Lipid nanocarriers

Shukla, Tripti; Upmanyu, Neeraj; Pandey, Sharad Prakash; Gosh, Dipanjana

doi:10.1016/b978-0-12-813687-4.00001-3

Cited by 23 publications

(22 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EAs induced flexibility prevents the chances of vesicular rupture. 8 The flexibility of transferosomes enables them to penetrate the stratum corneum via intercellular lipid spaces. Kong et al explored transdermal route for transfersome mediated delivery to treat tumor metastasis.…”

Section: Lipid-based Nanocarrier Systems and The Effect Of Surface Mo...mentioning

confidence: 99%

Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

2022

View full text Add to dashboard Cite

Nanocarriers have the utmost significance for advancements in drug delivery and nanomedicine technology. They are classified as polymer-based nanocarriers, lipid-based nanocarriers, viral nanoparticles, or inorganic nanoparticles, depending on their constituent parts. Lipid-based nanocarrier systems have gained tremendous attention over the years because of their noteworthy properties like high drug-loading capacity, lower toxicity, better bioavailability and biocompatibility, stability in the gastrointestinal tract, controlled release, simpler scale-up, and validation process. Nanocarriers still have some disadvantages like poor drug penetration, limited drug encapsulation, and poor targeting. These disadvantages can be overcome by their surface modification. Surface-modified nanocarriers result in controlled release, enhanced penetration efficiency, and targeted medication delivery. In this review, the authors summarize the numerous lipidbased nanocarriers and their functionalization through various surface modifiers such as polymers, ligands, surfactants, and fatty acids. Recent examples of newly developing surface-modified lipid-based nanocarrier systems from the available literature, along with their applications, have been compiled in this work.

show abstract

Section: Lipid-based Nanocarrier Systems and The Effect Of Surface Mo...mentioning

confidence: 99%

Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

2022

View full text Add to dashboard Cite

show abstract

“…Many formulations based on lipidic structures have been prepared, i.e., liposomes and similar carriers such as ethosomes, transfersomes, solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates, etc. [ 33 ]. Usually, these carriers demonstrate lower toxicity profiles and more reasonable cost compared to polymeric carriers [ 34 ].…”

Section: Organic-based Delivery Systemsmentioning

confidence: 99%

“…The oldest vesicular system, first developed in the 1960s, is liposomes (from the Greek words “lipos” (fat) and “soma” (body)) [ 33 ]. Liposomes are highly efficient and relatively easy to produce, have a size that ranges from a few nanometers to several micrometers and demonstrate specific advantages for the encapsulation and targeted delivery of both hydrophilic and lipophilic molecules.…”

Section: Organic-based Delivery Systemsmentioning

confidence: 99%

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Kyriakoudi

Spanidi²,

Mourtzinos

et al. 2021

Plants

View full text Add to dashboard Cite

Plants constitute a rich source of diverse classes of valuable phytochemicals (e.g., phenolic acids, flavonoids, carotenoids, alkaloids) with proven biological activity (e.g., antioxidant, anti-inflammatory, antimicrobial, etc.). However, factors such as low stability, poor solubility and bioavailability limit their food, cosmetics and pharmaceutical applications. In this regard, a wide range of delivery systems have been developed to increase the stability of plant-derived bioactive compounds upon processing, storage or under gastrointestinal digestion conditions, to enhance their solubility, to mask undesirable flavors as well as to efficiently deliver them to the target tissues where they can exert their biological activity and promote human health. In the present review, the latest advances regarding the design of innovative delivery systems for pure plant bioactive compounds, extracts or essential oils, in order to overcome the above-mentioned challenges, are presented. Moreover, a broad spectrum of applications along with future trends are critically discussed.

show abstract

“…Lipid-based NPs such as liposomes, NLCs, SLNs are considered vital nanocarrier systems for brain targeting (Mansor et al 2019;Niu et al 2019). Moreover, to overcome the glitches associated with polymer NPs, lipid-based nanocarriers have gained more attention for effective targeting (Shukla et al 2018;Harshita et al 2020). However, despite the advantages of using nanocarriers in various diseases, including GBM, they can still potentiate various toxicities induced by oxidative stress, inflammation, and DNA damage Fig.…”

Section: Lipid-based Nanocarriers: Flexible Platform For Targeted Drug Delivery To the Brainmentioning

confidence: 99%

“…Liposomes are considered first-generation lipid-based NPs, which were one of the first-ever drug delivery carriers used to transport anticancer and antimicrobial drugs into cells (Yingchoncharoen et al 2016;Shukla et al 2018).…”

Section: Liposomesmentioning

confidence: 99%

Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches

Hegde

Prabhu²,

Mutalik

et al. 2021

J. Pharm. Investig.

View full text Add to dashboard Cite

Background Glioblastoma, or glioblastoma multiforme (GBM), remains a fatal cancer type despite the remarkable progress in understanding the genesis and propagation of the tumor. Current treatment modalities, comprising mainly of surgery followed by adjuvant chemoradiation, are insufficient for improving patients' survival owing to existing hurdles, including the blood–brain barrier (BBB). In contemporary practice, the prospect of long-term survival or cure continues to be a challenge for patients suffering from GBM. This review provides an insight into the drug delivery strategies and the significant efforts made in lipid-based nanoplatform research to circumvent the challenges in optimal drug delivery in GBM. Area covered Owing to the unique properties of lipid-based nanoplatforms and advancements in clinical translation, this article describes the application of various stimuli-responsive lipid nanocarriers and tumor subcellular organelle-targeted therapy to give an idea about the strategies that can be applied to enhance site-specific drug delivery for GBM. Furthermore, active targeting of drugs via surface-modified lipid-based nanostructures and recent findings in alternative therapeutic platforms such as gene therapy, immunotherapy, and multimodal therapy have also been overviewed. Expert opinion Lipid-based nanoparticles stand out among the other nanocarriers explored for GBM drug delivery, as they support both passive and active drug targeting by crossing/bypassing the BBB at the same time minimizing toxicity and projects better pharmacological parameters. Although these nanocarriers could be a plausible choice for treating GBM, in-depth research is essential to advance neuro-oncology research and enhance outcomes in patients with brain tumors.

show abstract

Lipid nanocarriers

Cited by 23 publications

References 101 publications

Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches

Contact Info

Product

Resources

About