Lipid nanoparticles in topical dermal drug delivery: Does chemistry of lipid persuade skin penetration?

Jyothi, Vaskuri G.S. Sainaga; Ghouse, Shaik Mahammad; Khatri, Dharmendra Kumar; Nanduri, Srinivas; Singh, Shashi Bala; Madan, Jitender

doi:10.1016/j.jddst.2022.103176

Cited by 19 publications

(10 citation statements)

References 109 publications

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“…Quantum dots exhibit potential in reproductive medicine by enabling precise delivery of therapeutic molecules, optimizing efficacy while minimizing side effects . Liposomes and lipid nanoparticles find applications in encapsulating hormones and growth factors, improving stability and bioavailability for enhanced efficacy in reproductive medicine treatments Figure illustrates various nanoparticles and their potential advantages in treating reproductive problems.…”

Section: Characteristic Features Of Nanoparticles As a Drug Carriermentioning

confidence: 99%

“…30 Liposomes and lipid nanoparticles find applications in encapsulating hormones and growth factors, improving stability and bioavailability for enhanced efficacy in reproductive medicine treatments. 31 Figure 2 illustrates various nanoparticles and their potential advantages in treating reproductive problems. To choose appropriate nanoparticles for targeting reproductive disorders, factors such as size, surface charge, biocompatibility, and specific targeting abilities must be carefully considered.…”

Section: Characteristic Features Of Nanoparticles As a Drug Carriermentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

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Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important in reproductive health care, which has become an emerging and significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, and reproductive cancers. Nanotechnology presents promising solutions to address these concerns by introducing innovative tools and techniques, facilitating early detection, targeted drug delivery, and improved imaging capabilities. Through the utilization of nanoscale materials and devices, researchers can craft treatments that are not only more precise but also more effective, significantly enhancing outcomes in reproductive healthcare. Looking forward, the future of nanotechnology in reproductive medicine holds immense potential for reshaping diagnostics, personalized therapies, and fertility preservation. The utilization of nanotechnology-driven drug delivery systems is anticipated to elevate treatment effectiveness, minimize side effects, and offer patients therapies that are not only more precise but also more efficient. This review aims to delve into the various types, properties, and preparation techniques of nanocarriers specifically designed for drug delivery in the context of reproductive disorders, shedding light on the current landscape and potential future directions in this dynamic field.

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Section: Characteristic Features Of Nanoparticles As a Drug Carriermentioning

confidence: 99%

Section: Characteristic Features Of Nanoparticles As a Drug Carriermentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…The addition of surfactants allows for the electrosteric stabilization of NLCs, where the increase in surfactant concentration usually shifts the zeta potential of NLCs to higher values [7]. The surface charge is vital in transdermal drug delivery as the charge affects the permeation of nanocarriers across the skin layers [41].…”

Section: Particle Size Distribution Polydispersity Index and Zeta Pot...mentioning

confidence: 99%

Nanostructured Lipid Carriers for Transdermal Drug Delivery

et al. 2022

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Transdermal drug delivery offers many advantages over oral delivery, such as avoiding first-pass metabolism, enhancing the bioavailability of poorly soluble drugs, and providing better patient compliance. However, only small lipophilic molecules can be delivered across the stratum corneum, the outermost layer of the skin. Unfortunately, the delivery of larger molecules remains a challenge. Nanostructured lipid carriers (NLCs) are second-generation lipid nanocarriers composed of biocompatible solid lipids, liquid lipids, surfactants, and co-surfactants. NLCs can be loaded with various classes of drugs, provide a controlled drug release profile, enhance drug stability, and be scaled up without needing organic solvents. This review article discusses the features, composition, formulation processes, and characterization of NLCs and their potential use in transdermal drug delivery.

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“…Due to recent technological advances in the field of drug delivery (e.g., the fabrication of functionalised biopolymers) and the growing demand for more localised delivery to reduce side effects, the oral route of administration is becoming less popular [ 1 ]. Skin delivery offers an attractive alternative to oral drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

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Skin delivery is an exciting and challenging field. It is a promising approach for effective drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many other advantages. The main associated challenge, however, is low skin permeability. The skin is a healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in skin delivery (both topical and transdermal) depend on overcoming the challenges associated with drug molecule permeation and skin irritation. These limitations can be overcome by employing new approaches such as lipid nanosystems. Due to their advantages (such as easy scaling, low cost, and remarkable stability) these systems have attracted interest from the scientific community. However, for a successful formulation, several factors including particle size, surface charge, components, etc. have to be understood and controlled. This review provided a brief overview of the structure of the skin as well as the different pathways of nanoparticle penetration. In addition, the main factors influencing the penetration of nanoparticles have been highlighted. Applications of lipid nanosystems for dermal and transdermal delivery, as well as regulatory aspects, were critically discussed.

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Lipid nanoparticles in topical dermal drug delivery: Does chemistry of lipid persuade skin penetration?

Cited by 19 publications

References 109 publications

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Nanostructured Lipid Carriers for Transdermal Drug Delivery

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

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