Lipid and fatty acid profiles of Pseudomonas aurantiaca DNA-bound lipids determined by mass spectrometry

Жданов, Р. И.; Kern, Daniel; Lorenz, W.; Ibragimova, M. Y.

doi:10.1134/s0026261714060228

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…Spectroscopic results indicate that oleic acid molecule shows molecular recognition of AT motifs by minor groove binding. In silico modeling suggests that PL species binding to the minor groove is energetically favorable, with input from hydrogen, van der Waals, and hydrophobic bonds [56][57][58]. Since there is a lipid fraction in the nucleus, apparently tightly bound to DNA, the possibility of a new informational level in genomic DNA ("lipid code") was postulated: lipids might specifically bind to the DNA in a sequence-specific way, and have significant functional roles for genome regulation.…”

Section: Lipid Species In Direct Association With Dna and Chromatinmentioning

confidence: 99%

Lipids contribute to epigenetic control via chromatin structure and functions

Жданов

Schirmer

Venkatasubramani

et al. 2015

ScienceOpen Research

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Isolated cases of experimental evidence over the last few decades have shown that, where specifically tested, both prokaryotes and eukaryotes have specific lipid species bound to nucleoproteins of the genome. In vitro, some of these lipid species exhibit stoichiometric association with DNA polynucleotides with differential affinities toward certain secondary and tertiary structures. Hydrophobic interactions with inner nuclear membrane could provide attractive anchor points for lipid-modified nucleoproteins in organizing the dynamic genome and accordingly there are precedents for covalent bonds between lipids and core histones and, under certain conditions, even DNA. Advances in biophysics, functional genomics, and proteomics in recent years brought about the first sparks of light that promises to uncover some coherent new level of the epigenetic code governed by certain types of lipid-lipid, DNA-lipid, and DNA-protein-lipid interactions among other biochemical lipid transactions in the nucleus. Here, we review some of the older and more recent findings and speculate on how critical nuclear lipid transactions are for individual cells, tissues, and organisms. SOR-LIFE

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Section: Lipid Species In Direct Association With Dna and Chromatinmentioning

confidence: 99%