Lipid based nanocarriers: a translational perspective

Mishra, Dinesh Kumar; Shandilya, Ruchita; Mishra, Pradyumna Kumar

doi:10.1016/j.nano.2018.05.021

Cited by 186 publications

(99 citation statements)

References 172 publications

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“…Nanocarriers can be widely classified as organic-based, inorganic-based, or a combination of both (Table 1) [5]. Organic nanocarriers are comprised of polymeric nanoparticles and lipid-based nanoparticles such as liposomes, nanoemulsions (e.g., micelles and reversed micelles), dendrimers, and carbon-based nanocarriers (e.g., fullerenes and carbon nanotubes).…”

Section: Classification Of Nanocarriersmentioning

confidence: 99%

An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety

Park

Kwon³

et al. 2018

Journal of Chemistry

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As the researches to utilize nanotechnology in food science are advanced, applications of nanotechnology in various fields of the food industry have increased. Nanotechnology can be applied to the food industry for production, processing, storage, and quality control of foods. Nanomaterials, unlike conventional microscale materials, having novel characteristics can improve sensory quality of foods by imparting novel texture, color, and appearance. Nanotechnology has been used to design nanosensors for detection of harmful components in foods and a smart packaging system enabling to recognize food contamination very rapidly and sensitively. Nanoencapsulation is the most significant technology in food science, especially for bioactive compounds and flavors. Targeted delivery systems designed with nanoencapsulation can enhance bioavailability of bioactive compounds after oral administration. In addition, nanoencapsulation enables to control the release of flavors at the desired time and to protect the degradation of flavors during processing and storage. In this review, current applications of nanotechnology in food science including flavor control, enhancement of bioavailability of bioactive compounds, and detection of deleterious substances in foods are presented. Furthermore, this article overviews classification, preparative methods, and safety issues of nanomaterials for food science. This review will be of help to provide comprehensive information for newcomers utilizing nanotechnology to the food sector.

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Section: Classification Of Nanocarriersmentioning

confidence: 99%

An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety

Park

Kwon³

et al. 2018

Journal of Chemistry

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Section: Alterations In the Vesicular Transport Of Cellsmentioning

confidence: 99%

“…Drug delivery strategies are those aimed to improve the bioavailability of drugs by modulating their solubility, stability, circulation, targeting and biodistribution, subcellular transport, and/or release rate [169,170,171,172,173,174]. Therefore, these approaches help enhance the therapeutic value of drugs and minimize their toxicity [169,170,171,172,173,174]. A variety of formulations have been designed for this purpose, from conjugates to nanoparticle carriers, including linear, branched and dendrimeric polymers, micelles, liposomes and polymersomes, several types of porous and solid particles, and modified versions of natural vesicles [172,173,174,175,176,177,178].…”

Section: Alterations In the Vesicular Transport Of Cellsmentioning

confidence: 99%

“…Therefore, these approaches help enhance the therapeutic value of drugs and minimize their toxicity [169,170,171,172,173,174]. A variety of formulations have been designed for this purpose, from conjugates to nanoparticle carriers, including linear, branched and dendrimeric polymers, micelles, liposomes and polymersomes, several types of porous and solid particles, and modified versions of natural vesicles [172,173,174,175,176,177,178]. These carriers can be fabricated out of natural and/or synthetic materials, organic and/or inorganic ones, and may be biodegradable at different extents and through different mechanisms [172,173,174,175,176,177,178].…”

Section: Alterations In the Vesicular Transport Of Cellsmentioning

confidence: 99%

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Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery

Muro

2018

Biomimetics

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Endocytosis and vesicular trafficking are cellular processes that regulate numerous functions required to sustain life. From a translational perspective, they offer avenues to improve the access of therapeutic drugs across cellular barriers that separate body compartments and into diseased cells. However, the fact that many factors have the potential to alter these routes, impacting our ability to effectively exploit them, is often overlooked. Altered vesicular transport may arise from the molecular defects underlying the pathological syndrome which we aim to treat, the activity of the drugs being used, or side effects derived from the drug carriers employed. In addition, most cellular models currently available do not properly reflect key physiological parameters of the biological environment in the body, hindering translational progress. This article offers a critical overview of these topics, discussing current achievements, limitations and future perspectives on the use of vesicular transport for drug delivery applications.

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“…In later years, Professor Norio Taniguichi, a MIT-based American engineer, drew significant attention from a wider audience to the nanotechnological field. During the 1990s, many nanotechnological applications were derived from a specialized form of materials science [8]. However, these materials are currently used for a number of applications in various fields such as energy, electronics, food and agriculture, cosmetics, and healthcare.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology in reproductive medicine: Opportunities for clinical translation

Shandilya

Pathak

Lohiya

et al. 2020

Clin Exp Reprod Med

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In recent years, nanotechnology has revolutionized global healthcare and has been predicted to exert a remarkable effect on clinical medicine. In this context, the clinical use of nanomaterials for cancer diagnosis, fertility preservation, and the management of infertility and other pathologies linked to pubertal development, menopause, sexually transmitted infections, and HIV (human immunodeficiency virus) has substantial promise to fill the existing lacunae in reproductive healthcare. Of late, a number of clinical trials involving the use of nanoparticles for the early detection of reproductive tract infections and cancers, targeted drug delivery, and cellular therapeutics have been conducted. However, most of these trials of nanoengineering are still at a nascent stage, and better synergy between pharmaceutics, chemistry, and cutting-edge molecular sciences is needed for effective translation of these interventions from bench to bedside. To bridge the gap between translational outcome and product development, strategic partnerships with the insight and ability to anticipate challenges, as well as an in-depth understanding of the molecular pathways involved, are highly essential. Such amalgamations would overcome the regulatory gauntlet and technical hurdles, thereby facilitating the effective clinical translation of these nano-based tools and technologies. The present review comprehensively focuses on emerging applications of nanotechnology, which holds enormous promise for improved therapeutics and early diagnosis of various human reproductive tract diseases and conditions.

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Lipid based nanocarriers: a translational perspective

Cited by 186 publications

References 172 publications

An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety

An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety

Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery

Nanotechnology in reproductive medicine: Opportunities for clinical translation

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