Lipid Deposition Profiles Influence Foreign Body Responses (Adv. Mater. 21/2023)

Schreib, Christian C.; Jarvis, Maria; Terlier, Tanguy; Goell, Jacob; Mukherjee, Sudip; Doerfert, Michael D.; Wilson, Taylor; Beauregard, Michael; Martins, Kevin N.; Lee, John; Solis, Leonardo D. Sanchez; Vázquez, Esperanza; Oberli, Matthias A.; Hanak, Brian W.; Diehl, Michael R.; Hilton, Isaac B.; Veiseh, Omid

doi:10.1002/adma.202370150

Cited by 2 publications

(5 citation statements)

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“…PA has been reported to protect lipopolysaccharide (LPS)-induced septic mice by pharmacologic inhibition. [29e] The greater number of phospholipid species is in general agreement with the SIMS study of Schreib et al [9] where lower FBR implants correlated with phospholipids after 24 h of implantation.…”

Section: Characterisation Of Metabolite Changes In Tissue Local To Im...supporting

confidence: 82%

“…[28] A recent study by Schreib et al, reported that lipids were deposited by host cells on the surface of a biomaterial after implantation and that the types of lipids correlate with how the immune system reacts to the biomaterial. [9] The anti-inflammatory implants demonstrated significant enrichment of phospholipids hypothesized to be antifibrotic at the explanted implant surface. Our observation of glycerolipids in the tissue above the anti-fibrotic M1-inducing samples in our study suggests that these two observations may be linked.…”

Section: Characterisation Of Metabolite Changes In Tissue Local To Im...mentioning

confidence: 97%

“…Moreover, in mouse macrophages, phospholipid deposition upregulates anti-inflammatory genes whereas fatty acid deposition upregulates pro-inflammatory genes. [9] These findings offer more understanding of how different surface chemistries could modulate macrophage phenotype.…”

Section: Introductionmentioning

confidence: 94%

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Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids

Suvannapruk,

Fisher,

Luckett

et al. 2024

Advanced Science

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A key goal for implanted medical devices is that they do not elicit a detrimental immune response. Macrophages play critical roles in the modulation of the host immune response and are the cells responsible for persistent inflammatory reactions to implanted biomaterials. Two novel immune‐instructive polymers that stimulate pro‐ or anti‐inflammatory responses from macrophages in vitro are investigated. These also modulate in vivo foreign body responses (FBR) when implanted subcutaneously in mice. Immunofluorescent staining of tissue abutting the polymer reveals responses consistent with pro‐ or anti‐inflammatory responses previously described for these polymers. Three Dimensional OrbiTrap Secondary Ion Mass Spectrometry (3D OrbiSIMS) analysis to spatially characterize the metabolites in the tissue surrounding the implant, providing molecular histology insight into the metabolite response in the host is applied. For the pro‐inflammatory polymer, monoacylglycerols (MG) and diacylglycerols (DG) are observed at increased intensity, while for the anti‐inflammatory coating, the number of phospholipid species detected decreased, and pyridine and pyrimidine levels are elevated. Small molecule signatures from single‐cell studies of M2 macrophages in vitro correlate with the in vivo observations, suggesting potential for prediction. Metabolite characterization by the 3D OrbiSIMS is shown to provide insight into the mechanism of bio‐instructive materials as medical devices and to inform on the FBR to biomaterials.

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Section: Characterisation Of Metabolite Changes In Tissue Local To Im...supporting

confidence: 82%

Section: Characterisation Of Metabolite Changes In Tissue Local To Im...mentioning

confidence: 97%

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Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids

Suvannapruk,

Fisher,

Luckett

et al. 2024

Advanced Science

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“…[139,140] A recent study has shed light on the intimate relationship between lipid deposition and the exceptional anti-FBR properties of the aforementioned structural modifications (Z2-Y12 and Z1-Y15) (Figure 13). [141] This revelation was achieved by applying the time-of-flight secondary ion mass spectroscopy (ToF-SIMS) technique. Notably, an array of immunosuppressive phospholipids, encompassing phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, and sphingomyelin, have been observed to selectively accumulate on implants featuring surface alterations designed to resist FBR in murine models.…”

Section: Immunoactive Coatingsmentioning

confidence: 99%

mentioning

confidence: 99%

Materials Strategies to Overcome the Foreign Body Response

Zhou,

Wang,

et al. 2024

Adv Healthcare Materials

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The foreign body response (FBR) is an immune‐mediated reaction that can occur with most biomaterials and biomedical devices. The FBR initiates a deterioration in the performance of implantable devices, representing a longstanding challenge that has consistently hampered their optimal utilization. Over the last decade, significant strides have been achieved based on either hydrogel design or surface modifications to mitigate the FBR. This review delves into recent material strategies aimed at mitigating the FBR. Furthermore, we look forward to future novel anti‐FBR materials from the perspective of clinical translation needs. Such prospective materials hold the potential to attenuate local immune responses, thereby significantly enhancing the overall performance of implantable devices.This article is protected by copyright. All rights reserved

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Lipid Deposition Profiles Influence Foreign Body Responses (Adv. Mater. 21/2023)

Cited by 2 publications

References 0 publications

Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids

Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids

Materials Strategies to Overcome the Foreign Body Response

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