Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)

Fang, Jia You; Fang, Chia Lang; Liu, Chi Hsien; Su, Yu Han

doi:10.1016/j.ejpb.2008.05.008

Cited by 450 publications

(197 citation statements)

References 33 publications

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“…The sizes of SLNs were reported as being considerably larger than those of NLCs (297 nm compared to 210 nm) when prepared with the same procedure, surfactant types and concentrations, and total lipid amount. 31 Gokce et al reported that NLCs in all tested oil/lipid ratios (5%, 15%, 30%, and 45%) were smaller than SLNs under identical conditions (the same total lipid concentrations and preparation parameters). The comparison of polydispersity indices for various formulations reported in this study revealed that an increase in the oil/lipid ratio resulted in a decrease in size distribution.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

180

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Section: Introductionmentioning

confidence: 99%

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

180

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“…For this reason, the higher loading capacity could be achieved through the development of NLCs. 16,24 It is worth noting that the pH of 10.3 was selected based on the literature investigating the topical and sublingual absorption of SC. Lia and Chang 2 have reported that the transport amount of SC had the highest permeation rate in nude mouse skin, at pH 8-11.…”

Section: Ph Of the Nanoparticle External Phasementioning

confidence: 99%

“…NLCs have been shown to possess improved drug loading, adjusted drug release, and minimum drug expulsion during storage. 16 NLCs remain in their solid state through controlling the liquid lipid content added to the formulation; therefore, controlled drug release properties can be achieved with NLCs. 17 NLCs have also proved effective in the field of transdermal drug permeation.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles

Elnaggar¹,

El-Massik²,

Abdallah³

2011

IJN

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Although sildenafil citrate (SC) is used extensively for erectile dysfunction, oral delivery of SC encounters many obstacles. Furthermore, the physicochemical characteristics of this amphoteric drug are challenging for delivery system formulation and transdermal permeation. This article concerns the assessment of the potential of nanomedicine for improving SC delivery and transdermal permeation. SC-loaded nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) were fabricated using a modified high-shear homogenization technique. Nanoparticle optimization steps included particle size analysis, entrapment efficiency (EE) determination, freeze-drying and reconstitution, differential scanning calorimetry, in vitro release, stability study and high-performance liquid chromatography analysis. Transdermal permeation of the nanocarriers compared with SC suspension across human skin was assessed using a modified Franz diffusion cell assembly. Results revealed that SLNs and NLCs could be optimized in the nanometric range (180 and 100 nm, respectively) with excellent EE (96.7% and 97.5%, respectively). Nanoparticles have significantly enhanced in vitro release and transdermal permeation of SC compared with its suspensions. Furthermore, transdermal permeation of SC exhibited higher initial release from both SLN and NLC formulations followed by controlled release, with promising implications for faster onset and longer drug duration. Nanomedicines prepared exhibited excellent physical stability for the study period. Solid nanoparticles optimized in this study successfully improved SC characteristics, paving the way for an efficient topical Viagra ® product.

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“…NLC has attracted increasing scientific and commercial attention during the last few years (1,2) due to the lower risk of systemic side effects and is suitable for transdermal administration (3,4). It has benefi ts over SLN in improving release properties (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Effect of surfactant on lycopene-loaded nanostructured lipid carriers

Riangjanapatee

Okonogi

2012

Drug Discov Ther

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Nanostructured lipid carriers (NLC) have gained high interest as enhancing drug delivery systems via topical application during the last few years. NLC can enhance stability of many active substances against environmental stress. The extremely small size of NLC plays an important role in skin penetration. The unchanged size of NLC upon storage indicates its physical stability. The aim of this work was to investigate the effect of surfactant type on physical properties and stability of lycopene-loaded NLC. The preparation of the NLC was achieved by means of high pressure homogenization. The results indicate that different types of surfactant yield NLC with different properties. We also explored the effect of contact angle on the size of the NLC. It was found that the small contact angle gave NLC with small size. Among two small contact angle surfactants, Plantacare 1200 gave lycopene-loaded NLC with smaller size, higher zeta potential and narrower size distribution. The particle size, size distribution, and zeta potential of lycopene-loaded NLC prepared with Plantacare 1200 was unchanged during 30 days of storage. It was concluded that Plantacare 1200 is the most suitable surfactant for lycopene-loaded NLC. The chemical stability of lycopene entrapped in the NLC was significantly enhanced.

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Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)

Cited by 450 publications

References 33 publications

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles

Effect of surfactant on lycopene-loaded nanostructured lipid carriers

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