Lipid Droplet Surface Promotes 3D Morphological Evolution of Non‐Rhomboidal Cholesterol Crystals
Hyun‐Ro Lee,
Seunghan Kang,
Siyoung Q. Choi
Abstract:Cholesterol crystals, which cause inflammation and various diseases, predominantly grow in a platy, rhomboid structure on the plasma membranes but exhibit an uneven three‐dimensional (3D) architecture intracellularly. Here, it is demonstrated how cholesterol crystallizes in a non‐rhomboidal shape on the surface of lipid droplets and develops into 3D sheet‐like agglomerates using an in vitro lipid droplet reconstitution system with stereoscopic fluorescence imaging. The findings reveal that interfacial choleste… Show more
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