Lipid-lnduced Glomerular Injury

Guijarro, Carlos; Keane, William F.

doi:10.1159/000187881

Cited by 38 publications

(17 citation statements)

References 56 publications

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“…Abnormalities in lipid metabolism frequently accompany renal disease and may be important in the pathogenesis of progressive renal injury. The glomerulus and the renal interstitium may be preferred locations for lipid depositions in the kidney because of the presence of fenestrated endothelia in the glomerular capillaries [1,2]. Furthermore, the glomerular mesangial cells and matrix are not separated from the capillary stream by a basement membrane [3].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Vitamin E and Selenium on the Renal Morphology in Rats Fed High-Cholesterol Diets

Gonca¹,

Ceylan²,

Yardımoğlu³

et al. 2000

Pathobiology

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The histopathological effects of cholesterol and the protective effects of vitamin E and selenium (Se) on renal histology were examined in Sprague-Dawley rats. Light-microscopic evaluation of the renal cortex revealed: glomerular fibrosis, cellular and mesangial proliferation, capillary obliteration and cholesterol crystals in the tubular lumina of the cholesterol-fed group. These results suggest that oxidated LDL (O-LDL) is a cytotoxic factor which stimulates mesangial cell and matrix proliferation. Ultrastructurally, small and large lipid vacuolization in intracapillary lumina, adhesion of epithelial foot processes, mesangial foam cells and polymorphonuclear leukocytes were seen in the cholesterol-fed group. In the groups fed cholesterol + vitamin E, cholesterol + Se and cholesterol + vitamin E + Se, morphological improvements were observed. It appeared that an excess in O-LDL, reactive oxygen species and growth factors might play an important role in the pathogenesis of glomerulosclerosis. In addition, it was concluded that antioxidant therapy may prevent LDL oxidation and generation of free radicals.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Vitamin E and Selenium on the Renal Morphology in Rats Fed High-Cholesterol Diets

Gonca¹,

Ceylan²,

Yardımoğlu³

et al. 2000

Pathobiology

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show abstract

“…Alterations in circulating lipids have also been linked to development or progression of FSGS. Elevated serum cholesterol increases TGF-β and increases glomerulosclerosis in experimental nephrotic syndrome [38, 39, 40]. Lipoprotein uptake by mesangial cells is increased by vasoconstrictors, angiotensin II, endothelin or thromboxane [41, 42], and native and oxidized low-density lipoprotein uptake by mesangial cells and endothelial cells induces production of cytokines and growth factors and extracellular matrix (ECM) components [43, 44, 45].…”

Section: Initiators and Promoters Of Fsgsmentioning

confidence: 99%

Molecular Basis of Injury and Progression in Focal Glomerulosclerosis

Harris¹

1999

Nephron

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“…We know that hyperlipidaemia promotes mesangial cell damage and permeability of the glomerular capillary walls, and ultimately there will be glomerulosclerosis [22]. Hence antilipaemic measures are important for preventing progression of renal diseases [23]. Soyprotein diets do reduce blood pressure and ameliorate proteinuria.…”

Section: Soyprotein Diet For Nephrotic Syndromementioning

confidence: 99%

Soyprotein Diet Therapy in Renal Disease

Wardle¹

1998

Nephron

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Lipid-lnduced Glomerular Injury

Cited by 38 publications

References 56 publications

Protective Effects of Vitamin E and Selenium on the Renal Morphology in Rats Fed High-Cholesterol Diets

Protective Effects of Vitamin E and Selenium on the Renal Morphology in Rats Fed High-Cholesterol Diets

Molecular Basis of Injury and Progression in Focal Glomerulosclerosis

Soyprotein Diet Therapy in Renal Disease

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