Lipid-Based Nanocarrier System for the Effective Delivery of Nutraceuticals

Abstract

Nutraceuticals possess several health benefits and functions; however, most nutraceuticals are prone to degradation in the gastrointestinal environment and have poor bioavailability. Application of a novel carrier system is of increasing importance to overcome obstacles and provide efficient applicability. Lipid-based nanocarriers provide a large surface-to-mass ratio, enhanced intestinal absorption by solubilization in the intestinal milieu, intestinal lymphatic transport, and altering enterocyte-based transport. A critical overview of the current limitation, preparation, and application of lipid-based nanocarriers (liposomes and niosomes) and lipid nanoparticles (SLNs and NLCs) is discussed. Physical and gastrointestinal stability and bioavailability of nanoencapsulated nutraceuticals are considered as well.

Lysophosphatidylcholine‐based liposome to improve oral absorption and nephroprotective effects of astaxanthin

“…Among the various pharmaceutical techniques used to date, liposomes are utilized as promising delivery systems for bioactive substances and to overcome the problems related to their physicochemical properties 10,11 . Liposomes are made up of a phospholipid bilayer similar to the cell membrane structure around an aqueous core, which can encapsulate both lipophilic and hydrophilic compounds and protect them from adverse conditions 12 . In addition, liposomes can promote membrane permeability by enhancing the solubility of poorly water‐soluble compounds by entrapping them in a bilayer membrane and diffusing active molecules into the cell membrane, thereby increasing their oral bioavailability 13 .…”

“…10,11 Liposomes are made up of a phospholipid bilayer similar to the cell membrane structure around an aqueous core, which can encapsulate both lipophilic and hydrophilic compounds and protect them from adverse conditions. 12 In addition, liposomes can promote membrane permeability by enhancing the solubility of poorly water-soluble compounds by entrapping them in a bilayer membrane and diffusing active molecules into the cell membrane, thereby increasing their oral bioavailability. 13 They also exhibit biocompatibility, biodegradability, low-toxicity, and controlled-release properties.…”

Recent Progress of Lipid Nanoparticles-Based Lipophilic Drug Delivery: Focus on Surface Modifications

“…LNP forms are determined in various ways depending on the material used and the manufacturing method. Traditionally, various LNPs have been synthesized by emulsifying aqueous and organic phases in the presence of a surfactant through machine-based methods (such as a high-pressure homogenizer and ultra-sonication) or solvent-based methods (solvent extraction and evaporation) ( Figure 2 A–D) [ 37 , 38 , 39 , 40 , 41 ]. There are many perspectives to classify LNPs; however, this review described LNPs based on their core types.…”

Production of Bovine Colostrum for Human Consumption to Improve Health

“…One of the liposomal technology applications is to prepare functional additives as food products for various therapeutic applications. Liposomal technology has been used to preserve bovine colostrum and increase its bioavailability for human health ( Superti, 2020 ; Subramanian, 2021 ). The delivery of colostrum through the body with the reconstituted membrane phospholipids is far more effective in comparison to the colostrum without liposomal encapsulation.…”