Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol

Abstract

Orobol is one of the major soy isoflavones, and has been reported to have various pharmacological activities, including an anti-skin-aging effect. However, since it has low solubility in water and physicochemical instability, the formulation of orobol for delivery into the dermal layer of the skin could be challenging. The objective of this study was to prepare lipid nanoparticles formulations of orobol to enhance its stability as well as its deposition into the skin. Formulations of orobol-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were characterized in terms of their mean particle size, entrapment efficiency, and morphology. The nano-sized spherical NLCs formulations maintained the stability of orobol for up to 28 days. Moreover, the NLCs formulation significantly increased the in vitro deposition of orobol into both Strat-M membranes and human cadaver skin compared with the other formulations. Additionally, the NLCs formulation did not cause significant skin irritation in clinical study. These results demonstrate that a shea butter-based NLC formulation could be a promising and safe carrier system for improving the stability of orobol and enhancing its topical skin delivery.

Orobol from enzyme biotransformation attenuatesDermatophagoides farinae-induced atopic dermatitis-like symptoms in NC/Nga mice

“…For these reasons, many researchers are searching for new phytochemicals with use as topical formulations to increase their stability and delivery efficiency. [30][31][32][33][34] In this study, for the first time, we found a metabolite of genistein, orobol, which has anti-atopic effects in animals and cell models.…”

Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges

“…Polymeric micelles Curcumin Whitening [183] Nanostructured lipid carriers Passiflora edulis seeds oil Whitening [184] Niosomes Quercetin Whitening [109] Niosomes Arbutin Whitening [110] Nano sponges Azelaic acid Whitening [145] Nanostructured lipid carriers Orobol Anti-ageing [185] Nanoliposomes Carnosine Palmitoyl tripeptide-5 Acetyl hexapeptide-3 Anti-ageing [186] Table 3. Cont.…”

The Antibiofilm Nanosystems for Improved Infection Inhibition of Microbes in Skin

“…These lipids including soybean oil, coconut oil, sesame oil, linseed oil, and grape seed oil are already verified to be biodegradable and biocompatible. The topically applied NLCs are reported to be safe to cause no skin irritation in human [170]. The lipid nanoparticles made with linseed oil is safe for skin application because the nanoparticles were not irritant, sensitizing, and comedogenic on skin [171].…”