physiology, and behavior remains poor. Methods To better understand adaptive evolution in this lineage, we used whole-genome sequencing to identify protein-coding sequence and explore signatures of positive selection. Gene models were predicted with Maker and compared to seven well-annotated and phylogenetically representative species. Evolutionary rate analysis was performed with PAML. Results Of 9,447 single-copy orthologous groups that met evaluation criteria, 150 genes had a significant excess of nonsynonymous substitutions along the L. cinereus branch (P < 0.001 after manual review of alignments). Selected genes as a group had biased expression, most strongly in thymus tissue. We identified 23 selected genes with reported immune functions as well as a divergent paralog of Steep1 within suborder Yangochiroptera. Seventeen genes had roles in lipid and glucose metabolic pathways, partially overlapping with 15 mitochondrion-associated genes; these adaptations may reflect the metabolic challenges of hibernation, long-distance migration, and seasonal variation in prey abundance. The genomic distribution of positively selected genes differed significantly from background expectation by discrete Kolmogorov–Smirnov test (P < 0.001). Remarkably, the top three physical clusters all coincided with islands of conserved synteny predating Mammalia, the largest of which shares synteny with the human cat-eye critical region (CECR) on 22q11. This observation coupled with the expansion of a novel Tbx1-like gene family may indicate evolutionary innovation during pharyngeal arch development: both the CECR and Tbx1 cause dosage-dependent congenital abnormalities in thymus, heart, and head, and craniodysmorphy is associated with human orthologs of other positively selected genes as well.

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“…When LMF1 expresses an unfolded protein of the response target gene, it is sufficient and necessary to activate the LMF1 promoter through activating transcription factor 6 (Atf6) signaling. Most importantly, induction of LMF1 appears not restricted to lipase-expressing cells but to be a common phenomenon caused by ER stress [ 21 ]. ER stress has a synergistic contribution to EGFR inhibitor gefitinib-induced apoptosis in glioma.…”

Section: Resultsmentioning

confidence: 99%

Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Malignant Neoplasms of the Brain in Taiwan

Lin

Yang

et al. 2022

JPM

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Primary brain malignancy is a rare tumor with a global incidence of less than 10 per 100,000 people. Hence, there is limited power for identifying risk loci in individual studies, especially for Han Chinese. We performed a genome-wide association study (GWAS) in Taiwan, including 195 cases and 195 controls. We identified five new genes for malignant neoplasms of the brain: EDARADD (rs645507, 1p31.3, p = 7.71 × 10−5, odds ratio (OR) = 1.893), RBFOX1 (rs8044700, p = 2.35 × 10−5, OR = 2.36), LMF1 (rs3751667, p = 7.24 × 10−7, OR = 2.17), DPP6 (rs67433368, p = 8.32 × 10−5, OR = 3.94), and NDUFB9 (rs7827791, p = 9.73 × 10−6, OR = 4.42). These data support that genetic susceptibility toward GBM or non-GBM tumors is highly distinct, likely reflecting different etiologies. Combined with signaling analysis, we found that RNA modification may be related to major risk factors in primary malignant neoplasms of the brain.

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Lipase Maturation Factor 1 (Lmf1) Is Induced by Endoplasmic Reticulum Stress Through Activating Transcription Factor 6α (Atf6α) Signaling

Cited by 13 publications

References 51 publications

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

Positively selected genes in the hoary bat (Lasiurus cinereus) lineage: prominence of thymus expression, immune and metabolic function, and regions of ancient synteny

Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Malignant Neoplasms of the Brain in Taiwan

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