The aim of the present study was to determine the environmental characteristics and water quality of a drainage basin impacted by human activities in order to obtain quantitative information for helping the development of environmental management politics of soils, lakes, rivers and water resources. Physicochemical properties and concentrations of metals were determined in different water samples. Dissolved oxygen, pH, turbidity, color, ammonia, phosphorus, phenol, copper, silver, lead, cadmium and iron differed from levels considered acceptable by international regulations, indicating potential environmental pollution due to land occupation and the improper disposal of domestic, industrial and agricultural waste. The leaching of pollutants from the soil to bodies of water was also found. Total dissolved solids, salinity, suspended solids, nitrate, nitrite and zinc levels were lower than the limits imposed by international regulations, but have been increasing over time. Urbanization, industrialization and agricultural processes in drainage basins significantly affect the natural characteristics of the environment, leading to an increase in the concentrations of pollutants and a reduction in the quality of water, plants and soils. As pollutants in drainage basins generally enter into soils, rivers, lakes and ocean, it is necessary to obtain quantitative information about the human impacts in the water quality for developing environmental management politics aiming to preserve the water resources.