Lipid abnormalities in chronic renal failure

Bhagwat, Rajesh; Joshi, S. P.; Salgia, Pradeep; Sepaha, Achal

doi:10.1007/bf02867962

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…In the present study we find high levels of LDL cholesterol in group 1 and 2 which were not statistically significant when compared to controls. Similar results are forwarded by Bhagwat et al (10). However, levels were significantly low in goup 3 when compared to controls.…”

Section: Discussionsupporting

confidence: 88%

“…There are western studies that showed hypercholesteremia (6) no hypercholesteremia (7) in CKD. However, there are only a few Indian studies (8,9,10) which have explored the atherogenic lipid profile at all the stages of CKD. The present study was undertaken to explore the altered lipid, lipoprotein and apoprotein abnormalities along with Lp(a) in CKD from stage I to stage V (ESRD) classified as per National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKFK/DOQI) guidelines (1) which plays a vital role in development of atherosclerotic cardiovascular disease.…”

Section: Introductionmentioning

confidence: 98%

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Lipid abnormalities, lipoprotein (a) and apoprotein pattern in non-dialyzed patients with chronic kidney disease

Rao

Bitla

Reddy

et al. 2010

Indian J Clin Biochem

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The present study was carried out to explore the altered lipid, lipoprotein and apoprotein abnormalities along with lipoprotein (a) in chronic kidney disease patients with stage I to V which were further divided into group 1 (stage I and II), group 2 (stage III and IV) and group 3 (stage V). 50 chronic kidney disease patients with stage I to V and 20 healthy normal subjects as controls were recruited for this study. Among the various parameters tested triglyceride levels were high in group 1 and 2, whereas VLDL cholesterol, Lp (a) and apo B levels were significantly high in all the groups when compared to controls (P<0.05). However, LDL cholesterol level was significantly low in group 3 only as compared to control group (P<0.05). Apoprotein AI values also showed significant decrease in all groups as compared to controls (P<0.05). Though total cholesterol levels in group 1 and LDL levels in group 1 and 2 were higher than controls, but the values attained not statistically significant (P>0.05). In conclusion high levels of VLDL cholesterol, Lp (a), apo B and low levels of apoprotein AI as reported in this study are the major lipid disorders in the development of cardiovascular complications at all the stages in these patients.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 98%

Lipid abnormalities, lipoprotein (a) and apoprotein pattern in non-dialyzed patients with chronic kidney disease

Rao

Bitla

Reddy

et al. 2010

Indian J Clin Biochem

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“…A study by Bhagwat et al, 1997 observed dyslipidemia to be independent of serum creatinine levels [20]. Values of LDL-C showed decreasing trends in CKD stage 4 and 5 [22].…”

Section: Summarizing the Observations In Various Stages Of Ckdmentioning

confidence: 99%

A study of lipid profile in chronic kidney disease in pre- dialysis patients

Choudhary

2019

Int J Med Res Rev

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Introduction:Longitudinal studies have established that Cardiovascular Disease (CVD) occur more frequently and are the leading cause of death in Chronic Kidney Disease (CKD). Dyslipidemia has been established as an important risk factor in the pathogenesis of CVD in CKD patients. Objectives: Present study was aimed to evaluate (in CKD patients), Demography along with Prevalence and Pattern of Dyslipidemiaand co-relation of Dyslipidemia with various CK Dstages. Methods: Present Cross-sectional study, conducted in Department of Medicine, R.D. Gardi Medical College and CRG hospital, Ujjain, M.P. from 1 st January 2015 to 31 st July 2016. We studied 115 pre-dialysis CKDcases and 100 age & sex matched controls. CKD was diagnosed as per 2012 KDOQI Criteria. Result: In CKD cases, maximum 23.47% cases belonged to fifth decade. Mean age was 48.99 ± 16.74. Male to Female ratio was1.21: 1. Prevalence of individual dyslipidemias was High TC= 50.44%, High TG= 67%, High LDL-C= 42%, High VLDL-C= 67% and Low HDL-C= 73.9%. Overall, prevalence of dyslipidemia was 82.6%. Significant increase in TG and VLDL-C and significant decrease in HDL-C was observed. TC and LDL-C were non-significantly increased.TC, TG, LDL-C and VLDL-C were in increasing trend with progression of CKD stages (3-5) and increased in Subgroup II (ESRD) as compared to Subgroup I (Non-ESRD), the increase being significant in case of TG and VLDL-C. HDL-C value was in decreasing trend with progression of CKD stages and significantly decreased in Subgroup II as compared to Subgroup I.TC, TG, LDL-C and VLDL-C showed negative correlation with GFR while HDL-C showed positive correlation. TG, HDL-C and VLDL-C showed highly significant correlation. HDL-C showed strongest correlation, followed by TG. Conclusion: Patients with CKD are predisposed to accelerated atherosclerosis leading to increased CVD. This study confirms the presence of atherogenic lipid profile in CKD.

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“…23,24 To reduce cardiovascular mortality due to dyslipidemia in CKD patients, early management with statins has been recommended by several studies. [25][26][27] Rhee et al recommended to follow guidelines and risk assessment before start of treatment of dyslipidemia. 28 Several studies have observed significant dyslipidemias as a major risk factor for CVD in non-diabetic CKD patients on hemodialysis and on conservative therapy.…”

Section: Introductionmentioning

confidence: 99%

Study of lipid profile in diabetic and non-diabetic chronic kidney disease patients on haemodialysis: a prospective comparative study from a sub Himalayan region in North India

Nand

Kumar

2020

Int J Adv Med

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Background: Diabetes mellitus (DM) is a major cause of chronic kidney disease (CKD) leading to diabetic kidney disease (DKD). Several studies have observed lipid profile abnormalities in non-diabetic CKD patients with and without haemodialysis. Our study aims to reveal lipid profile abnormalities both in DKD and non-diabetic CKD patients on haemodialysis.Methods: A prospective comparative study included 50 DKD and 50 non-diabetic CKD patients on haemodialysis and 50 controls after fulfilling the inclusion and exclusion criteria. The demographic and biochemical, including lipid profile parameters data of all subjects was collected and statistically analysed. p<0.05 was considered as statically significant.Results: A total of 100 study patients, 50 DKD and 50 non-diabetic CKD patients, both on haemodialysis revealed significant dyslipidaemia when compared to controls. Total cholesterol in DKD patients on haemodialysis when compared to controls (177.5±80.5 versus 146.5±31.8 mg/dl) was significantly elevated (p=0.01). Low density lipoprotein (LDL) in DKD patients when compared to controls (94.1±43.3 versus 76.3±26.3 mg/dl) was also significantly elevated (p=0.01). Triglyceride levels in both DKD and non-diabetic CKD patients on haemodialysis in comparison to controls (213.8±182.1 and 169.2±132.3 versus 109.2±28.9 mg/dl respectively) were significantly elevated (p=0.0002 and p=0.003 respectively). Similarly, very low-density lipoprotein (VLDL) levels in both DKD and non-diabetic CKD patients were also significantly elevated when compared to controls (p=0.002 and p=0.003 respectively) whereas high density lipoprotein (HDL) was significantly reduced.Conclusion: Both DKD and non-diabetic CKD patients on haemodialysis revealed significant dyslipidaemia, a major cause of increased risk for cardiovascular diseases necessitating early treatment with statins.

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Lipid abnormalities in chronic renal failure

Cited by 8 publications

References 9 publications

Lipid abnormalities, lipoprotein (a) and apoprotein pattern in non-dialyzed patients with chronic kidney disease

Lipid abnormalities, lipoprotein (a) and apoprotein pattern in non-dialyzed patients with chronic kidney disease

A study of lipid profile in chronic kidney disease in pre- dialysis patients

Study of lipid profile in diabetic and non-diabetic chronic kidney disease patients on haemodialysis: a prospective comparative study from a sub Himalayan region in North India

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